mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2019-3-71-75mrj-926Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSОпыт применения канакинумаба у пациента с подагрой и IgA-нефропатиейExperience with canakinumab in a patient with gout and IgA nephropathyИльиныхЕ. В.IlyinykhE. V.

Ильиных Екатерина Валериевна.

115522, Москва, Каширское шоссе, 34А.

Ekaterina Valerievna Ilyinykh.

34A, Kashirskoe Shosse, Moscow 115522.

kater1104@yahoo.comЕлисеевМ. С.EliseevM. S.

115522, Москва, Каширское шоссе, 34А.

34A, Kashirskoe Shosse, Moscow 115522.

Научно-исследовательский институт ревматологии им. В.А. НасоновойРоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation2019160920191337175Copyright © Ильиных Е.В., Елисеев М.С., 20192019Ильиных Е.В., Елисеев М.С.Ilyinykh E.V., Eliseev M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/926

В статье обсуждаются результаты применения в клинической практике ингибитора интерлейкина 1/3 канакинумаба у пациента с хронической тофусной подагрой, IgA-нефропатией и хронической болезнью почек, резистентностью к терапии традиционными противовоспалительными препаратами (колхицин, нестероидные противовоспалительные препараты — НПВП, высокие дозы глюкокортикоидов) и неудачным опытом предшествующей уратснижающей терапии. Продемонстрирована возможность безопасного применения канакинумаба в дозе 150 мг подкожно, превосходящего по эффективности высокодозную терапию преднизолоном (40—80 мг/сут) и НПВП. Канакинумаб также обеспечивал снижение риска обострений артрита при подборе уратснижающей терапии.

The paper discusses the results of clinically using the interleukin-1_ inhibitor canakinumab in a patient with chronic tophaceous gout, IgA nephropathy, and chronic kidney disease with resistance to traditional anti-inflammatory drugs (colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs), and high-dose glucocorticoids) and a history of failed urate-lowering therapy. It demonstrates the possibility of safely using subcutaneous canakinumab 150 mg that is superior to therapy with high-dose prednisone (40-80 mg/day) and NSAIDs. Canakinumab has also reduced the risk of exacerbations of arthritis when choosing urate-lowering therapy.

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The authors declare that there are no conflicts of interest present.