References

mrj

Современная ревматология

Modern Rheumatology Journal

1996-70122310-158X

IMA-PRESS, LLC

10.14412/1996-7012-2017-2-60-67

mrj-757

Research Article

ОБЗОРЫ

REVIEWS

Helicobacter pylori как триггерный и отягощающий фактор при ревматоидном артрите и других ревматических заболеваниях

Helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseases

Плахова

А. О.

Plakhova

A. O.

aekarat@yandex.ru

Никитина

Е. С.

Nikitina

E. S.

aekarat@yandex.ru

Сороцкая

В. Н.

Sorotskaya

V. N.

aekarat@yandex.ru

Каратеев

А. Е.

Karateev

A. E.

aekarat@yandex.ru

ФГБОУ ВО «Тульский государственный университет», ТулаРоссияTula State University, TulaRussian Federation

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», МоскваРоссияV.A. Nasonova Research Institute of Rheumatology, MoscowRussian Federation

2017

25042017

1126067

2017

Плахова А.О., Никитина Е.С., Сороцкая В.Н., Каратеев А.Е.

Plakhova A.O., Nikitina E.S., Sorotskaya V.N., Karateev A.E.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://mrj.ima-press.net/mrj/article/view/757

Helicobacter pylori – самая распространенная инфекция человека. H. pylori известен как причина хронического гастрита и язвы желудка и двенадцатиперстной кишки. Однако взаимодействие H. pylori и макроорганизма не ограничивается лишь слизистой оболочкой желудка – механизмы, определяющие адаптацию этой бактерии к условиям жизни в человеческом организме, могут вызывать системные нарушения иммунного равновесия, провоцируя развитие разнообразных аутоиммунных реакций. В статье рассмотрены исследования, демонстрирующие возможную роль H. pylori в качестве пускового или отягощающего фактора при ревматических заболеваниях, таких как ревматоидный артрит (РА), а также синдром и болезнь Шёгрена, системная красная волчанка и прогрессирующий системный склероз. Взаимосвязь между H. pylori и развитием аутоимунных заболеваний подтверждается большей частотой более агрессивных штаммов этого микроорганизма при ревматических заболеваниях. Имеются также клинические исследования, которые показывают позитивное влияние эрадикации H. pylori на активность РА.

Helicobacter pylori is the most common human infection. H. pylori is known to cause chronic gastritis and gastric and duodenal ulcers. However, the H. pylori-host interaction is not confined to the gastric mucosa, the mechanism responsible for the adaptation of this bacterium to the living conditions in the human body, can cause systemic immune imbalance, provoking various autoimmune reactions. The paper considers the investigations demonstrating the possible role of H. pylori as a trigger or aggravating factor in rheumatic diseases, such as rheumatoid arthritis (RA), Sjögren's syndrome and disease, systemic lupus erythematosus, and progressive systemic sclerosis. The relationship between H. pylori and autoimmune diseases is confirmed by the higher frequency of more aggressive strains of this microorganism in rheumatic diseases. There are also clinical trials showing the positive impact of H. pylori eradication on RA activity.

Helicobacter pyloriаутоиммунные заболеваниясиндром Шёгренаболезнь Шёгренасистемная красная волчанкапрогрессирующий системный склерозревматоидный артритсиндром Рейноактивность заболеванияэрадикация

Helicobacter pyloriautoimmune diseasesSjögren's syndromeSjögren's diseasesystemic lupus erythematosusprogressive systemic sclerosisrheumatoid arthritisRaynaud's syndromedisease activityeradication

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The authors declare that there are no conflicts of interest present.