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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2017-3-81-84</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-779</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Опыт применения фебуксостата у пациента с тяжелой инвалидизирующей подагрой</article-title><trans-title-group xml:lang="en"><trans-title>Experience with febuxostat in a patient with severe disabling gout</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елисеев</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Eliseev</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><email xlink:type="simple">elicmax@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаяхметова</surname><given-names>Р. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Shayakhmetova</surname><given-names>R. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>26</day><month>09</month><year>2017</year></pub-date><volume>11</volume><issue>3</issue><fpage>81</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Елисеев М.С., Шаяхметова Р.У., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Елисеев М.С., Шаяхметова Р.У.</copyright-holder><copyright-holder xml:lang="en">Eliseev M.S., Shayakhmetova R.U.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/779">https://mrj.ima-press.net/mrj/article/view/779</self-uri><abstract><p>Подагра – хроническое заболевание, в случае неэффективной урат-снижающей терапии нередко приводящее к инвалидизации. В статье представлен положительный опыт применения у молодого пациента с хронической тофусной инвалидизирующей подагрой фебуксостата – нового непуринового ингибитора ксантиноксидазы. В результате 12-месячной терапии фебуксостатом в суточной дозе 80 мг было достигнуто практически полное рассасывание подкожных тофусов, наблюдалось длительное отсутствие приступов артрита при стойком сывороточном уровне мочевой кислоты ниже целевого. Это первый опыт успешной замены одного ингибитора ксантиноксидазы на другой, описанный после регистрации фебуксостата в Российской Федерации.</p></abstract><trans-abstract xml:lang="en"><p>Gout is a chronic disease that frequently leads to disability if urate-lowering therapy is inefficient. The paper presents the positive experience with febuxostat, a novel non-purine xanthine oxidase inhibitor, in a young patient with disabling chronic tophaceous gout. Twelve-month therapy with daily 80-mg dose of febuxostat resulted in almost complete resorption of subcutaneous tophi and in a long-term lack of arthritis attacks with the persistent serum uric acid levels below target ones. This is the first experience in successfully switching from one to another xanthine oxidase inhibitor, which was described after febuxostat registration in the Russian Federation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>подагра</kwd><kwd>мочевая кислота</kwd><kwd>тофусы</kwd><kwd>ингибитор ксантиноксидазы</kwd><kwd>фебуксостат</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gout</kwd><kwd>uric acid</kwd><kwd>tophi</kwd><kwd>xanthine oxidase inhibitor</kwd><kwd>febuxostat</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Насонова ВА, Барскова ВГ. Ранние диагностика и лечение подагры – научно обоснованное требование улучшения трудового и жизненного прогноза больных. Научно-практическая ревматология. 2004;42(1):5-7. [Nasonova VA, Barskova VG. Early diagnostic and treatment of gout – is scientifically based reguirements for improvement of labour and living prognosis of patients. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2004;42(1):5-7. (In Russ.)]. doi: 10.14412/1995-4484-2004-1374</mixed-citation><mixed-citation xml:lang="en">Насонова ВА, Барскова ВГ. Ранние диагностика и лечение подагры – научно обоснованное требование улучшения трудового и жизненного прогноза больных. Научно-практическая ревматология. 2004;42(1):5-7. [Nasonova VA, Barskova VG. Early diagnostic and treatment of gout – is scientifically based reguirements for improvement of labour and living prognosis of patients. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2004;42(1):5-7. (In Russ.)]. doi: 10.14412/1995-4484-2004-1374</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов ЕЛ, Елисеев МС. Роль интерлейкина 1 в развитии заболеваний человека. Научно-практическая ревматология. 2016; 54(1):60-77. [Nasonov EL, Eliseev MS. Role of interleukin 1 in the development of human diseases. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2016; 54(1):60-77. (In Russ.)]. doi: 10.14412/1995-4484-2016-60-77</mixed-citation><mixed-citation xml:lang="en">Насонов ЕЛ, Елисеев МС. Роль интерлейкина 1 в развитии заболеваний человека. Научно-практическая ревматология. 2016; 54(1):60-77. [Nasonov EL, Eliseev MS. Role of interleukin 1 in the development of human diseases. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2016; 54(1):60-77. (In Russ.)]. doi: 10.14412/1995-4484-2016-60-77</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Znu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011 Oct;63(10):3136-41. doi: 10.1002/art.30520.</mixed-citation><mixed-citation xml:lang="en">Znu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011 Oct;63(10):3136-41. doi: 10.1002/art.30520.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Trifiro G, Morabito P, Cavagna L, et al. Epidemiology of gout and hyperuricemia in Italy during the years 2005-2009: a nationwide population-based study. Ann Rheum Dis. 2013 May;72(5):694-700. doi: 10.1136/annrheumdis-2011-201254. Epub 2012 Jun 26.</mixed-citation><mixed-citation xml:lang="en">Trifiro G, Morabito P, Cavagna L, et al. Epidemiology of gout and hyperuricemia in Italy during the years 2005-2009: a nationwide population-based study. Ann Rheum Dis. 2013 May;72(5):694-700. doi: 10.1136/annrheumdis-2011-201254. Epub 2012 Jun 26.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kuo CF, Grainge MJ, Mallen D, et al. Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Ann Rheum Dis. 2015 Apr;74(4):661-7. doi: 10.1136/annrheumdis-2013-204463. Epub 2014 Jan 15.</mixed-citation><mixed-citation xml:lang="en">Kuo CF, Grainge MJ, Mallen D, et al. Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Ann Rheum Dis. 2015 Apr;74(4):661-7. doi: 10.1136/annrheumdis-2013-204463. Epub 2014 Jan 15.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bardin T, Bouee S, Clerson P, et al. Prevalence of gout in the Adult Population of France. Arthritis Care Res (Hoboken). 2016 Feb;68(2):261-6. doi: 10.1002/acr.22660.</mixed-citation><mixed-citation xml:lang="en">Bardin T, Bouee S, Clerson P, et al. Prevalence of gout in the Adult Population of France. Arthritis Care Res (Hoboken). 2016 Feb;68(2):261-6. doi: 10.1002/acr.22660.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017 Jan;76(1):29-42. doi: 10.1136/annrheumdis-2016-209707. Epub 2016 Jul 25.</mixed-citation><mixed-citation xml:lang="en">Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017 Jan;76(1):29-42. doi: 10.1136/annrheumdis-2016-209707. Epub 2016 Jul 25.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Khanna D, FitzGerald JD, Khanna PP, et al. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken). 2012 Oct;64(10):1431-46. doi: 10.1002/acr.21772.</mixed-citation><mixed-citation xml:lang="en">Khanna D, FitzGerald JD, Khanna PP, et al. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken). 2012 Oct;64(10):1431-46. doi: 10.1002/acr.21772.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Harrold LR, Andrade SE, Briesacher BA, et al. Adherence with urate-lowering therapies for the treatment of gout. Arthritis Care Res (Hoboken). 2012 Oct;64(10): 1431-46. doi: 10.1002/acr.21772.</mixed-citation><mixed-citation xml:lang="en">Harrold LR, Andrade SE, Briesacher BA, et al. Adherence with urate-lowering therapies for the treatment of gout. Arthritis Care Res (Hoboken). 2012 Oct;64(10): 1431-46. doi: 10.1002/acr.21772.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Елисеев МС. Подагра. В кн.: Ревматология. Клинические российские рекомендации. Москва: ГЭОТАР-Медиа; 2017. С. 253-64. [Eliseev MS. Gout. In: Revmatologiya. Klinicheskie rossiiskie rekomendatsii [Rheumatology. Russian clinical recommendations]. Moscow: GEOTAR-Media; 2017. P. 253-64.]</mixed-citation><mixed-citation xml:lang="en">Елисеев МС. Подагра. В кн.: Ревматология. Клинические российские рекомендации. Москва: ГЭОТАР-Медиа; 2017. С. 253-64. [Eliseev MS. Gout. In: Revmatologiya. Klinicheskie rossiiskie rekomendatsii [Rheumatology. Russian clinical recommendations]. Moscow: GEOTAR-Media; 2017. P. 253-64.]</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Riedel AA, Nelson M, Joseph-Ridge N, et al. Compliance with allopurinol therapy among managed care enrollees with gout: a retrospective analysis of administrative claims. J Rheumatol. 2004 Aug;31(8):1575-81.</mixed-citation><mixed-citation xml:lang="en">Riedel AA, Nelson M, Joseph-Ridge N, et al. Compliance with allopurinol therapy among managed care enrollees with gout: a retrospective analysis of administrative claims. J Rheumatol. 2004 Aug;31(8):1575-81.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Stamp L, Merriman T, Barclay M, et al. Impaired response or insufficient dosage? Examining the potential causes of 'inadequate response' to allopurinol in the treatment of gout. Semin Arthritis Rheum. 2014 Oct;44(2): 170-4. doi: 10.1016/j.semarthrit.2014.05.007. Epub 2014 May 9.</mixed-citation><mixed-citation xml:lang="en">Stamp L, Merriman T, Barclay M, et al. Impaired response or insufficient dosage? Examining the potential causes of 'inadequate response' to allopurinol in the treatment of gout. Semin Arthritis Rheum. 2014 Oct;44(2): 170-4. doi: 10.1016/j.semarthrit.2014.05.007. Epub 2014 May 9.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Елисеев МС, Барскова ВГ, Денисов ИС. Динамика клинических проявлений подагры у мужчин (данные 7-летнего ретроспективного наблюдения). Терапевтический архив. 2015; 87(5):10-5. [Eliseev MS, Barskova VG, Denisov IS. Dynamics of clinical manifestations of gout in men (data from 7-year retrospective surveillance). Terapevticheskii arkhiv. 2015; 87(5):10-5. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Елисеев МС, Барскова ВГ, Денисов ИС. Динамика клинических проявлений подагры у мужчин (данные 7-летнего ретроспективного наблюдения). Терапевтический архив. 2015; 87(5):10-5. [Eliseev MS, Barskova VG, Denisov IS. Dynamics of clinical manifestations of gout in men (data from 7-year retrospective surveillance). Terapevticheskii arkhiv. 2015; 87(5):10-5. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Echteld IA, Durme C, Falzon L, et al. Treatment of Gout Patients with Impairment of Renal Function: A Systematic Literature Review. J Rheum. Suppl. 2014; 92:48-54.</mixed-citation><mixed-citation xml:lang="en">Echteld IA, Durme C, Falzon L, et al. Treatment of Gout Patients with Impairment of Renal Function: A Systematic Literature Review. J Rheum. Suppl. 2014; 92:48-54.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Елисеев МС, Денисов ИС, Маркелова ЕИ и др. Независимые факторы риска развития тяжелых сердечно-сосудистых осложнений у мужчин с подагрой: результаты 7-летнего проспективного наблюдения. Терапевтический архив. 2017; 89(5):10-9. [Eliseev MS, Denisov IS, Markelova EI, et al. Independent risk factors for development of severe cardiovascular complications in men with gout: results of a 7-year prospective study. Terapevticheskii arkhiv. 2017; 89(5):10-9. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Елисеев МС, Денисов ИС, Маркелова ЕИ и др. Независимые факторы риска развития тяжелых сердечно-сосудистых осложнений у мужчин с подагрой: результаты 7-летнего проспективного наблюдения. Терапевтический архив. 2017; 89(5):10-9. [Eliseev MS, Denisov IS, Markelova EI, et al. Independent risk factors for development of severe cardiovascular complications in men with gout: results of a 7-year prospective study. Terapevticheskii arkhiv. 2017; 89(5):10-9. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Tsuruta Y, Mochizuki T, Moriyama T, et al. Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease. Clin Rheumatol. 2014 Nov;33(11): 1643-8. doi: 10.1007/s10067-014-2745-5. Epub 2014 Jul 22.</mixed-citation><mixed-citation xml:lang="en">Tsuruta Y, Mochizuki T, Moriyama T, et al. Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease. Clin Rheumatol. 2014 Nov;33(11): 1643-8. doi: 10.1007/s10067-014-2745-5. Epub 2014 Jul 22.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Altan A, Shiozawa A, Bancroft T, Singh JA. A real-world study of switching from allopurinol to febuxostat in a health plan database. J Clin Rheumatol. 2015 Dec;21(8): 411-8. doi: 10.1097/RHU.0000000000000322.</mixed-citation><mixed-citation xml:lang="en">Altan A, Shiozawa A, Bancroft T, Singh JA. A real-world study of switching from allopurinol to febuxostat in a health plan database. J Clin Rheumatol. 2015 Dec;21(8): 411-8. doi: 10.1097/RHU.0000000000000322.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lopez Lopez CO, Lugo EF, Alvarez-Hernаndez E, et al. Severe tophaceous gout and disability: changes in the past 15 years. Clin Rheumatol. 2017 Jan;36(1):199-204. doi: 10.1007/s10067-016-3381-z. Epub 2016 Sep 8.</mixed-citation><mixed-citation xml:lang="en">Lopez Lopez CO, Lugo EF, Alvarez-Hernаndez E, et al. Severe tophaceous gout and disability: changes in the past 15 years. Clin Rheumatol. 2017 Jan;36(1):199-204. doi: 10.1007/s10067-016-3381-z. Epub 2016 Sep 8.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Doherty M, Jansen TL, Nuki G, et al. Gout: why is this curable disease so seldom cured? Ann Rheum Dis. 2012 Nov;71(11): 1765-70. doi: 10.1136/annrheumdis-2012- 201687. Epub 2012 Aug 3.</mixed-citation><mixed-citation xml:lang="en">Doherty M, Jansen TL, Nuki G, et al. Gout: why is this curable disease so seldom cured? Ann Rheum Dis. 2012 Nov;71(11): 1765-70. doi: 10.1136/annrheumdis-2012- 201687. Epub 2012 Aug 3.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Li S, Yang H, Guo Y, et al. Comparative efficacy and safety of urate-lowering therapy for the treatment of hyperuricemia: a systematic review and network metaanalysis. Sci Rep. 2016 Sep 8;6:33082. doi: 10.1038/srep33082.</mixed-citation><mixed-citation xml:lang="en">Li S, Yang H, Guo Y, et al. Comparative efficacy and safety of urate-lowering therapy for the treatment of hyperuricemia: a systematic review and network metaanalysis. Sci Rep. 2016 Sep 8;6:33082. doi: 10.1038/srep33082.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Stamp LK, Chapman PT, Barclay ML, et al. A randomised controlled trial of the efficacy and safety of allopurinol dose escalation to achieve target serum urate in people with gout. Ann Rheum Dis. 2017 Sep;76(9):1522-1528. doi: 10.1136/annrheumdis-2016-210872. Epub 2017 Mar 17.</mixed-citation><mixed-citation xml:lang="en">Stamp LK, Chapman PT, Barclay ML, et al. A randomised controlled trial of the efficacy and safety of allopurinol dose escalation to achieve target serum urate in people with gout. Ann Rheum Dis. 2017 Sep;76(9):1522-1528. doi: 10.1136/annrheumdis-2016-210872. Epub 2017 Mar 17.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rai SK, Avina-Zubieta JA, McCormick N, et al. Trends in Gout and Rheumatoid Arthritis Hospitalizations in Canada From 2000 to 2011. Arthritis Care Res (Hoboken). 2017 May;69(5):758-762. doi: 10.1002/acr.23012.</mixed-citation><mixed-citation xml:lang="en">Rai SK, Avina-Zubieta JA, McCormick N, et al. Trends in Gout and Rheumatoid Arthritis Hospitalizations in Canada From 2000 to 2011. Arthritis Care Res (Hoboken). 2017 May;69(5):758-762. doi: 10.1002/acr.23012.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lim SY, Lu N, Oza A, et al. Trends in Gout and Rheumatoid Arthritis Hospitalizations in the United States, 1993-2011. JAMA. 2016 Jun 7;315(21): 2345-7. doi: 10.1001/jama.2016.3517.</mixed-citation><mixed-citation xml:lang="en">Lim SY, Lu N, Oza A, et al. Trends in Gout and Rheumatoid Arthritis Hospitalizations in the United States, 1993-2011. JAMA. 2016 Jun 7;315(21): 2345-7. doi: 10.1001/jama.2016.3517.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Love BL, Barrons R, Veverka A, Snider KM. Urate-lowering therapy for gout: Focus on febuxostat. Pharmacotherapy. 2010 Jun;30(6):594-608. doi: 10.1592/phco.30.6.594.</mixed-citation><mixed-citation xml:lang="en">Love BL, Barrons R, Veverka A, Snider KM. Urate-lowering therapy for gout: Focus on febuxostat. Pharmacotherapy. 2010 Jun;30(6):594-608. doi: 10.1592/phco.30.6.594.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Becker MA, Schumacher H, Wortmann R, et al. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med. 2005 Dec 8;353(23):2450-61.</mixed-citation><mixed-citation xml:lang="en">Becker MA, Schumacher H, Wortmann R, et al. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med. 2005 Dec 8;353(23):2450-61.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Shibagaki Y, Ohno I, Hosoya T, Kimura K. Safety, efficacy and renal effect of febuxostat in patients with moderateto- severe kidney dysfunction. Hypertens Res. 2014 Oct;37(10):919-25. doi: 10.1038/hr.2014.107. Epub 2014 Jun 19.</mixed-citation><mixed-citation xml:lang="en">Shibagaki Y, Ohno I, Hosoya T, Kimura K. Safety, efficacy and renal effect of febuxostat in patients with moderateto- severe kidney dysfunction. Hypertens Res. 2014 Oct;37(10):919-25. doi: 10.1038/hr.2014.107. Epub 2014 Jun 19.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Whelton A, MacDonald PA, Chefo S, Gunawardhana L. Preservation of renal function during gout treatment with febuxostat: a quantitative study. Postgrad Med. 2013 Jan;125(1):106-14. doi: 10.3810/pgm.2013.01.2626.</mixed-citation><mixed-citation xml:lang="en">Whelton A, MacDonald PA, Chefo S, Gunawardhana L. Preservation of renal function during gout treatment with febuxostat: a quantitative study. Postgrad Med. 2013 Jan;125(1):106-14. doi: 10.3810/pgm.2013.01.2626.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Becker MA, Schumacher HR Jr, Wortmann RL, et al. Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, phase II, randomized, double- blind, placebocontrolled, doseresponse clinical trial examining safety and efficacy in patients with gout. Arthritis Rheum. 2005 Mar;52(3):916-23.</mixed-citation><mixed-citation xml:lang="en">Becker MA, Schumacher HR Jr, Wortmann RL, et al. Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, phase II, randomized, double- blind, placebocontrolled, doseresponse clinical trial examining safety and efficacy in patients with gout. Arthritis Rheum. 2005 Mar;52(3):916-23.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
