mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2018-2-36-43mrj-823Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSДифференциальный хемореактомный анализ глюкозамина сульфата и нестероидных противовоспалительных препаратов: перспективные синергичные комбинацииDifferential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinationsГромоваО. А.GromovaO. A.

119333, Москва, ул. Вавилова, 40

40, Vavilov St., Moscow 119333

unesco.gromova@gmail.comТоршинИ. Ю.TorshinI. Yu.

119333, Москва, ул. Вавилова, 40

40, Vavilov St., Moscow 119333

ЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

НаумовА. В.NaumovA. V.

129226, Москва, ул. 1-я Леонова, 16

16, First Leonov St., Moscow 129226

РейерИ. А.ReierI. A.

119333, Москва, ул. Вавилова, 40

40, Vavilov St., Moscow 119333

КаратеевА. Е.KarateevA. E.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

Институт фармакоинформатики ФИЦ «Информатика и управление», РАНРоссияInstitute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of SciencesRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationРоссийский геронтологический научно-клинический центрРоссияRussian Gerontology Research and Clinical CenterRussian Federation2018060620181223643Copyright © Громова О.А., Торшин И.Ю., Лила А.М., Наумов А.В., Рейер И.А., Каратеев А.Е., 20182018Громова О.А., Торшин И.Ю., Лила А.М., Наумов А.В., Рейер И.А., Каратеев А.Е.Gromova O.A., Torshin I.Y., Lila A.M., Naumov A.V., Reier I.A., Karateev A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/823

Глюкозамина сульфат (ГС) необходим для регенерации хрящевой ткани, кроме того, он обладает противовоспалительными свойствами, сравнимыми с таковыми нестероидных противовоспалительных препаратов (НПВП). Клинические исследования указывают на синергизм действия ГС и НПВП при остеоартрите (ОА) и при других заболеваниях суставов.

Цель исследования – оценка степени синергизма различных комбинаций ГС и НПВП.

Материал и методы

Материал и методы. Проведен дифференциальный хемореактомный анализ эффектов ГС и семи средств класса НПВП (кеторолак, нимесулид, диклофенак, мелоксикам, декскетопрофен, целекоксиб, эторикоксиб) для определения степени синергизма различных комбинаций ГС и НПВП.

Результаты и обсуждение

Результаты и обсуждение. Показано, что декскетопрофен (и в меньшей степени кеторолак) наиболее эффективно усиливают противовоспалительные свойства ГС. Для использования на практике рекомендован следующий подход: на 1-й неделе лечения для быстрого устранения болевого синдрома назначается наиболее эффективная комбинация – ГС + декскетопрофен (либо ГС + кеторолак), после чего можно использовать комбинацию ГС с НПВП, прием которого в течение более длительного времени сопряжен с минимальными побочными эффектами.

Выводы

Выводы. Результаты исследования показали, что совместное использование ГС и НПВП при патологии суставов является перспективным. 

Glucosamine sulfate (GS) is essential for the regeneration of cartilaginous tissue and, in addition, it has anti-inflammatory properties comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical trials indicate the synergism between GS and NSAIDs in osteoarthritis (OA) and other joint diseases.

Objective

Objective: to estimate the degree of synergism between different combinations of GS and NSAIDs.

Material and methods

Material and methods. A differential chemoreactome analysis was employed to evaluate the effects of GS and seven agents from the class of NSAIDs, such as ketorolac, nimesulide, diclofenac, meloxicam, dexketoprofen, celecoxib, and etoricoxib, for estimating the degree of synergism between different combinations of GS and NSAIDs.

Results and discussion

Results and discussion. Dexketoprofen is shown to enhance most effectively the anti-inflammatory properties of GS as compared to ketorolac that does this to a lesser extent. The drug should be practically used as follows: the most effective combination (GS + dexketoprofen (or GS + ketorolak) is taken at week 1 of treatment for rapid pain elimination; thereafter there may be a combination of GS and NSAIDs, the intake of which is associated with minimal adverse reactions for a longer time.

Conclusion

Conclusion. The investigation has shown that the coadministration of GS and NSAIDs is promising in treating joint diseases. 

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The authors declare that there are no conflicts of interest present.