mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2019-2-105-111mrj-918Research ArticleОБЗОРЫREVIEWSАнализ распространенности и факторов риска развития остеоартрита в популяцииAnalysis of the prevalence and risk factors of osteoarthritis in a populationПортянниковаО. О.PortyannikovaO. O.

672000, Чита, ул. Горького, 39а

39a, Gorky St., Chita 672000

Olesya13@bk.ruЦвингерС. М.TsvingerS. M.

672000, Чита, ул. Горького, 39а

39a, Gorky St., Chita 672000

ГоворинА. В.GovorinA. V.

672000, Чита, ул. Горького, 39а

39a, Gorky St., Chita 672000

РомановаЕ. Н.RomanovaE. N.

672000, Чита, ул. Горького, 39а

39a, Gorky St., Chita 672000

ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава РоссииРоссияChita State Medical Academy, Ministry of Health of RussiaRussian Federation201920052019132105111Copyright © Портянникова О.О., Цвингер С.М., Говорин А.В., Романова Е.Н., 20192019Портянникова О.О., Цвингер С.М., Говорин А.В., Романова Е.Н.Portyannikova O.O., Tsvinger S.M., Govorin A.V., Romanova E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/918

В обзоре отражены данные крупномасштабных зарубежных и российских исследований, посвященных эпидемиологии остеоартрита (ОА). Рассматривается роль модифицируемых и немодифицируемых факторов риска развития ОА, таких как возраст, пол, гормональный статус, ожирение и др. Приводятся данные о наследственной предрасположенности к ОА и наличии врожденных аномалий, способствующих формированию структурных изменений сустава. Анализируются сведения о воздействии расовых и этнических факторов на развитие и прогрессирование ОА. Освещается роль метаболических нарушений в патогенезе этого заболевания. Обобщаются данные о связи ОА с профессиональной деятельностью пациентов.

The review contains data from large-scale foreign and Russian studies of the epidemiology of osteoarthritis (OA). It considers the role of modifiable and non-modifiable risk factors for OA, such as age, sex, hormonal status, obesity, etc. There are data on genetic susceptibility to OA and on congenital anomalies that contribute to joint structural changes. Data on the impact of racial and ethnic factors on the development and progression of OA are analyzed. The role of metabolic disorders in the pathogenesis of this disease is highlighted. Data on the relationship of OA to patients' professional activities are summarized.

остеоартритфакторы рискаэпидемиологиязарубежные исследованияostheoarthritisrisk factorsepidemiologyforeign studiesReferencesПротопопова РН, Эрдес Ш, Кривошапкин ВГ. Эпидемиологическое исследование распространенности остеоартроза среди коренных сельских жителей республики Саха (Якутия). Сообщение 2. Научно-практическая ревматология. 2000;38(3):28-34. doi: 10.14412/1995-4484-2000-1445Protopopova RN, Erdes Sh, Krivoshapkin VG. Epidemiological study of the prevalence of osteoarthritis among indigenous rural residents of the Republic of Sakha (Yakutia). Message 2. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2000;38(3):28-34. (In Russ.). doi: 10.14412/1995-4484-2000-1445Насонов ЕЛ, редактор. Российские клинические рекомендации. Ревматология. Москва: ГЭОТАР-Медиа; 2017. С. 42-50.Nasonov EL, editor. Rossiiskie klinicheskie rekomendatsii. Revmatologiya [Russian clinical guidelines. Rheumatology]. Moscow: GEOTAR-Media; 2017. P. 42-50..Cooper C, Dennison E, Edwards M, et al. Epidemiology of ostheoarthritis. Medicographia. 2013;35:145-51.Cooper C, Dennison E, Edwards M, et al. Epidemiology of ostheoarthritis. Medicographia. 2013;35:145-51.Leung YY, Pua YH, Thumbo J. A perspective on ostheoathritis research in Singapore. Proceeding of Singapore healthcare. 2013; 22(1):31-9.Leung YY, Pua YH, Thumbo J. A perspective on ostheoathritis research in Singapore. Proceeding of Singapore healthcare. 2013; 22(1):31-9.Murray CJ, Lopez AD, Mathers CD, et al. Global burden of disease and risk factors. Washington: World Bank, Oxford University Press; 2006. 475 p.Murray CJ, Lopez AD, Mathers CD, et al. Global burden of disease and risk factors. Washington: World Bank, Oxford University Press; 2006. 475 p.Andrianakos AA, Kontelis LK, Karamitsos DG, et al. Prevalence of symptomatic knee, hand and hip ostheoarthritis in Greece. The ESORDIG study. J Rheumatol. 2006 Dec;33(12):2507-13.Andrianakos AA, Kontelis LK, Karamitsos DG, et al. Prevalence of symptomatic knee, hand and hip ostheoarthritis in Greece. The ESORDIG study. J Rheumatol. 2006 Dec;33(12):2507-13.Kopec JA, Rahman MM, Sayre EC, et al. Trends in physician-diagnosed osteoarthritis incidence in an administrative database in British Columbia, Canada, 1996-1997 through 2003-2004. Arthritis Rheum. 2008 Jul 15;59(7):929-34. doi: 10.1002/art.23827.Kopec JA, Rahman MM, Sayre EC, et al. Trends in physician-diagnosed osteoarthritis incidence in an administrative database in British Columbia, Canada, 1996-1997 through 2003-2004. Arthritis Rheum. 2008 Jul 15;59(7):929-34. doi: 10.1002/art.23827.Nguyen US, Zhang Y, Zhu Y, et al. Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann Intern Med. 2011 Dec 6;155(11): 725-32. doi: 10.7326/0003-4819-155-11-201112060-00004.Nguyen US, Zhang Y, Zhu Y, et al. Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann Intern Med. 2011 Dec 6;155(11): 725-32. doi: 10.7326/0003-4819-155-11-201112060-00004.March LM, Bagga H. Epidemiology of ostheoarthritis in Australia. Med J Aust. 2004 Mar 1;180(5 Suppl):S6-10.March LM, Bagga H. Epidemiology of ostheoarthritis in Australia. Med J Aust. 2004 Mar 1;180(5 Suppl):S6-10.Pal CP, Singh P, Chaturvedi S, et al. Epidemiology of knee ostheoarthritis in India and related factors. Indian J Orthop. 2016 Sep; 50(5):518-522.Pal CP, Singh P, Chaturvedi S, et al. Epidemiology of knee ostheoarthritis in India and related factors. Indian J Orthop. 2016 Sep; 50(5):518-522.Фоломеева ОМ, Эрдес ШФ. Распространенность и социальная значимость ревматических заболеваний в Российской Федерации. Доктор (ревматология). 2007;(10):3–12.Folomeeva OM, Erdes ShF. Prevalence and social significance of rheumatic diseases in the Russian Federation. Doktor (revmatologiya). 2007;(10): 3–12. (In Russ.).Беневоленская ММ, Бржезовский ЛИ. Эпидемиология ревматических болезней. Москва: Медицина; 1988. 115 с.Benevolenskaya MM, Brzhezovskii LI. Epidemiologiya revmaticheskikh boleznei [Epidemiology of rheumatic diseases]. Moscow: Meditsina; 1988. 115 p..Галушко ЕА, Эрдес ШФ, Алексеева ЛИ. Остеоартроз в амбулаторной практике. Современная ревматология. 2012;6(4): 66-70. doi: 10.14412/1996-7012-2012-766Galushko EA, Erdes ShF, Alekseeva LI. Osteoarthrosis in outpatient practice. Sovremennaya revmatologiya = Modern Rheumatology Journal. 2012;6(4): 66-70. (In Russ.). doi: 10.14412/1996-7012-2012-766Меньшикова ЛВ. Остеоартроз (диагностика, лечение, реабилитация): Пособие для врачей. Иркутск: РИО ИГИУВ; 2007. 40 c.Men'shikova LV. Osteoartroz (diagnostika, lechenie, reabilitatsiya): Posobie dlya vrachei [Osteoarthritis (diagnosis, treatment, rehabilitation): Manual for doctors]. Irkutsk: RIO IGIUV; 2007. 40 p..Данчинова АМ, Батудаева ТИ, Меньшикова ЛВ. Эпидемиология остеоартроза в республике Бурятия. Сибирский медицинский журнал. 2012;(6):112-4.Danchinova AM, Batudaeva TI, Men'shikova LV. Epidemiology of osteoarthritis in the Republic of Buryatia. Sibirskii meditsinskii zhurnal. 2012;(6):112-4. (In Russ.).Балабанова РМ, Дубинина ТВ, Демина АБ и др. Заболеваемость болезнями костно-мышечной системы в Российской Федерации за 2015-2016 гг. Научно-практическая ревматология. 2018;56(1):15-21. doi: 10.14412/1995-4484-2018-15-21Balabanova RM, Dubinina TV, Demina AB, et al. The incidence of musculoskeletal diseases in the Russian Federation over 2015–2016. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2018;56(1):15-21. (In Russ.). doi: 10.14412/1995-4484-2018-15-21De Koning EJ, Timmermans EJ, van Schoor NM, et al. Within - Person pain variability and mental health in older adults with osteoarthritis: an analysis across 6 european cohorts. J Pain. 2018 Jun;19(6): 690-698. doi: 10.1016/j.jpain.2018.02.006. Epub 2018 Mar 2.De Koning EJ, Timmermans EJ, van Schoor NM, et al. Within - Person pain variability and mental health in older adults with osteoarthritis: an analysis across 6 european cohorts. J Pain. 2018 Jun;19(6): 690-698. doi: 10.1016/j.jpain.2018.02.006. Epub 2018 Mar 2.Kim C, Linsenmeyer KD, Vlad SC, et al. Prevalence of radiographic and symptomatic hip osteoarthritis in an urban United States community: the Framingham osteoarthritis study. Arthritis Rheumatol. 2014 Nov;66(11): 3013-7. doi: 10.1002/art.38795.Kim C, Linsenmeyer KD, Vlad SC, et al. Prevalence of radiographic and symptomatic hip osteoarthritis in an urban United States community: the Framingham osteoarthritis study. Arthritis Rheumatol. 2014 Nov;66(11): 3013-7. doi: 10.1002/art.38795.Lanyon P, O'Reilly S, Jones A, et al. Radiographic assessment of symptomatic knee osteoarthritis in the community: definitions and normal joint space. Ann Rheum Dis. 1998 Oct;57(10):595-601.Lanyon P, O'Reilly S, Jones A, et al. Radiographic assessment of symptomatic knee osteoarthritis in the community: definitions and normal joint space. Ann Rheum Dis. 1998 Oct;57(10):595-601.Cho HJ, Gn KK, Kang JY, et al. Epidemiological characteristics of patellofemoral osteoarthritis in elderly Koreans and its symptomatic contribution in knee osteoarthritis. Knee. 2016 Jan;23(1): 29-34. doi: 10.1016/j.knee.2015.09.003. Epub 2015 Dec 31.Cho HJ, Gn KK, Kang JY, et al. Epidemiological characteristics of patellofemoral osteoarthritis in elderly Koreans and its symptomatic contribution in knee osteoarthritis. Knee. 2016 Jan;23(1): 29-34. doi: 10.1016/j.knee.2015.09.003. Epub 2015 Dec 31.Hunter D, Arden N, Conaghan P, et al. Definition of osteoarthritis on MRI: results of a Delphi exercise. Osteoarthritis Cartilage. 2011 Aug;19(8):963-9. doi: 10.1016/j.joca. 2011.04.017. Epub 2011 May 12.Hunter D, Arden N, Conaghan P, et al. Definition of osteoarthritis on MRI: results of a Delphi exercise. Osteoarthritis Cartilage. 2011 Aug;19(8):963-9. doi: 10.1016/j.joca. 2011.04.017. Epub 2011 May 12.Laires P, Canhao H, Rodrigues AM, et al. The impact of osteoarthritis on early exit from work: results from a population-based study. BMC Public Health. 2018 Apr 11;18(1): 472. doi: 10.1186/s12889-018-5381-1.Laires P, Canhao H, Rodrigues AM, et al. The impact of osteoarthritis on early exit from work: results from a population-based study. BMC Public Health. 2018 Apr 11;18(1): 472. doi: 10.1186/s12889-018-5381-1.Arden N, Nevitt M. Osteoarthritis: Epidemiology. Best Pract Res Clin Rheumatol. 2006 Feb;20(1):3-25.Arden N, Nevitt M. Osteoarthritis: Epidemiology. Best Pract Res Clin Rheumatol. 2006 Feb;20(1):3-25.Felson D, Lawence R, Dieppe P, et al. Osteoarthritis: new insights. Part 1: The disease and its risk factors. Ann Intern Med. 2000 Oct 17;133(8):635-46.Felson D, Lawence R, Dieppe P, et al. Osteoarthritis: new insights. Part 1: The disease and its risk factors. Ann Intern Med. 2000 Oct 17;133(8):635-46.Zhang Y, Jordan J. Epidemiology of ostheoarthritis. Clin Geriatr Med. 2010 Aug; 26(3):355-69. doi: 10.1016/j.cger.2010.03.001.Zhang Y, Jordan J. Epidemiology of ostheoarthritis. Clin Geriatr Med. 2010 Aug; 26(3):355-69. doi: 10.1016/j.cger.2010.03.001.Van Saase JL, van Romunde LK, Cats A, et al. Epidemiology os osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations. Ann Rheum Dis. 1989 Apr;48(4):271-80.Van Saase JL, van Romunde LK, Cats A, et al. Epidemiology os osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations. Ann Rheum Dis. 1989 Apr;48(4):271-80.Oliveria S, Felson D, Reed J, et al. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum. 1995 Aug;38(8):1134-41.Oliveria S, Felson D, Reed J, et al. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum. 1995 Aug;38(8):1134-41.Dougados M, Gueguen A, Nguyen M, et al. Radiological progression of hip osteoarthritis: definition, risk factors and correlations with clinical status. Ann Rheum Dis. 1996 Jun;55(6):356-62.Dougados M, Gueguen A, Nguyen M, et al. Radiological progression of hip osteoarthritis: definition, risk factors and correlations with clinical status. Ann Rheum Dis. 1996 Jun;55(6):356-62.Loeser R, Shakoor N. Aging or osteoarthritis: which is the problem? Rheum Dis Clin North Am. 2003 Nov;29(4):653-73.Loeser R, Shakoor N. Aging or osteoarthritis: which is the problem? Rheum Dis Clin North Am. 2003 Nov;29(4):653-73.Culliford D, Maskell J, Kiran A, et al. The lifetime risk of total hip and knee arthroplasty: results from the UK General Practice Research Database. Osteoarthritis Cartilage. 2012 Jun;20(6):519-24. doi: 10.1016/j.joca. 2012.02.636. Epub 2012 Mar 3.Culliford D, Maskell J, Kiran A, et al. The lifetime risk of total hip and knee arthroplasty: results from the UK General Practice Research Database. Osteoarthritis Cartilage. 2012 Jun;20(6):519-24. doi: 10.1016/j.joca. 2012.02.636. Epub 2012 Mar 3.Светлова МС. Остеоартроз тазобедренного сустава: клиника, диагностика, подходы к лечению. Современная ревматология. 2013;7(1):46-50. doi: 10.14412/1996-7012-2013-2367Svetlova MS. Hip osteoarthrosis: clinical presentation, diagnosis, approaches to treatment. Sovremennaya revmatologiya = Modern Rheumatology Journal. 2013;7(1):46-50. (In Russ.). doi: 10.14412/1996-7012-2013-2367Nevitt MC, Xu L, Zhang YQ, et al. Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing compared to Caucasians in the U.S.: the Beijing Osteoarthritis Study. Arthritis Rheum. 2002 Jul;46(7):1773-9.Nevitt MC, Xu L, Zhang YQ, et al. Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing compared to Caucasians in the U.S.: the Beijing Osteoarthritis Study. Arthritis Rheum. 2002 Jul;46(7):1773-9.Zhang YQ, Xu L, Nevitt MC, et al. Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: the Beijing Osteoarthritis Study. Arthritis Rheum. 2003 Apr;48(4):1034-40.Zhang YQ, Xu L, Nevitt MC, et al. Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: the Beijing Osteoarthritis Study. Arthritis Rheum. 2003 Apr;48(4):1034-40.Wright NC, Riggs GK, Lisse JR, et al. Self-Reported Osteoarthritis, Ethnicity, Body Mass Index, and Other Associated Risk Factors in Postmenopausal Women – Results from the Women's Health Initiative. J Am Geriatr Soc. 2008 Sep;56(9):1736-43. doi: 10.1111/j.1532-5415.2008.01812.x. Epub 2008 Jul 17.Wright NC, Riggs GK, Lisse JR, et al. Self-Reported Osteoarthritis, Ethnicity, Body Mass Index, and Other Associated Risk Factors in Postmenopausal Women – Results from the Women's Health Initiative. J Am Geriatr Soc. 2008 Sep;56(9):1736-43. doi: 10.1111/j.1532-5415.2008.01812.x. Epub 2008 Jul 17.Nelson E, Braga L, Benner J, et al. Characterization of individual radiographic features of hip osteoarthritis in African American and White women and men: the Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken). 2010 Feb;62(2): 190-7. doi: 10.1002/acr.20067.Nelson E, Braga L, Benner J, et al. Characterization of individual radiographic features of hip osteoarthritis in African American and White women and men: the Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken). 2010 Feb;62(2): 190-7. doi: 10.1002/acr.20067.Roman-Blas JA, Castaneda S, Largo R, et al. Osteoarthritis associated with estrogen deficiency. Arthritis Res Ther. 2009;11(5):241. doi: 10.1186/ar2791. Epub 2009 Sep 21.Roman-Blas JA, Castaneda S, Largo R, et al. Osteoarthritis associated with estrogen deficiency. Arthritis Res Ther. 2009;11(5):241. doi: 10.1186/ar2791. Epub 2009 Sep 21.Cirillo DJ, Wallace RB, Wu L, Yood RA. Effect of hormone therapy on risk of hip and knee joint replacement in the Women's Health Initiative. Arthritis Rheum. 2006 Oct; 54(10):3194-204.Cirillo DJ, Wallace RB, Wu L, Yood RA. Effect of hormone therapy on risk of hip and knee joint replacement in the Women's Health Initiative. Arthritis Rheum. 2006 Oct; 54(10):3194-204.Feresin RG, Elam M, Zhao Y, et al. The relationships between sex hormones and osteoarthritis. FASEB Journal. 2013; 27(1):1053.15.Feresin RG, Elam M, Zhao Y, et al. The relationships between sex hormones and osteoarthritis. FASEB Journal. 2013; 27(1):1053.15.Bay-Jensen AC, Slagboom E, Chen-An P, et al. Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis. Menopause. 2013 May;20(5):578-86. doi: 10.1097/GME.0b013e3182745993.Bay-Jensen AC, Slagboom E, Chen-An P, et al. Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis. Menopause. 2013 May;20(5):578-86. doi: 10.1097/GME.0b013e3182745993.Spector TD, MacGregor AJ. Risk factors for osteoarthritis: genetics. Osteoarthritis Cartilage. 2004;12 Suppl A:S39-44.Spector TD, MacGregor AJ. Risk factors for osteoarthritis: genetics. Osteoarthritis Cartilage. 2004;12 Suppl A:S39-44.Kerkhof HJ, Lories RJ, Meulenbelt I, et al. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum. 2010 Feb; 62(2):499-510. doi: 10.1002/art.27184.Kerkhof HJ, Lories RJ, Meulenbelt I, et al. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum. 2010 Feb; 62(2):499-510. doi: 10.1002/art.27184.Murray RO. The aetiology of primary osteoarthritis of the hip. Br J Radiol. 1965 Nov;38(455):810-24.Murray RO. The aetiology of primary osteoarthritis of the hip. Br J Radiol. 1965 Nov;38(455):810-24.Stulberg SD, Cooperman DR, Wallensten R. The natural history of LeggCalve-Perthes disease. J Bone Joint Surg Am. 1981 Sep;63(7):1095-108.Stulberg SD, Cooperman DR, Wallensten R. The natural history of LeggCalve-Perthes disease. J Bone Joint Surg Am. 1981 Sep;63(7):1095-108.Harris WH. Etiology of osteoarthritis of the hip. Clin Orthop Relat Res. 1986 Dec; (213):20-33. 45. Fernandez-Moreno M, Rego I, CarreiraGarcia V. Genetics in Osteoarthritis. Curr Genomics. 2008 Dec;9(8):542-7. doi: 10.2174/138920208786847953.Harris WH. Etiology of osteoarthritis of the hip. Clin Orthop Relat Res. 1986 Dec; (213):20-33. 45. Fernandez-Moreno M, Rego I, CarreiraGarcia V. Genetics in Osteoarthritis. Curr Genomics. 2008 Dec;9(8):542-7. doi: 10.2174/138920208786847953.Стребкова ЕА, Алексеева ЛИ. Остеоартроз и ожирение. Научно-практическая ревматология. 2015;53(5):542-52. doi: 10.14412/1995-4484-2015-542-552Strebkova EA, Alekseeva LI. Osteoarthritis and obesity. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2015;53(5):542-52. (In Russ.). doi: 10.14412/1995-4484-2015-542-552Насонова ВА, Мендель ОИ, Денисов ЛН и др. Остеоартроз и ожирение: клинико-патогенетические взаимосвязи. Профилактическая Медицина. 2011;(1):29-37.Nasonova VA, Mendel' OI, Denisov LN, et al. Osteoarthritis and obesity: clinical and pathogenetic relationships. Profilakticheskaya Meditsina. 2011;(1):29-37. (In Russ.).Jiang L, Tian W, Wang Y, et al. Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine. 2012 May;79(3):291-7. doi: 10.1016/j.jbspin.2011.05.015. Epub 2011 Jul 30.Jiang L, Tian W, Wang Y, et al. Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine. 2012 May;79(3):291-7. doi: 10.1016/j.jbspin.2011.05.015. Epub 2011 Jul 30.Felson DT, Zhang Y, Anthony JM, et al. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med. 1992 Apr 1;116(7):535-9.Felson DT, Zhang Y, Anthony JM, et al. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med. 1992 Apr 1;116(7):535-9.Reijman M, Pols H, Bergink AP, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam study. Ann Rheum Dis. 2007 Feb;66(2):158-62. Epub 2006 Jul 12.Reijman M, Pols H, Bergink AP, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam study. Ann Rheum Dis. 2007 Feb;66(2):158-62. Epub 2006 Jul 12.Lievence AM, Bierma-Zeinstra SM, Verhagen AP, et al. Influence of obesity on the development of osteoarthritis of the hip: a systematic review. Rheumatology (Oxford). 2002 Oct;41(10):1155-62.Lievence AM, Bierma-Zeinstra SM, Verhagen AP, et al. Influence of obesity on the development of osteoarthritis of the hip: a systematic review. Rheumatology (Oxford). 2002 Oct;41(10):1155-62.Алексенко ЕЮ, Говорин АВ, Цвингер СМ. Медиаторы воспаления у больных остеоартрозом в сочетании с артериальной гипертензией. Медицинская иммунология. 2010;12(4-5):429-32.Aleksenko EYu, Govorin AV, Tsvinger SM. Mediators of inflammation in patients with osteoarthritis in combination with hypertension. Meditsinskaya immunologiya. 2010; 12(4-5):429-32. (In Russ.).Mabey T, Honsawek S. Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives. Int J Endocrinol. 2015; 2015:383918. doi: 10.1155/2015/383918. Epub 2015 Jul 2.Mabey T, Honsawek S. Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives. Int J Endocrinol. 2015; 2015:383918. doi: 10.1155/2015/383918. Epub 2015 Jul 2.McAlindon TE, Felson DT, Zhang Y, et al. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med. 1996 Sep 1;125(5):353-9.McAlindon TE, Felson DT, Zhang Y, et al. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med. 1996 Sep 1;125(5):353-9.Laslett LL, Quinn S, Burgess JR, et al. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study. Ann Rheum Dis. 2014 Apr;73(4):697-703. doi: 10.1136/annrheumdis-2012-202831. Epub 2013 Apr 17.Laslett LL, Quinn S, Burgess JR, et al. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study. Ann Rheum Dis. 2014 Apr;73(4):697-703. doi: 10.1136/annrheumdis-2012-202831. Epub 2013 Apr 17.Thomas S, Browne H, Mobasheri A, et al. What is the evidence for a role for diet and nutrition in osteoarthritis? Rheumatology (Oxford). 2018 May 1;57(suppl №4): iv61-iv74. doi: 10.1093/rheumatology/key011.Thomas S, Browne H, Mobasheri A, et al. What is the evidence for a role for diet and nutrition in osteoarthritis? Rheumatology (Oxford). 2018 May 1;57(suppl №4): iv61-iv74. doi: 10.1093/rheumatology/key011.Misra D, Booth SL, Tolstykh I, et al. Vitamin K deficiency is associated with incident knee osteoarthritis. Am J Med. 2013 Mar; 126(3):243-8. doi: 10.1016/j.amjmed.2012.10.011.Misra D, Booth SL, Tolstykh I, et al. Vitamin K deficiency is associated with incident knee osteoarthritis. Am J Med. 2013 Mar; 126(3):243-8. doi: 10.1016/j.amjmed.2012.10.011.Magana-Villa MC, Rocha-Gonzalez HI, Fernandez del Valle-Laisequilla C, et al. B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study. Drug Res (Stuttg). 2013 Jun;63(6):289-92. doi: 10.1055/s-0033-1334963. Epub 2013 Mar 22.Magana-Villa MC, Rocha-Gonzalez HI, Fernandez del Valle-Laisequilla C, et al. B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study. Drug Res (Stuttg). 2013 Jun;63(6):289-92. doi: 10.1055/s-0033-1334963. Epub 2013 Mar 22.Li X, Dong Z, Zhang F, et al. Vitamin E slows down the progression of osteoarthritis. Exp Ther Med. 2016 Jul;12(1):18-22. Epub 2016 May 10.Li X, Dong Z, Zhang F, et al. Vitamin E slows down the progression of osteoarthritis. Exp Ther Med. 2016 Jul;12(1):18-22. Epub 2016 May 10.Wluka AE, Stuckey S, Brand C, Cicuttini FM. Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study. J Rheumatol. 2002 Dec;29(12):2585-91.Wluka AE, Stuckey S, Brand C, Cicuttini FM. Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study. J Rheumatol. 2002 Dec;29(12):2585-91.McAlindon TE, Jacques P, Zhang Y, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum. 1996 Apr; 39(4):648-56.McAlindon TE, Jacques P, Zhang Y, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum. 1996 Apr; 39(4):648-56.Jordan JM, De Roos AJ, Renner JB, et al. A case-control study of serum tocopherol levels and the alpha- to gamma-tocopherol ratio in radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project. Am J Epidemiol. 2004 May 15; 159(10):968-77.Jordan JM, De Roos AJ, Renner JB, et al. A case-control study of serum tocopherol levels and the alpha- to gamma-tocopherol ratio in radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project. Am J Epidemiol. 2004 May 15; 159(10):968-77.Croft P, Cooper C, Wickham C, Coggon D. Osteoarthritis of the hip and occupational activity. Scand J Work Environ Health. 1992 Feb;18(1):59-63.Croft P, Cooper C, Wickham C, Coggon D. Osteoarthritis of the hip and occupational activity. Scand J Work Environ Health. 1992 Feb;18(1):59-63.Thelin A, Vingard E, Holmberg S. Osteoarthritis of the hip joint and farm work. Am J Ind Med. 2004 Feb;45(2):202-9.Thelin A, Vingard E, Holmberg S. Osteoarthritis of the hip joint and farm work. Am J Ind Med. 2004 Feb;45(2):202-9.Lawrence JS. Rheumatism in cotton opertatives. Br J Ind Med. 1961 Oct;18:270-6.Lawrence JS. Rheumatism in cotton opertatives. Br J Ind Med. 1961 Oct;18:270-6.Hadler NM, Gillings DB, Imbus HR, et al. Hand structure and function in an industrial setting. Arthritis Rheum. 1978 Mar; 21(2):210-20.Hadler NM, Gillings DB, Imbus HR, et al. Hand structure and function in an industrial setting. Arthritis Rheum. 1978 Mar; 21(2):210-20.Haara MM, Manninen P, Kroger H, et al. Osteoarthritis of finger joint in Finns ages 30 or over prevalence, determinants and association with mortality. Ann Rheum Dis. 2003 Feb; 62(2):151-8.Haara MM, Manninen P, Kroger H, et al. Osteoarthritis of finger joint in Finns ages 30 or over prevalence, determinants and association with mortality. Ann Rheum Dis. 2003 Feb; 62(2):151-8.

The authors declare that there are no conflicts of interest present.