mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2019-3-135-141mrj-946Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯОб антикоагулянтных и антиагрегантных свойствах молекулы глюкозамина сульфатаOn the anticoagulant and antiaggregatory properties of a glucosamine sulfate moleculeТоршинИ. Ю.TorshinI. Yu.

119333, Москва, Вавилова, 44, корп. 2.

44, Vavilov St., Build. 2, Moscow 119333.

ЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр.1.

34A, Kashirskoe Shosse, Moscow 115522; 2/1, Barrikadnaya St., Build. 1, Moscow 125993.

ГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна.

119333, Москва, Вавилова, 44, корп. 2.

Olga Alekseevna Gromova.

44, Vavilov St., Build. 2, Moscow 119333.

unesco.gromova@gmail.comНаумовА. В.NaumovA. V.

129226, Москва, ул.1-я Леонова,16.

ГромовА. Н.GromovA. N.

119333, Москва, Вавилова, 44, корп. 2.

44, Vavilov St., Build. 2, Moscow 119333.

Федеральный исследовательский центр «Информатика и управление» Российской академии наук, Институт фармакоинформатикиРоссияInstitute of Pharmacoinformatics, Federal Research Center «Informatics and Management, Russian Academy of SciencesRussian FederationНаучно-исследовательский институт ревматологии им. В.А. Насоновой; кафедра ревматологии Российской медицинской академии непрерывного профессионального образования Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России — ОСП «Российский геронтологический научно-клинический центр»РоссияRussian Gerontology Research and Clinical Center, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation201919092019133135141Copyright © Торшин И.Ю., Лила А.М., Громова О.А., Наумов А.В., Громов А.Н., 20192019Торшин И.Ю., Лила А.М., Громова О.А., Наумов А.В., Громов А.Н.Torshin I.Y., Lila A.M., Gromova O.A., Naumov A.V., Gromov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/946

Глюкозамин — часть метаболома человека, необходимая для биосинтеза биополимерных глюкозаминогликанов соединительной ткани. Кроме того, молекула глюкозамина и сама по себе проявляет противовоспалительные и регенеративные свойства. В настоящей работе представлены результаты систематического анализа фундаментальных и клинических исследований, указывающие на антикоагулянтные и антиагрегантные эффекты высокоочищенной фармацевтической субстанции микрокристаллического глюкозамина сульфата (мГС). Основными молекулярными механизмами его антитромботических эффектов являются, по-видимому, мимикрия молекулой мГС активности гепарансульфатов, активация рецептора CD44 и инактивация сигнальных каскадов NF-kB тромбоцитов. Результаты количественного хемореактомного исследования показали, что вреактоме человека анти-тромботические эффекты мГС обусловлены ингибированием: ’) собственно агрегации тромбоцитов; 2) адгезии и рецепторов активации тромбоцитов; 3) эндогенного синтеза тромбоксанов; 4) коагуляции посредством снижения активности факторов свертывания крови.

Glucosamine is part of the human metabolome required for the biosynthesis of polymer glycosaminoglycans in connective tissue. In addition, the glucosamine molecule itself has anti-inflammatory and regenerative properties. This paper presents the results of a systematic analysis of fundamental and clinical studies, which indicate the anticoagulant and antiaggregatory effects of a highly purified pharmaceutical substance of microcrystalline glucosamine sulfate (mGS). The main molecular mechanisms of its antithrombotic effects are most probably the mGS molecular mimicry of heparan sulfate activity, the activation of CD44 receptor, and the inactivation of the NF-KB signaling pathways in platelets. A quantitative chemoreactome study has shown that the antithrombotic effects of mGS in the human reactome are due to the inhibition of: ’) proper platelet aggregation; 2) platelet adhesion and activation receptors; 3) endogenous synthesis of thromboxanes; 4) coagulation by reducing the activity of coagulation factors.

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