<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2019-1-71-79</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-889</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Беременность при анкилозирующем спондилите: взгляд пациентки и врача</article-title><trans-title-group xml:lang="en"><trans-title>Pregnancy in ankylosing spondylitis: the view of a female patient and a physician</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гандалоева</surname><given-names>З. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gandaloeva</surname><given-names>Z. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зулейхан Микаиловна Гандалоева</p><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>Zuleikhan Mikailovna Gandaloeva</p><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><email xlink:type="simple">gzm92@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кричевская</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krichevskaya</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глухова</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Glukhova</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дубинина</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dubinina</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>26</day><month>03</month><year>2019</year></pub-date><volume>13</volume><issue>1</issue><fpage>71</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гандалоева З.М., Кричевская О.А., Глухова С.И., Дубинина Т.В., Лила А.М., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Гандалоева З.М., Кричевская О.А., Глухова С.И., Дубинина Т.В., Лила А.М.</copyright-holder><copyright-holder xml:lang="en">Gandaloeva Z.M., Krichevskaya O.A., Glukhova S.I., Dubinina T.V., Lila A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/889">https://mrj.ima-press.net/mrj/article/view/889</self-uri><abstract><p>Цель исследования — изучение влияния диагноза анкилозирующего спондилита (АС) на планирование пациентками беременности, их отношения к применению лекарственных средств (ЛС) при подготовке и во время гестации, а также оценка компетентности врачей в вопросах беременности при АС.</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. Представлены данные трех исследований, основанных на анкетировании пациенток с АС и ревматологов. Результаты и обсуждение. Анкетирование выявило уменьшение числа беременностей на одну женщину после дебюта АС. Узнав о диагнозе АС, 70% пациенток сообщили о пересмотре планов на материнство, при этом большинство женщин (80%) ответили, что решатся на беременность, однако постоянно будут испытывать дискомфорт и чувство страха за свое здоровье и здоровье будущего ребенка. Не были настроены на беременность в связи с развитием у них АС 13,9% респонденток независимо от отсутствия или наличия детей, рожденных в здоровый период жизни. Только 50% пациенток обсуждали вопросы планирования беременности с ревматологом, при этом треть из них не получили необходимой информации. Лишь четверть больных допускали продолжение терапии АС при подготовке к зачатию и во время гестации.</p><p>В целом российские ревматологи имеют достаточный объем знаний об исходах беременности при АС, в частности о факторах, влияющих на ее благоприятный исход, основах диспансерного наблюдения за беременными. В то же время 18% ревматологов ожидают усиления активности АС при гестации, более 2/3 считают наличие сакроилиита показанием к оперативным родам, а 30% готовы отменить лекарственные средства (ЛС), разрешенные к применению до беременности.</p></sec><sec><title>Выводы</title><p>Выводы. Дефицит информации, касающейся планирования и течения беременности при АС, риска обострения заболевания и безопасности терапии при гестации, отмечается как у больных АС, так и у ревматологов. Необходимо проведение образовательных мероприятий для врачей и специализированных школ для пациенток детородного возраста и членов их семей, посвященных проблеме беременности при АС.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to study the impact of the diagnosis of ankylosing spondylitis (AS) on the planning of pregnancy by patients and their attitude towards the use of drugs during gestation and to assess the competency of physicians in the issues relating to pregnancy in AS.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. The data of three studies based on the questionnaire surveys of female AS patients and rheumatologists.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. The questionnaire survey revealed a decline in the number of pregnancies per woman after the onset of AS. Having learned about their diagnosis, 70% of patients reported a change in their maternity plans; however, most (80%) women said that they were still going to become pregnant, but they would constantly feel discomfort and fear for their own health and the health of their future child. Pregnancy was rejected due to AS development by 13.9% of patients, regardless of the presence or absence of children born in the healthy period of their life. Only 50% of women discussed the issues relating to pregnancy with a rheumatologist, and one third of them did not obtain the necessary information. Only one fourth of patients were ready to continue treatment for AS in the period of preparation for conception and during gestation.</p><p>On the whole, Russian rheumatologists have enough knowledge about pregnancy outcomes in AS, and, in particular, about the factors which may influence the favorable outcome and about the fundamentals of follow-up for pregnant women. At the same time, 18% of rheumatologists expect increased AS activity during gestation, more than two thirds consider sacroiliitis to be an indication for surgical delivery, and 30% are ready to discontinue the drugs which are permitted for use before pregnancy.</p></sec><sec><title>Conclusion</title><p>Conclusion. Lack of information about the planning and course of pregnancy in AS, the risk of disease exacerbation and the safety of therapy during gestation is noted in both patients and rheumatologists. It is necessary to implement educational measures on the problem of pregnancy in AS for rheumatologists and women of fertile age and their family members.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>анкилозирующий спондилит</kwd><kwd>беременность</kwd><kwd>активность заболевания</kwd><kwd>анкетирование</kwd><kwd>лекарственная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ankylosing spondylitis</kwd><kwd>pregnancy</kwd><kwd>disease activity</kwd><kwd>questionnaire survey</kwd><kwd>drug therapy</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Межрегиональная общественная благотворительная организация инвалидов «Общество взаимопомощи при болезни Бехтерева»,президентА.В. Ситало; профессор П.А. Шестерна, к.м.н. М.А. Королеву; ЮСБ Фарма, ООО</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кричевская ОА, Гандалоева ЗМ, Дубинина ТВ. Анкилозирующий спондилит и беременность: современный взгляд на проблему. Современная ревматология. 2018;12(3):19-28. doi: 10.14412/1996-7012-2018-3-19-28</mixed-citation><mixed-citation xml:lang="en">Krichevskaya OA, Gandaloeva ZM, Dubinina TV. Ankylosing spondylitis and pregnancy: a current view on the problem. Sovremennaya revmatologiya = Modern Rheumatology Journal. 2018;12(3): 19-28. (In Russ.). doi: 10.14412/1996-7012-2018-3-19-28</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гандалоева ЗМ, Кричевская ОА, Дубинина ТВ и др. Анкилозирующий спондилит и беременность: данные пилотного исследования, основанного на анкетировании пациенток. Научно-практическая ревматология. 2018;56(2):208-14. doi: 10.14412/1995-4484-2018-208-214</mixed-citation><mixed-citation xml:lang="en">Gandaloeva ZM, Krichevskaya OA, Dubinina TV, et al. Ankylosing spondylitis and pregnancy: data from a pilot study based on a questionnaire survey of patients. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2018;56(2):208-14. (In Russ.). doi: 10.14412/1995-4484-2018-208-214</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Кошелева НМ. Планирование беременности и наблюдение за беременными с ревматическими заболеваниями. В кн.: Насонов ЕЛ, редактор. Российские клинические рекомендации. Ревматология. Москва: ГЭОТАР-Медиа; 2017. С. 380-9.</mixed-citation><mixed-citation xml:lang="en">Kosheleva NM. Pregnancy planning and monitoring of pregnant women with rheumatic diseases. In: Nasonov EL, editor. Rossiiskie klinicheskie rekomendatsii. Revmatologiya [Russiam clinical guidelines. Rheumatology]. Moscow: GEOTAR-Media; 2017. P. 380-9.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gotestam Skorpen C, Hoeltzenbein M, Tincani A, et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016 May;75(5): 795-810. doi: 10.1136/annrheumdis-2015-208840. Epub 2016 Feb 17.</mixed-citation><mixed-citation xml:lang="en">Gotestam Skorpen C, Hoeltzenbein M, Tincani A, et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016 May;75(5): 795-810. doi: 10.1136/annrheumdis-2015-208840. Epub 2016 Feb 17.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mills B, Dao KH, Tecson K, et al. Perceptions and Outcomes of Pregnancy and Lactation in Patients with Rheumatic Diseases [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/perceptions-and-outcomes-of-preg-nancy-and-lactation-in-patients-with-rheu-matic-diseases/. Accessed March 2, 2019.</mixed-citation><mixed-citation xml:lang="en">Mills B, Dao KH, Tecson K, et al. Perceptions and Outcomes of Pregnancy and Lactation in Patients with Rheumatic Diseases [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/perceptions-and-outcomes-of-preg-nancy-and-lactation-in-patients-with-rheu-matic-diseases/. Accessed March 2, 2019.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.demoscope.ru/weekly/2014/0611/reprod02.php</mixed-citation><mixed-citation xml:lang="en">http://www.demoscope.ru/weekly/2014/0611/reprod02.php</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Haroun T, Eudy AM, Jayasundara M, et al. Tough Choices: Understanding the medication decision-making process for women with inflammatory arthritis during pregnancy and lactation. Presented at: ACR/ARHP Annual Meeting; November 3-8, 2017; San Diego, CA. Abstract 1298</mixed-citation><mixed-citation xml:lang="en">Haroun T, Eudy AM, Jayasundara M, et al. Tough Choices: Understanding the medication decision-making process for women with inflammatory arthritis during pregnancy and lactation. Presented at: ACR/ARHP Annual Meeting; November 3-8, 2017; San Diego, CA. Abstract 1298</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Panchal S, Khare M, Moorthy A, Samanta A. Catch me if you can: a national survey of rheumatologists and obstetricians on the use of DMARDs during pregnancy. RheumatolInt. 2013 Feb;33(2):347-53. https://doi.org/10.1007/s00296-012-2418-0. Epub 2012 Mar 27.</mixed-citation><mixed-citation xml:lang="en">Panchal S, Khare M, Moorthy A, Samanta A. Catch me if you can: a national survey of rheumatologists and obstetricians on the use of DMARDs during pregnancy. RheumatolInt. 2013 Feb;33(2):347-53. https://doi.org/10.1007/s00296-012-2418-0. Epub 2012 Mar 27.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Фесенко ЭВ, Коновалов ЯС, Аксёнов ДВ и др. Современные проблемы обеспечения приверженности пациентов пожилого возраста с сердечно-сосудистой патологией к фармакотерапии. Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация, 2011;22(16/1):95-9.</mixed-citation><mixed-citation xml:lang="en">Fesenko EV, Konovalov YaS, Aksenov DV, et al. Modern problems of ensuring adherence of elderly patients with cardiovascular pathology to pharmacotherapy. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Meditsina. Farmatsiya, 2011;22(16/1):95-9. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005 Aug 4; 353(5):487-97.</mixed-citation><mixed-citation xml:lang="en">Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005 Aug 4; 353(5):487-97.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Лукина ЮВ, Кутишенко НП, Марцевич СЮ. Приверженность лечению: современный взгляд на знакомую проблему. Кардиоваскулярная терапия и профилактика. 2017;16(1):91—5. doi: 10.15829/1728-8800-2017-1-91-95</mixed-citation><mixed-citation xml:lang="en">Lukina YuV, Kutishenko NP, Martsevich SYu. Treatment adherence: a modern view of familiar problems. Kardiovaskulyarnaya terapiya i profilaktika. 2017;16(1):91—5. (In Russ.). doi: 10.15829/1728-8800-2017-1-91-95</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Vangeli E, Bakhshi S, Baker A, et al. A systematic review of factors associated with non-adherence to treatment for immune-mediated inflammatory diseases. Adv Ther. 2015 Nov;32(11):983-1028. doi: 10.1007/s12325-015-0256-7. Epub 2015 Nov 7.</mixed-citation><mixed-citation xml:lang="en">Vangeli E, Bakhshi S, Baker A, et al. A systematic review of factors associated with non-adherence to treatment for immune-mediated inflammatory diseases. Adv Ther. 2015 Nov;32(11):983-1028. doi: 10.1007/s12325-015-0256-7. Epub 2015 Nov 7.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Arturi P, Schneeberger EE, Sommerfleck F, et al. Adherence to treatment in patients with ankylosing spondylitis. Clin Rheumatol. 2013 Jul;32(7):1007-1015. doi: 10.1007/s10067-013-2221-7.</mixed-citation><mixed-citation xml:lang="en">Arturi P, Schneeberger EE, Sommerfleck F, et al. Adherence to treatment in patients with ankylosing spondylitis. Clin Rheumatol. 2013 Jul;32(7):1007-1015. doi: 10.1007/s10067-013-2221-7.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Michetti P, Weinman J, Mrowietz U, et al. Impact of treatment-related beliefs on medication adherence in immune-mediated in?ammatory diseases: results of the global ALIGN Study. Adv Ther. 2015 Nov;32(11): 983-1028. doi: 10.1007/s12325-015-0256-7. Epub 2015 Nov 7.</mixed-citation><mixed-citation xml:lang="en">Michetti P, Weinman J, Mrowietz U, et al. Impact of treatment-related beliefs on medication adherence in immune-mediated in?ammatory diseases: results of the global ALIGN Study. Adv Ther. 2015 Nov;32(11): 983-1028. doi: 10.1007/s12325-015-0256-7. Epub 2015 Nov 7.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Desai RJ, Huybrechts KF, Bateman BT, et al. Patterns and secular trends in use of immunomodulatory agents during pregnancy in women with rheumatologic conditions. Arthritis Rheumatol. 2016 May;68(5):1183-9. doi: 10.1002/art.39521.</mixed-citation><mixed-citation xml:lang="en">Desai RJ, Huybrechts KF, Bateman BT, et al. Patterns and secular trends in use of immunomodulatory agents during pregnancy in women with rheumatologic conditions. Arthritis Rheumatol. 2016 May;68(5):1183-9. doi: 10.1002/art.39521.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Van den Brandt S, Zbinden A, Baeten D, et al. Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients. Arthritis Res Ther. 2017 Mar 20;19(1):64. doi: 10.1186/s13075-017-1269-1.</mixed-citation><mixed-citation xml:lang="en">Van den Brandt S, Zbinden A, Baeten D, et al. Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients. Arthritis Res Ther. 2017 Mar 20;19(1):64. doi: 10.1186/s13075-017-1269-1.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
