mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2017-2-41-46mrj-753Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSNLRP12 -ассоциированный периодический синдром: описание собственного наблюдения и анализ данных литературыNLRP12-associated periodic syndrome: A description of the authors' own observation and an analysis of literature dataДубкоМ. Ф.DubkoM. F.kost-mikhail@yandex.ruСуспицынЕ. Н.SuspitsynE. N.kost-mikhail@yandex.ruСоколенкоА. П.SokolenkoA. P.kost-mikhail@yandex.ruИмянитовЕ. Н.ImyanitovE. N.kost-mikhail@yandex.ruЛихачеваТ. С.LikhachevaT. S.kost-mikhail@yandex.ruКазанцеваА. Ю.KazantsevaA. Yu.kost-mikhail@yandex.ruКалашниковаО. В.KalashnikovaO. V.kost-mikhail@yandex.ruЧасныкВ. Г.ChasnykV. G.kost-mikhail@yandex.ruКостикМ. М.KostikM. M.kost-mikhail@yandex.ruФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, Санкт-ПетербургРоссияSaint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint PetersburgRussian FederationФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, Санкт-Петербург ФГБУ «Научно-исследовательский институт онкологии им. Н.Н. Петрова» Минздрава России, Санкт-ПетербургРоссияSaint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia, Saint PetersburgRussian FederationФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, Санкт-Петербург ФГБУ «Научно-исследовательский институт онкологии им. Н.Н. Петрова» Минздрава России, Санкт-Петербург ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, Санкт-ПетербургРоссияSaint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia, Saint Petersburg I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgRussian Federation2017240420171124146Copyright © Дубко М.Ф., Суспицын Е.Н., Соколенко А.П., Имянитов Е.Н., Лихачева Т.С., Казанцева А.Ю., Калашникова О.В., Часнык В.Г., Костик М.М., 20172017Дубко М.Ф., Суспицын Е.Н., Соколенко А.П., Имянитов Е.Н., Лихачева Т.С., Казанцева А.Ю., Калашникова О.В., Часнык В.Г., Костик М.М.Dubko M.F., Suspitsyn E.N., Sokolenko A.P., Imyanitov E.N., Likhacheva T.S., Kazantseva A.Y., Kalashnikova O.V., Chasnyk V.G., Kostik M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/753

Аутовоспалительные заболевания (АВЗ) – это группа редких заболеваний, характеризующихся персистирующим или возвратным воспалением, обусловленным гиперактивацией медиаторов и клеток врожденного иммунитета (нейтрофилов, моноцитов/макрофагов). В статье приводятся описание собственного наблюдения NLRP12-ассоциированного АВЗ, эффективности терапии канакинумабом, а также обзор серии случаев аналогичного заболевания, представленных в литературе.

 

Autoinflammatory diseases (AIDs) are a group of rare disorders characterized by persistent or recurrent inflammation caused by the hyperactivation of mediators and innate immune cells (neutrophils, monocytes/macrophages). The paper describes the authors' own case of NLRP12-associated AIDs and the efficiency of canakinumab therapy and reviews a series of cases of the similar disease, which are given in the literature.

 

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The authors declare that there are no conflicts of interest present.