References

mrj

Современная ревматология

Modern Rheumatology Journal

1996-70122310-158X

IMA-PRESS, LLC

10.14412/1996-7012-2018-4-9-15

mrj-856

Research Article

ОБЗОРЫ

REVIEWS

Особенности Т- регуляторных клеток у больных системной красной волчанкой

Specific features of regulatory T cells in patients with systemic lupus erythematosus

Торгашина

А. В.

Torgashina

A. V.

Анна Васильевна Торгашина.

115522, Москва, Каширское шоссе, 34А.

anna.torgashina@gmail.com

Соловьев

С. К.

Solovyev

S. К.

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».РоссияV.A. Nasonova Research Institute of Rheumatology.Russian Federation

2018

05122018

124915

2018

Торгашина А.В., Соловьев С.К.

Torgashina A.V., Solovyev S.К.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://mrj.ima-press.net/mrj/article/view/856

Т-регуляторные (Т-рег) клетки – субпопуляция CD4+ лимфоцитов, поддерживающая аутотолерантность организма путем подавления активности аутореактивных лимфоцитов. Существует гипотеза, что дефекты функций или снижение количества Т-рег-клеток лежат в основе патогенеза ряда аутоиммунных заболеваний. В статье рассмотрены основные особенности фенотипа Т-рег-клеток. Обсуждаются количество Т-рег-клеток как в периферической крови, так и в пораженных органах при системной красной волчанке, а также динамика уровня и функциональных способностей различных субпопуляций Т-рег-клеток на фоне иммуносупрессивной терапии. Кроме того, представлены различные подходы к использованию Т-рег-лимфоцитов в терапии аутоиммунных заболеваний.

Regulatory T cells (Tregs) is a CD4+ lymphocyte subpopulation that maintains autotolerance by suppressing the activity of autoreactive lymphocytes. There is a hypothesis that functional defects or a smaller number of Tregs underlie the pathogenesis of a number of autoimmune diseases. The paper considers the main features of the phenotype of Tregs. It discusses the number of Tregs in both peripheral blood and affected organs in systemic lupus erythematosus, as well as the time course of changes in the level and functional abilities of different subpopulations of Tregs during immunosuppressive therapy. In addition, the paper presents various approaches to using Treg lymphocytes in the therapy of autoimmune diseases.

Т-регуляторные клеткисистемная красная волчанкацитокины

regulatory T cellssystemic lupus erythematosuscytokines

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The authors declare that there are no conflicts of interest present.