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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2019-4-96-98</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-965</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Опыт применения метотрексата у пациента с болезнью депонирования кристаллов пирофосфата кальция</article-title><trans-title-group xml:lang="en"><trans-title>Experience with methotrexate in a patient with calcium pyrophosphate crystal deposition disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ильиных</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ilyinykh</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Екатерина Валериевна Ильиных</p><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>Ekaterina Valerievna Ilyinkh</p><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><email xlink:type="simple">kater1104@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елисеев</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Eliseev</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>10</month><year>2019</year></pub-date><volume>13</volume><issue>4</issue><fpage>96</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ильиных Е.В., Елисеев М.С., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Ильиных Е.В., Елисеев М.С.</copyright-holder><copyright-holder xml:lang="en">Ilyinykh E.V., Eliseev M.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/965">https://mrj.ima-press.net/mrj/article/view/965</self-uri><abstract><p>В статье обсуждаются результаты применения в реальной клинической практике метотрексата (МТ) у пациента с болезнью депонирования кристаллов пирофосфата кальция, резистентного к терапии традиционными противовоспалительными препаратами (колхицин, нестероидные противовоспалительные препараты, гидроксихлорохин). Продемонстрированы эффективность и возможность безопасного назначения МТ в дозе 20 мг/нед на протяжении года.</p></abstract><trans-abstract xml:lang="en"><p>The paper discusses the results of using methotrexate (MTX) in real clinical practice in a patient with calcium pyrophosphate crystal deposition resistant to traditional anti-inflammatory drugs (colchicine, nonsteroidal anti-inflammatory drugs, and hydroxychloroquine) It demonstrates the efficiency and possibility of safely using MTX at a dose of 20 mg/week during a year.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пирофосфатная артропатия</kwd><kwd>болезнь депонирования кристаллов пирофосфата кальция</kwd><kwd>хронический артрит</kwd><kwd>метотрексат</kwd><kwd>колхицин</kwd><kwd>гидроксихлорохин</kwd><kwd>нестероидные противовоспалительные препараты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pyrophosphate arthropathy</kwd><kwd>calcium pyrophosphate crystal deposition disease</kwd><kwd>chronic arthritis</kwd><kwd>methotrexate</kwd><kwd>colchicine</kwd><kwd>hydroxychloroquine</kwd><kwd>nonsteroidal anti-inflammatory drugs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson K, Terkeltaub R. 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