mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2018-3-40-52mrj-841Research ArticleОБЗОРЫREVIEWSПрепараты гиалуроновой кислоты в лечении остеоартрита: все ли нам ясно?Hyaluronic acid preparations in the treatment of osteoarthritis: is it clear to us?КаратеевА. Е.KarateevA. E.

Андрей Евгеньевич Каратеев

115522, Москва, Каширское шоссе, 34А

Andrey Evgenyevich Karateev

34A, Kashirskoe Shosse, Moscow 115522

aekarat@yandex.ruПогожеваЕ. Ю.PogozhevaЕ. Yu.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

АмирджановаВ. Н.AmirdzhanovaV. N.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФилатоваЕ. С.FilatovaЕ. S.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation2018150920181234052Copyright © Каратеев А.Е., Погожева Е.Ю., Амирджанова В.Н., Филатова Е.С., 20182018Каратеев А.Е., Погожева Е.Ю., Амирджанова В.Н., Филатова Е.С.Karateev A.E., Pogozheva Е.Y., Amirdzhanova V.N., Filatova Е.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/841

Остеоартрит (ОА) – прогрессирующее заболевание суставов, вызывающее стойкую боль, ограничение функции суставов, потерю трудоспособности и социальной активности. Одним из популярных методов лечения ОА являются внутрисуставные (в/с) инъекции препаратов гиалуроновой кислоты (ГлК). Эта методика вошла в клиническую практику в начале 80-х годов прошлого века и получила повсеместное распространение. До настоящего времени не существует единого мнения о терапевтической ценности ГлК. Многие исследования подтверждают эффективность ГлК, причем в качестве не только симптоматического, но и структурномодифицирующего средства. Вместе в тем в некоторых работах действие ГлК было равным эффекту плацебо (в/с введение физиологического раствора) или лишь ненамного его превосходило. В обзоре рассмотрены механизм действия и сравнительная эффективность различных препаратов ГлК (низкои высокомолекулярной), а также безопасность их использования в реальной клинической практике.

Osteoarthritis (OA) is a progressive joint disease that causes persistent pain, limited joint function, disability, and loss of social activity. One of the most popular OA treatment options is intra-articular (I/A) hyaluronic acid (HA) injections. This procedure was introduced into clinical practice in the early 1980s and is used universally. To date, there is no consensus on the therapeutic value of HA. Many investigations confirm that HA is effective as not only a symptomatic agent, but also a structure-modifying one. Some works also show that the effect of HA is equal or only slightly superior to that of placebo (I/A saline injection). The review describes the mechanism of action and comparative efficacy of various (lowand high-molecular weight) HA preparations, as well as the safety of their use in real clinical practice.

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The authors declare that there are no conflicts of interest present.