References

mrj

Современная ревматология

Modern Rheumatology Journal

1996-70122310-158X

IMA-PRESS, LLC

10.14412/1996-7012-2018-1-73-77

mrj-812

Research Article

ОБЗОРЫ

REVIEWS

Остеоартрит суставов кисти: диагностика, патогенез, лечение

Hand osteoarthritis: diagnosis, pathogenesis, treatment

Балабанова

Р. М.

Balabanova

R. M.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

balabanova@irramn.ru

Смирнов

А. В.

Smirnov

A. V.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

Кудинский

Д. М.

Kudinsky

D. M.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

Алексеева

Л. И.

Alekseeva

L. I.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation

2018

02042018

1217377

2018

Балабанова Р.М., Смирнов А.В., Кудинский Д.М., Алексеева Л.И.

Balabanova R.M., Smirnov A.V., Kudinsky D.M., Alekseeva L.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://mrj.ima-press.net/mrj/article/view/812

На ранних стадиях остеоартрит кисти (ОАК) из-за развития синовита напоминает поражение суставов кисти при ревматоидном артрите (РА). Однако локализация синовита при этих заболеваниях различна: при ОАК в процесс вовлечены дистальные межфаланговые суставы и суставы большого пальца. При ОАК отрицательны результаты тестов на иммунологические маркеры (антитела к цитруллинированному пептиду), что типично для РА. Различия ОАК и РА очевидны при рентгенографии и магнитно-резонансной томографии кисти. Изучение патогенеза остеоартрита (ОА) свидетельствует о роли дисбаланса цитокинового профиля, что сближает его с РА. Терапия ОАК практически не разработана, имеются лишь отдельные исследования, посвященные применению базисных противовоспалительных и биологических препаратов у таких пациентов. Отмечена необходимость создания отечественных рекомендаций по лечению ОАК.

Due to the development of synovitis, early-stage hand osteoarthritis (HOA) mimics hand joint injury in rheumatoid arthritis (RA). However, the topography of synovitis is diverse in these diseases: distal interphalangeal and thumb joints are involved in the process in HOA. In the latter, tests are negative for immunological markers (anti-cyclic citrullinated peptide antibodies), which is typical of RA. The differences between HOA and RA are prominent, as evidenced by hand X-rays and magnetic resonance imaging. Investigations suggest that cytokine profile imbalance is implicated in the pathogenesis of osteoarthritis, which brings it closer to RA. However, therapy for HOA has not been practically developed; there are only a few works on the use of disease-modifying antirheumatic drugs and biological agents in these patients. It is necessary to work out Russian guidelines for the treatment of HOA.

остеоартрит кистииммуноопосредованные механизмы патогенезанефармакологические методы леченияметотрексатгидроксихлорохинбиологические препараты

hand osteoarthritisimmune-mediated mechanisms of pathogenesisnon-pharmacological treatmentsmethotrexatehydroxychloroquinebiological agents

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The authors declare that there are no conflicts of interest present.