References

mrj

Современная ревматология

Modern Rheumatology Journal

1996-70122310-158X

IMA-PRESS, LLC

10.14412/1996-7012-2017-3-106-111

mrj-783

Research Article

ОБЗОРЫ

REVIEWS

Выбор терапевтической тактики при неэффективности первого ингибитора фактора некроза опухоли α

Choice of therapeutic tactics after failure of the first tumor necrosis factor-α inhibitor

Чичасова

Н. В.

Chichasova

N. V.

Кафедра ревматологии ИПО

119991, Москва, ул. Трубецкая, 8, стр.2

Department of Rheumatology

8, Trubetskaya St., Build. 2, Moscow 119991

kafedrarheum@ya.ru

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»РоссияInstitute of Professional Education, I.M. Sechenov First Moscow State Medical UniversityRussian Federation

2017

26092017

113106111

2017

Чичасова Н.В.

Chichasova N.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://mrj.ima-press.net/mrj/article/view/783

В статье обсуждается возможность достижения эффекта различных генно-инженерных биологических препаратов (ГИБП) у пациентов с активным ревматоидным артритом (РА) при неадекватном ответе на терапию ингибиторами фактора некроза опухоли α (иФНОα). Представлены данные об эффективности у данной группы больных ГИБП с другим механизмом действия (абатацепт, тоцилизумаб, ритуксимаб) и сопоставимой с ними эффективности голимумаба (ГЛМ). Показано, что эффект терапии ГЛМ не зависит от причин отмены предшествующего иФНОα (неэффективность, нежелательные явления и др.). Сделан вывод об эффективности ГЛМ при предшествующем неудачном лечении одним или двумя иФНОα.

The paper discusses whether the effect of different biological agents (BAs) can be achieved in patients with active rheumatoid arthritis (RA) when they inadequately respond to therapy with tumor necrosis factor-α (TNF-α) inhibitors. It gives data on the efficacy of BAs with another mechanism of action (abatacept, tocilizumab, and rituximab) and on the comparable efficacy of golimumab (GLM) in this group of patients. It is shown that the effect of GLM therapy does not depend on the reasons for discontinuation of a previously used TNF-α inhibitors (inefficacy, adverse events, etc.). It is conclusion that GLM is effective after failure of one or two TNF-α inhibitors.

ревматоидный артритгенно-инженерные биологические препаратыголимумабизменение терапиинеэффективность или непереносимость ингибиторов фактора некроза опухоли α

rheumatoid arthritisbiological agentsgolimumabtherapy modificationinefficacy of or intolerance to tumor necrosis factor-α inhibitors.

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The authors declare that there are no conflicts of interest present.