mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2019-4-110-115mrj-968Research ArticleОБЗОРЫREVIEWSГолимумаб в лечении внескелетных проявлений анкилозирующего спондилитаGolimumab in the treatment of extra-skeletal manifestations of ankylosing spondylitisДёминаА. Б.DeminaA. B.

Анастасия Борисовна Дёмина

115522, Москва, Каширское шоссе, 34А

Anastasia Borisovna Demina

34A, Kashirskoe Shosse, Moscow 115522

deminaab@yandex.ruФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation201923102019134110115Copyright © Дёмина А.Б., 20192019Дёмина А.Б.Demina A.B.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/968

Внескелетные проявления (ВП) анкилозирующего спондилита (АС) могут возникать и протекать параллельно с воспалительными изменениями со стороны суставов и позвоночника и зачастую выходят на первый план в клинической картине АС, определяя его высокую активность и значимо ухудшая качество жизни пациентов. В ряде случаев ВП характеризуются недостаточным ответом на стандартную противовоспалительную терапию, которая применяется при боли в спине, артрите, энтезите, и возникает необходимость в назначении другого класса лекарственных средств.

В обзоре освещены результаты исследований эффективности голимумаба (ГЛМ) при лечении ВП у больных АС: увеита – GO-EASY Study и язвенного колита (ЯК) – PURSUIT-SC, PURSUIT-М. Анализ данных исследований показал высокую эффективность и безопасность ГЛМ в отношении уменьшения клинических проявлений АС и предотвращения обострений увеита и ЯК. Однако, несмотря на достигнутые успехи в лечении АС и его ВП, остается много нерешенных вопросов, в том числе касающихся разработки оптимальных схем лечения, что требует проведения более длительных наблюдательных исследований с большим размером выборок.

Extra-skeletal manifestations (EMs) of ankylosing spondylitis (AS) can occur and proceed in parallel with inflammatory changes in the joints and spine and often dominate in the clinical picture of AS, determining its high activity and significantly worsening the quality of life in patients. In a number of cases, EMs are characterized by an insufficient response to standard anti-inflammatory therapy for back pain, arthritis, and enthesitis; and there is a need to prescribe another class of drugs.

The review highlights the results of studies evaluating the efficacy of golimumab (GLM) in treating EMs in patients with AS: uveitis (GO-EASY Study) and ulcerative colitis (UC) (PURSUIT-SC, PURSUIT-M studies). Analysis of these studies have shown the high efficacy and safety of GLM in reducing the clinical manifestations of AS and in preventing the exacerbations of uveitis and UC. However, despite the successes achieved in treating AS and its EMs, there are many unresolved issues, including those related to the elaboration of optimal treatment regimens, which required longer observational studies with a large sample size.

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The authors declare that there are no conflicts of interest present.