mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2018-3-120-123mrj-853Research ArticleФАРМАКОЛОГИЧЕСКИЙ НАДЗОРPHARMACOVIGILANCEПроблема лабораторного мониторинга при терапии базисными противовоспалительными и генно-инженерными биологическими препаратами у больных ревматоидным артритомThe problem of laboratory monitoring in therapy with disease-modifying antirheumatic drugs and biological agents in patients with rheumatoid arthritisМуравьевЮ. В.MuravyevYu. V.

Юрий Владимирович Муравьев

115522, Москва, Каширское шоссе, 34А

Yuri Vladimirovich Muravyev

34A, Kashirskoe Shosse, Moscow 115522

murawyu@mail.ruМуравьеваЛ. А.MuravyevaL. A.

Центральное поликлиническое отделение

141400, Московская область, Химки, ул. Чкалова, 2/21

Central Polyclinic Department

2/21, Chkalov St., Khimki, Moscow Region 141400

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationМБУЗ «Химкинская центральная клиническая больница»РоссияKhimki Central Clinical HospitalRussian Federation201816092018123120123Copyright © Муравьев Ю.В., Муравьева Л.А., 20182018Муравьев Ю.В., Муравьева Л.А.Muravyev Y.V., Muravyeva L.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/853

Обсуждается проблема лабораторного мониторинга при терапии базисными противовоспалительными и генно-инженерными биологическими препаратами у больных ревматоидным артритом (РА). В связи с риском возникновения неблагоприятных реакций, в частности сердечно-сосудистых заболеваний, гепатотоксичности, гематологических нарушений, ухудшения функции почек, инфекций, кровотечений, обусловленных применением БПВП и ГИБП, необходимы рекомендации, касающиеся перечня тестов для лабораторного контроля в период использования такой терапии и частоты их выполнения у больных РА.

The paper discusses the problem of laboratory monitoring in therapy with disease-modifying antirheumatic drugs (DMARDs) and biological agents (BAs) in patients with rheumatoid arthritis (RA). Due to the risk of adverse reactions, in particular to that of cardiovascular diseases, hepatotoxicity, hematological disorders, deterioration of renal function, infections, and bleeding caused by the use of DMARDs and BAs, recommendations are needed to have a list of tests for laboratory monitoring during this therapy and the frequency of their implementation in patients with RA.

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The authors declare that there are no conflicts of interest present.