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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2018-2-22-35</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-822</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Псориатический артрит. Клинические рекомендации по диагностике и лечению</article-title><trans-title-group xml:lang="en"><trans-title>Psoriatic arthritis. Clinical guidelines for diagnosis and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коротаева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korotaeva</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><email xlink:type="simple">tatianakorotaeva@googlemail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корсакова</surname><given-names>Ю. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Korsakova</surname><given-names>Yu. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логинова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Loginova</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Губарь</surname><given-names>Е. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Gubar</surname><given-names>E. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чамурлиева</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Chamurlieva</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>06</day><month>06</month><year>2018</year></pub-date><volume>12</volume><issue>2</issue><fpage>22</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коротаева Т.В., Корсакова Ю.Л., Логинова Е.Ю., Губарь Е.Е., Чамурлиева М.Н., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Коротаева Т.В., Корсакова Ю.Л., Логинова Е.Ю., Губарь Е.Е., Чамурлиева М.Н.</copyright-holder><copyright-holder xml:lang="en">Korotaeva T.V., Korsakova Y.L., Loginova E.Y., Gubar E.E., Chamurlieva M.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/822">https://mrj.ima-press.net/mrj/article/view/822</self-uri><abstract><p>В последние годы отмечается значительный рост заболеваемости псориатическим артритом (ПсА), увеличивается число случаев его тяжелого течения, что приводит к выраженному ухудшению качества жизни (КЖ) пациентов, потере трудоспособности и ранней инвалидизации.</p><p>ПсА характеризуется хроническим прогрессирующим течением, развитием деструкции и анкилозирования суставов, множественного внутрисуставного остеолиза, спондилита, часто сопровождается разнообразной коморбидной патологией. Важными аспектами профилактики функциональных нарушений и эрозирования суставов, успешной терапии являются ранняя диагностика ПсА у больных псориазом (Пс), а также своевременная консультация пациента ревматологом.</p><p>Раннее назначение патогенетически обоснованной терапии ПсА позволяет снизить вероятность необратимого повреждения суставов, позвоночника и внутренних органов у таких пациентов. Основная цель фармакотерапии ПсА – достижение ремиссии или минимальной активности заболевания (артрита, спондилита, энтезита, дактилита, Пс), замедление или предупреждение рентгенологического прогрессирования, увеличение продолжительности жизни и улучшение КЖ пациентов, а также снижение риска коморбидных заболеваний. Данные рекомендации разработаны совместно ревматологами и дерматовенерологами с целью улучшения диагностики ПсА у больных Пс и своевременного назначения адекватной терапии. </p></abstract><trans-abstract xml:lang="en"><p>In recent years, there has been a considerable rise in the incidence of psoriatic arthritis (PsA) and an increase in the number of cases of its severe course, which leads to the marked deterioration of quality of life (QL), to disability and early disability.</p><p>PsA is characterized by its chronic progressive course, the development of joint destruction and ankylosis, multiple intra-articular osteolysis, spondylitis and frequently accompanied by various comorbidities. The important aspects of the prevention of joint functional disorders and erosion and their successful therapy are early diagnosis of PsA in patients with psoriasis (Ps) and timely consultation with a rheumatologist.</p><p>The early use of pathogenetically sound therapy for PsA reduces the likelihood of irreversible damage to the joints, spine, and viscera in these patients. The main goal of PsA pharmacotherapy is to achieve remission or minimal activity of a disease (arthritis, spondylitis, enthesitis, dactylitis, and Ps), to slow or prevent radiological progression, to increase life expectancy, to improve QL for patients, and to lower the risk of comorbidities.</p><p>These guidelines have been worked out jointly by rheumatologists and dermatovenereologists in order to improve the diagnosis of PsA in patients with Ps and to timely initiate adequate therapy. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>псориатический артрит</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>клинические рекомендации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>psoriatic arthritis</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>clinical guidelines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Коротаева ТВ. Псориатический артрит: классификация, клиническая картина, диагностика, лечение. Научно-практическая ревматология. 2014;52(6):650-9. [Korotaeva TV. Psoriatic arthritis: classification, clinical presentation, diagnosis, treatment. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2014;52(6):650-9. (In Russ.)]. doi: 10.14412/ 1995-4484-2014-650-659</mixed-citation><mixed-citation xml:lang="en">Коротаева ТВ. Псориатический артрит: классификация, клиническая картина, диагностика, лечение. Научно-практическая ревматология. 2014;52(6):650-9. [Korotaeva TV. Psoriatic arthritis: classification, clinical presentation, diagnosis, treatment. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2014;52(6):650-9. (In Russ.)]. doi: 10.14412/ 1995-4484-2014-650-659</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Gladman DD, Antoni C, Mease P, et al. Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis. 2005 Mar;64 Suppl 2:ii14-7.</mixed-citation><mixed-citation xml:lang="en">Gladman DD, Antoni C, Mease P, et al. Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis. 2005 Mar;64 Suppl 2:ii14-7.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Мишина ОС, Коротаева ТВ. Заболеваемость псориатическим артритом в Российской Федерации: тенденции на современном этапе и перспективы. Научно-практическая ревматология. 2015;(53)3: 251-7. [Mishina OS, Korotaeva TV. Incidence of psoriatic arthritis in Russia: trends at the present stage and prospects. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2015;(53)3: 251-7. (In Russ.)]. doi: 10.14412/1995-4484-2015-251-257</mixed-citation><mixed-citation xml:lang="en">Мишина ОС, Коротаева ТВ. Заболеваемость псориатическим артритом в Российской Федерации: тенденции на современном этапе и перспективы. Научно-практическая ревматология. 2015;(53)3: 251-7. [Mishina OS, Korotaeva TV. Incidence of psoriatic arthritis in Russia: trends at the present stage and prospects. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2015;(53)3: 251-7. (In Russ.)]. doi: 10.14412/1995-4484-2015-251-257</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Баткаева НВ, Коротаева ТВ, Баткаев ЭА. Структура кардиоваскулярной коморбидности у больных тяжелыми формами псориаза: данные ретроспективного анализа госпитальной когорты. Научно-практическая ревматология. 2017;55(5):493-9. [Batkaeva NV, Korotaeva TV, Batkaev EA. The pattern of cardiovascular comorbidity in patients with severe forms of psoriasis: data of retrospective analysis of a hospital cohort. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2017;55(5):493-9. (In Russ.)]. doi: 10.14412/1995-4484-2017-493-499</mixed-citation><mixed-citation xml:lang="en">Баткаева НВ, Коротаева ТВ, Баткаев ЭА. Структура кардиоваскулярной коморбидности у больных тяжелыми формами псориаза: данные ретроспективного анализа госпитальной когорты. Научно-практическая ревматология. 2017;55(5):493-9. [Batkaeva NV, Korotaeva TV, Batkaev EA. The pattern of cardiovascular comorbidity in patients with severe forms of psoriasis: data of retrospective analysis of a hospital cohort. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2017;55(5):493-9. (In Russ.)]. doi: 10.14412/1995-4484-2017-493-499</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kristensen LE, Jorgensen TD, Christensen R, et al Societal costs and patients‘ experience of health inequities before and after diagnosis of psoriatic arthritis: a Danish cohort study. Ann Rheum Dis. 2017 Sep;76(9):1495-1501. doi: 10.1136/ annrheumdis-2016-210579. Epub 2017 Jan 30.</mixed-citation><mixed-citation xml:lang="en">Kristensen LE, Jorgensen TD, Christensen R, et al Societal costs and patients‘ experience of health inequities before and after diagnosis of psoriatic arthritis: a Danish cohort study. Ann Rheum Dis. 2017 Sep;76(9):1495-1501. doi: 10.1136/ annrheumdis-2016-210579. Epub 2017 Jan 30.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Olivieri I, Padula A, D’Angelo S, et al. Psoriatic arthritis sine psoriasis. J Rheumatol Suppl. 2009 Aug;83:28-9. doi: 10.3899/jrheum. 090218.</mixed-citation><mixed-citation xml:lang="en">Olivieri I, Padula A, D’Angelo S, et al. Psoriatic arthritis sine psoriasis. J Rheumatol Suppl. 2009 Aug;83:28-9. doi: 10.3899/jrheum. 090218.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mease PJ. Psoriatic Arthritis: update on pathophysiology, assessement and management. Ann Rheum Dis. 2011 Mar;70 Suppl 1:i77-84. doi: 10.1136/ard.2010.140582..</mixed-citation><mixed-citation xml:lang="en">Mease PJ. Psoriatic Arthritis: update on pathophysiology, assessement and management. Ann Rheum Dis. 2011 Mar;70 Suppl 1:i77-84. doi: 10.1136/ard.2010.140582..</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Love TJ, Zhu Y, Zhang Y, et al. Obesity and the risk of psoriatic arthritis: a population-based study. Ann Rheum Dis. 2012 Aug; 71(8):1273-7. doi: 10.1136/annrheumdis2012-201299. Epub 2012 May 14.</mixed-citation><mixed-citation xml:lang="en">Love TJ, Zhu Y, Zhang Y, et al. Obesity and the risk of psoriatic arthritis: a population-based study. Ann Rheum Dis. 2012 Aug; 71(8):1273-7. doi: 10.1136/annrheumdis2012-201299. Epub 2012 May 14.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Moll J, Wright V. Psoriatic arthritis. Semin Arthritis Rheum. 1973;3(1):55-78.</mixed-citation><mixed-citation xml:lang="en">Moll J, Wright V. Psoriatic arthritis. Semin Arthritis Rheum. 1973;3(1):55-78.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sieper J, van der Heijde DM, Landewe R, et al. New criteria for inflammatory back pain in patients with chronic back pain: a real patient exercise by experts from the Assessment of SpondyloArthritis international Society (ASAS). Ann Rheum Dis. 2009 Jun; 68(6):784-8. doi: 10.1136/ard.2008.101501. Epub 2009 Jan 15.</mixed-citation><mixed-citation xml:lang="en">Sieper J, van der Heijde DM, Landewe R, et al. New criteria for inflammatory back pain in patients with chronic back pain: a real patient exercise by experts from the Assessment of SpondyloArthritis international Society (ASAS). Ann Rheum Dis. 2009 Jun; 68(6):784-8. doi: 10.1136/ard.2008.101501. Epub 2009 Jan 15.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lubrano E, Marchesoni A, Olivieri I, et al. The radiological assessment of axial involvement in psoriatic arthritis: a validation study of the BASRI total and the modified SASSS scoring methods. Clin Exp Rheumatol. 2009 Nov-Dec;27(6):977-80.</mixed-citation><mixed-citation xml:lang="en">Lubrano E, Marchesoni A, Olivieri I, et al. The radiological assessment of axial involvement in psoriatic arthritis: a validation study of the BASRI total and the modified SASSS scoring methods. Clin Exp Rheumatol. 2009 Nov-Dec;27(6):977-80.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor W, Gladman D, Helliwell P, et al. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum. 2006 Aug;54(8):2665-73.</mixed-citation><mixed-citation xml:lang="en">Taylor W, Gladman D, Helliwell P, et al. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum. 2006 Aug;54(8):2665-73.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ibrahim GH, Buch MH, Lawson C, et al. Evaluation of an existing screening tool for psoriatic arthritis in people with psoriasis and the development of a new instrument: the Psoriasis Epidemiology Screening Tool (PEST) questionnaire. Clin Exp Rheumatol. 2009 May-Jun;27(3):469-74.</mixed-citation><mixed-citation xml:lang="en">Ibrahim GH, Buch MH, Lawson C, et al. Evaluation of an existing screening tool for psoriatic arthritis in people with psoriasis and the development of a new instrument: the Psoriasis Epidemiology Screening Tool (PEST) questionnaire. Clin Exp Rheumatol. 2009 May-Jun;27(3):469-74.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Чамурлиева МН, Логинова ЕЮ, Коротаева ТВ, Баткаев ЭА. Особенности поражения костно-суставного аппарата у больных псориазом по данным скринингового опросника PEST (Psoriasis Epydemiology Screening Tool). Вестник последипломного медицинского образования. 2014;(2): 16-20. [Chamurlieva MN, Loginova EYu, Korotaeva TV, Batkaev EA. Features of lesions of the musculoskeletal system in patients with psoriasis according to the screening questionnaire PEST (Psoriasis Epydemiology Screening Tool). Vestnik poslediplomnogo meditsinskogo obrazovaniya. 2014;(2):16-20. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Чамурлиева МН, Логинова ЕЮ, Коротаева ТВ, Баткаев ЭА. Особенности поражения костно-суставного аппарата у больных псориазом по данным скринингового опросника PEST (Psoriasis Epydemiology Screening Tool). Вестник последипломного медицинского образования. 2014;(2): 16-20. [Chamurlieva MN, Loginova EYu, Korotaeva TV, Batkaev EA. Features of lesions of the musculoskeletal system in patients with psoriasis according to the screening questionnaire PEST (Psoriasis Epydemiology Screening Tool). Vestnik poslediplomnogo meditsinskogo obrazovaniya. 2014;(2):16-20. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Чамурлиева МН, Логинова ЕЮ, Коротаева ТВ. Выявляемость псориатического артрита у больных псориазом в дерматологической и ревматологической клинике. Современная ревматология. 2016;10(4): 47-50. [Chamurlieva MN, Loginova EYu, Korotaeva TV. Detection rates of psoriatic arthritis in patients with psoriasis in a dermatology and rheumatology clinic. Sovremennaya revmatologiya = Modern Rheumatology Journal. 2016;10(4):47-50. (In Russ.)]. doi: 10.14412/1996-7012-2016-4-47-50</mixed-citation><mixed-citation xml:lang="en">Чамурлиева МН, Логинова ЕЮ, Коротаева ТВ. Выявляемость псориатического артрита у больных псориазом в дерматологической и ревматологической клинике. Современная ревматология. 2016;10(4): 47-50. [Chamurlieva MN, Loginova EYu, Korotaeva TV. Detection rates of psoriatic arthritis in patients with psoriasis in a dermatology and rheumatology clinic. Sovremennaya revmatologiya = Modern Rheumatology Journal. 2016;10(4):47-50. (In Russ.)]. doi: 10.14412/1996-7012-2016-4-47-50</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gladman DD, Helliwell P, Mease PJ, et al. Assessment of Patients With Psoriatic Arthritis. Arthritis Rheum. 2004 Jan;50(1):24-35.</mixed-citation><mixed-citation xml:lang="en">Gladman DD, Helliwell P, Mease PJ, et al. Assessment of Patients With Psoriatic Arthritis. Arthritis Rheum. 2004 Jan;50(1):24-35.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Schoels MM, Aletaha D, Alasti F, et al. Disease activity in psoriatic arthritis (PsA): defining remission and treatment success using the DAPSA score. Ann Rheum Dis. 2016 May;75(5):811-8. doi: 10.1136/annrheumdis2015-207507. Epub 2015 Aug 12.</mixed-citation><mixed-citation xml:lang="en">Schoels MM, Aletaha D, Alasti F, et al. Disease activity in psoriatic arthritis (PsA): defining remission and treatment success using the DAPSA score. Ann Rheum Dis. 2016 May;75(5):811-8. doi: 10.1136/annrheumdis2015-207507. Epub 2015 Aug 12.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gossec L, Smolen J, Gaujoux-Viala C, et al. European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies. Ann Rheum Dis. 2012 Jan;71(1):4-12. doi: 10.1136/annrheumdis-2011-200350. Epub 2011 Sep 27.</mixed-citation><mixed-citation xml:lang="en">Gossec L, Smolen J, Gaujoux-Viala C, et al. European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies. Ann Rheum Dis. 2012 Jan;71(1):4-12. doi: 10.1136/annrheumdis-2011-200350. Epub 2011 Sep 27.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Fries JF, Spitz PW, Kraines RG, et al. Measurement of patient outcome in arthritis. Arthritis Rheum. 1980 Feb;23(2):137-45.</mixed-citation><mixed-citation xml:lang="en">Fries JF, Spitz PW, Kraines RG, et al. Measurement of patient outcome in arthritis. Arthritis Rheum. 1980 Feb;23(2):137-45.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Felson DT, Andersen JJ, Boers M, et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 1995 Jun;38(6): 727-35.</mixed-citation><mixed-citation xml:lang="en">Felson DT, Andersen JJ, Boers M, et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 1995 Jun;38(6): 727-35.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Clegg DO, Reda DJ, Mejias E, et al. Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis: a Department Veterans Affairs Cooperative Study. Arthritis Rheum. 1996 Dec;39(12):2013-20.</mixed-citation><mixed-citation xml:lang="en">Clegg DO, Reda DJ, Mejias E, et al. Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis: a Department Veterans Affairs Cooperative Study. Arthritis Rheum. 1996 Dec;39(12):2013-20.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Garret SL, Jenkinson TR, Whitelock HC, et al. A new approach to defining disease status in ankylosing spondylitis: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). J Rheumatol. 1994 Dec;21(12):2286-91.</mixed-citation><mixed-citation xml:lang="en">Garret SL, Jenkinson TR, Whitelock HC, et al. A new approach to defining disease status in ankylosing spondylitis: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). J Rheumatol. 1994 Dec;21(12):2286-91.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Healy PJ, Helliwell PS. Measuring clinical enthesitis in psoriatic arthritis: assessment of existing measures and development of an instrument specific to psoriatic arthritis. Arthritis Rheum. 2008 May 15;59(5):686-91. doi: 10.1002/art.23568.</mixed-citation><mixed-citation xml:lang="en">Healy PJ, Helliwell PS. Measuring clinical enthesitis in psoriatic arthritis: assessment of existing measures and development of an instrument specific to psoriatic arthritis. Arthritis Rheum. 2008 May 15;59(5):686-91. doi: 10.1002/art.23568.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Coates LC, Kavanaugh A, Mease PJ, et al. Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis. Arthritis Rheumatol. 2016 May;68(5): 1060-71. doi: 10.1002/art.39573. Epub 2016 Mar 23.</mixed-citation><mixed-citation xml:lang="en">Coates LC, Kavanaugh A, Mease PJ, et al. Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis. Arthritis Rheumatol. 2016 May;68(5): 1060-71. doi: 10.1002/art.39573. Epub 2016 Mar 23.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kavanaugh A, Mease PJ, Gomez-Reino JJ, et al. Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor. Ann Rheum Dis. 2014 Jun;73(6):1020-6. doi: 10.1136/annrheumdis2013-205056. Epub 2014 Mar 4.</mixed-citation><mixed-citation xml:lang="en">Kavanaugh A, Mease PJ, Gomez-Reino JJ, et al. Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor. Ann Rheum Dis. 2014 Jun;73(6):1020-6. doi: 10.1136/annrheumdis2013-205056. Epub 2014 Mar 4.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Корсакова ЮЛ, Денисов ЛН. Эффективность и безопасность нового препарата для лечения псориаза и псориатического артрита – апремиласта. Научно-практическая ревматология. 2016;(54)5:572-8. [Korsakova YuL, Denisov LN. The efficacy and safety of the new drug apremilast for the treatment of psoriasis and psoriatic arthritis. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2016;(54) 5:572-8. (In Russ.)]. doi: 10.14412/1995-4484-2016-572-577</mixed-citation><mixed-citation xml:lang="en">Корсакова ЮЛ, Денисов ЛН. Эффективность и безопасность нового препарата для лечения псориаза и псориатического артрита – апремиласта. Научно-практическая ревматология. 2016;(54)5:572-8. [Korsakova YuL, Denisov LN. The efficacy and safety of the new drug apremilast for the treatment of psoriasis and psoriatic arthritis. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2016;(54) 5:572-8. (In Russ.)]. doi: 10.14412/1995-4484-2016-572-577</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mease P, Hall S, FitzGerald O, et al. Tofacitinib or Adalimumab versus Placebo for Psoriatic Arthritis. N Engl J Med. 2017 Oct 19; 377(16):1537-1550. doi: 10.1056/NEJMoa 1615975.</mixed-citation><mixed-citation xml:lang="en">Mease P, Hall S, FitzGerald O, et al. Tofacitinib or Adalimumab versus Placebo for Psoriatic Arthritis. N Engl J Med. 2017 Oct 19; 377(16):1537-1550. doi: 10.1056/NEJMoa 1615975.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Gladman D, Rigby W, Azevedo VF, et al. Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors. N Engl J Med. 2017 Oct 19;377(16):1525-1536.</mixed-citation><mixed-citation xml:lang="en">Gladman D, Rigby W, Azevedo VF, et al. Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors. N Engl J Med. 2017 Oct 19;377(16):1525-1536.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mease PJ. Biologic therapy for psoriatic arthritis. Rheum Dis Clin North Am. 2015 Nov; 41(4):723-38. doi: 10.1016/j.rdc.2015.07. 010. Epub 2015 Sep 7.</mixed-citation><mixed-citation xml:lang="en">Mease PJ. Biologic therapy for psoriatic arthritis. Rheum Dis Clin North Am. 2015 Nov; 41(4):723-38. doi: 10.1016/j.rdc.2015.07. 010. Epub 2015 Sep 7.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">McInnes IB, Sieper J, Braun J, et al. Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial. Ann Rheum Dis. 2014 Feb;73(2):349-56. doi: 10.1136/annrheumdis2012-202646. Epub 2013 Jan 29.</mixed-citation><mixed-citation xml:lang="en">McInnes IB, Sieper J, Braun J, et al. Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial. Ann Rheum Dis. 2014 Feb;73(2):349-56. doi: 10.1136/annrheumdis2012-202646. Epub 2013 Jan 29.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
