mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2018-3-70-75mrj-844Research ArticleОБЗОРЫREVIEWSАктуальная стратегия лечения подагрического артритаThe current treatment strategy for gouty arthritisПетроваМ. С.PetrovaM. S.

Марианна Семеновна Петрова

191015, Санкт-Петербург, ул. Кирочная, 41

Marianna Semenovna Petrova

41, Kirochnaya St., Saint Petersburg 191015

podagra@bk.ruМусийчукМ. М.MusiychukМ. M.

191015, Санкт-Петербург, ул. Кирочная, 41

41, Kirochnaya St., Saint Petersburg 191015

МазуровВ. И.MazurovV. I.

191015, Санкт-Петербург, ул. Кирочная, 41

41, Kirochnaya St., Saint Petersburg 191015

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияI.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaRussian Federation2018160920181237075Copyright © Петрова М.С., Мусийчук М.М., Мазуров В.И., 20182018Петрова М.С., Мусийчук М.М., Мазуров В.И.Petrova M.S., Musiychuk М.M., Mazurov V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/844

Фебуксостат – непуриновый селективный ингибитор изоформ ксантиноксидоредуктазы (КОР), действие которого направлено на снижение уровня мочевой кислоты в сыворотке крови. Фебуксостат – более мощный ингибитор КОР, чем аллопуринол, что подтверждается достижением целевого уровня МК при лечении фебуксостатом чаще, чем при приеме аллопуринола, особенно у пациентов с высокой концентрацией уратов в сыворотке крови. Фармакокинетические свойства фебуксостата не зависят от почечного клиренса, что отличает его от аллопуринола и может быть преимуществом для пациентов с хроническими заболеваниями почек. В ряде исследований проводится дальнейшая оценка безопасности фебуксостата для сердечно-сосудистой системы и его возможного позитивного действия на сохранение функции почек. Важным является и то, что у пожилых пациентов не требуется коррекции дозы фебуксоcтата.

Febuxostat is a non-purine selective inhibitor of isoforms of xanthine oxidoreductase (XOR), the effect of which is aimed at lowering the level of serum uric acid (UA). Febuxostat is a more potent inhibitor of XOR than allopurinol, as confirmed by that target UA levels have been achieved more frequently with febuxostat than with allopurinol, particularly in patients with high serum urate concentrations. The pharmacokinetic properties of febuxostat are not dependent on renal clearance, which distinguishes it from allopurinol and may benefit patients with chronic kidney disease. A number of studies are being conducted to further evaluate the cardiovascular safety of febuxostat and its possible positive effects in preserving renal function. Of importance is the fact that febuxostat does not require dose adjustment in elderly patients.

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The authors declare that there are no conflicts of interest present.