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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2019-4-130-136</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-971</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Остеоартрит суставов кистей: патогенез, диагностика, подходы к терапии</article-title><trans-title-group xml:lang="en"><trans-title>Hand osteoarthritis: pathogenesis, diagnosis, and approaches to therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шостак</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shostak</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Natalia Grigoryevna Pravdyuk</p><p>1, Ostrovityanov St., Moscow 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Правдюк</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Pravdyuk</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Григорьевна Правдюк</p><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>1, Ostrovityanov St., Moscow 117997</p></bio><email xlink:type="simple">pravda547@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра ревматологии РМАНПО</p><p>115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522; 2/1, Barrikadnaya St., Build. 1, Moscow 125993</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Громова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gromova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119333, Москва, Вавилова, 44, корп. 2</p></bio><bio xml:lang="en"><p>44, Vavilov St., Build. 2, Moscow 119333</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I. Pirogov Russian National Research Medical University, Ministry of Heath of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральный исследовательский центр «Информатика и управление» Российской академии наук, Институт фармакоинформатики</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>10</month><year>2019</year></pub-date><volume>13</volume><issue>4</issue><fpage>130</fpage><lpage>136</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шостак Н.А., Правдюк Н.Г., Лила А.М., Громова О.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Шостак Н.А., Правдюк Н.Г., Лила А.М., Громова О.А.</copyright-holder><copyright-holder xml:lang="en">Shostak N.A., Pravdyuk N.G., Lila A.M., Gromova O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/971">https://mrj.ima-press.net/mrj/article/view/971</self-uri><abstract><p>Остеоартрит (ОА) – широко распространенное заболевание, сопровождающееся стойким поражением суставов с выраженной функциональной недостаточностью, что приводит к ранней инвалидизации больных. При ОА в патологический процесс вовлекаются различные группы суставов. Одной из классических локализаций ОА являются суставы кистей. Обсуждается роль механической нагрузки, генетических факторов, дефицита половых гормонов в развитии заболевания. Лечебная тактика включает сочетание нефармакологических, фармакологических и хирургических методов.</p></abstract><trans-abstract xml:lang="en"><p>Osteoarthritis (OA) is a widespread disease accompanied by persistent joint damage with obvious functional failure, which leads to early disability in patients. In OA, different groups of joints are involved in the pathological process. Hand joints are one of the classical sites of OA. The paper discusses the role of mechanical load, genetic factors, and sex hormone deficiency in the development of the disease. The treatment policy includes a set of non-pharmacological, pharmacological, and surgical methods.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит суставов кистей</kwd><kwd>нестероидные противовоспалительные препараты</kwd><kwd>капсаицин</kwd><kwd>хондроитина сульфат</kwd><kwd>глюкозамина сульфат</kwd><kwd>Хондрогард</kwd><kwd>Сустагард Артро</kwd><kwd>витамин D</kwd><kwd>эстрогенсодержащие препараты</kwd><kwd>таргетная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hand osteoarthritis</kwd><kwd>nonsteroidal anti-inflammatory drugs</kwd><kwd>capsaicin</kwd><kwd>chondroitin sulfate</kwd><kwd>glucosamine sulfate</kwd><kwd>Chondroguard</kwd><kwd>Sustaguard Arthro</kwd><kwd>vitamin D</kwd><kwd>estrogen-containing drugs</kwd><kwd>targeted therapy</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация статьи поддержана ЗАО «ФармФирма «Сотекс».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y, Jordan JM. 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