mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2017-2-75-79mrj-759Research ArticleОБЗОРЫREVIEWSПрименение ингибитора фосфодиэстеразы 4 у пациентов с псориатическим артритомUse of phosphodiesterase 4 inhibitor in patients with psoriatic arthritisМазуровВ. И.MazurovV. I.

maz.nwgmu@yandex.ru

maz.nwgmu@yandex.ruТрофимовЕ. А.TrofimovE. A.maz.nwgmu@yandex.ruФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, Санкт-ПетербургРоссияI.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgRussian Federation2017250420171127579Copyright © Мазуров В.И., Трофимов Е.А., 20172017Мазуров В.И., Трофимов Е.А.Mazurov V.I., Trofimov E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/759

Псориатический артрит (ПсА) – хроническое воспалительное заболевание суставов, позвоночника и энтезисов, ассоциированное с псориазом. Патологический процесс локализуется преимущественно в тканях опорно-двигательного аппарата и приводит к развитию эрозивного артрита, внутрисуставного остеолиза и спондилоартрита. Для лечения ПсА применяют нестероидные противовоспалительные препараты, глюкокортикоиды, базисные противовоспалительные препараты (БПВП), генно-инженерные биологические препараты (ГИБП) и таргетные синтетические препараты (или блокаторы сигнальных путей). К последней группе препаратов относится апремиласт, ингибитор фосфодиэстеразы 4. Полученные к настоящему времени данные контролируемых исследований свидетельствуют о том, что апремиласт эффективен и безопасен при лечении псориаза и ПсА. Перспективы применения апремиласта при ПсА связаны с возможностью использовать препарат у пациентов с неэффективностью БПВП или ГИБП.

 

Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, spine, and entheses, which is associated with psoriasis. The pathological process is localized mainly in the tissues of the locomotor system and leads to the development of erosive arthritis, intra-articular osteolysis, and spondyloarthritis. Nonsteroidal anti-inflammatory drugs, glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), biological agents (BAs), and targeted synthetic drugs (or signaling pathway blockers) are used to treat PsA. The latter group of drugs includes apremilast, a phosphodiesterase 4 inhibitor. Recent data of controlled studies suggest that apremilast is effective and safe in treating psoriasis and PsA. Prospects for the use of apremilast in PsA are associated with the possibility of giving the drug to patients because of the inefficacy of DMARDs or BAs.

 

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The authors declare that there are no conflicts of interest present.