mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2019-4-104-109mrj-967Research ArticleОБЗОРЫREVIEWSКостно-мышечные потери у больных анкилозирующим спондилитомMusculoskeletal losses in patients with ankylosing spondylitisРаскинаТ. А.RaskinaT. A.

Татьяна Алексеевна Раскина

650056, Кемерово, ул. Ворошилова, 22А

Tatiana Alekseevna Raskina

22A, Voroshilov St., Kemerovo 650056

rassib@mail.ruГригорьеваИ. И.GrigorievaI. I.

650056, Кемерово, ул. Ворошилова, 22А

22A, Voroshilov St., Kemerovo 650056

МалышенкоО. С.MalyshenkoO. S.

650056, Кемерово, ул. Ворошилова, 22А

22A, Voroshilov St., Kemerovo 650056

ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава РоссииРоссияKemerovo State Medical University, Ministry of Health of RussiaRussian Federation201923102019134104109Copyright © Раскина Т.А., Григорьева И.И., Малышенко О.С., 20192019Раскина Т.А., Григорьева И.И., Малышенко О.С.Raskina T.A., Grigorieva I.I., Malyshenko O.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/967

Анкилозирующий спондилит (АС) – одно из наиболее распространенных аутовоспалительных заболеваний, приводящих к ранней утрате трудоспособности больных и высокому уровню преждевременной смертности. Наряду со снижением минеральной плотности кости для больных АС характерно и уменьшение мышечной массы – саркопения. Костно-мышечные потери, обусловленные хроническим иммунным воспалением и ограничением физического функционирования, значительно ухудшают прогноз и обусловливают высокий риск падений и переломов у больных АС.

В обзоре рассмотрены патогенетические механизмы взаимосвязи АС и саркопении и основные подходы к лечению дегенеративных изменений мышечной ткани у больных АС.

Ankylosing spondylitis (AS) is one of the most common autoinflammatory diseases that lead to early disability and high premature mortality rates. Along with lower bone mineral density, patients with AS are characterized by muscle mass decrease, such as sarcopenia. Musculoskeletal losses due to chronic immune inflammation and limited physical functioning significantly worsen prognosis and result in an increased risk of falls and fractures in patients with AS.

The review considers the pathogenetic mechanisms of the relationship between AS and sarcopenia and the main approaches to treating degenerative changes in muscle tissue in patients with AS.

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The authors declare that there are no conflicts of interest present.