The state of the oral microflora in patients with systemic sclerosis
https://doi.org/10.14412/1996-7012-2021-5-39-43
Abstract
Systemic sclerosis (SSc) can lead to pathological changes in the maxillofacial region, contributing to the violation of the microbiocenosis of the oral cavity with a predominance of pathogenic microflora.
Objective: to study the composition of the oral microflora in patients with SSc. Patients and methods. The composition of the oral microflora was studied in 50 patients with SSc. The control group consisted of 50 subjects without rheumatic diseases. To assess the intensity of dental caries and the level of oral hygiene we used dental indices: the index of caries intensity (Decayed, Missing, and Filled Teeth (DMFT) and the hygienic index (OHI-S).
Results and discussion. Microbiological examination in patients with SSc revealed pathogenic Staphylococcus aureus and Candida albicans > 10-6 CFU in equal percentage of cases (18.9%), which was significantly more frequent than in the control group (p=0.049). In the oral cavity in SSc, there were no representatives of normal microflora (lactobacilli). In patients with SSc, the DMFT index was 17.8±7.1 on average, and OHI-S – 2.3±0.7, which corresponds to a very high level of caries intensity and low indicators of oral hygiene, respectively. When analyzing the microflora of the oral cavity in 90% of cases, a dysbiotic shift of the 3rd degree was stated.
Conclusion. It can hypothesized that the qualitative and quantitative composition of the microflora of the oral cavity affects the development and severity of inflammatory and destructive pathology of the periodontal and oral mucosa. It is necessary to develop and implement an adapted personal hygiene regimen, including cleansing of the tongue and administration of local probiotics, which, as part of complex therapy, can improve the results of SSc treatment.
About the Authors
M. S. Yesayan
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
Margarita Sanievna Yesayan
18, Trubetskaya Street, Build. 2, Moscow 119991
E. I. Selifanova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
18, Trubetskaya Street, Build. 2, Moscow 119991
E. G. Margaryan
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
18, Trubetskaya Street, Build. 2, Moscow 119991
T. V. Beketova
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
References
1. Guseva NG. Systemic scleroderma is a multidisciplinary problem. Nauchno-prakticheskaya revmatologiya. 2011;49(2):10-4. (In Russ.).
2. Martynova EA, Makeeva IM, Rozhnova EV. The oral cavity as a local ecological system. Stomatologiya. 2008;87(3):68-75. (In Russ.).
3. Beketova TV, Selifanova EI. Periodontal pathology and systemic vasculitis: a look through the prism of interdisciplinary research. Nauchno-prakticheskaya revmatologiya. 2017;55(6):685-9. (In Russ.).
4. Gordeev AV, Galushko EA, Savushkina NM, Lila AM. Is periodontitis a harbinger of rheumatoid arthritis? Nauchno-prakticheskaya revmatologiya. 2018;56(5):613-21. (In Russ.).
5. Molokov VD, Dorzhieva ZV. Indeksnaya otsenka kariesa zubov i zabolevanii parodonta. Metodicheskoe posobie [Index assessment of dental caries and periodontal diseases. Methodological guide]. Irkutsk; 2008. P. 5-10.
6. Tokmakova SI, Butakova LYu, Efremushkin GG, et al. Microflora of the oral mucosa in the elderly with general somatic pathology. Stomatologiya. 2001;(4):24-7. (In Russ.).
7. Grinin VM, Karakhanyan VT. Structure and clinical features of periodontal pathology in systemic scleroderma. Rossiiskaya stomatologiya. 2009;(2):53-5. (In Russ.).
8. Baron M, Hudson M, Dagenais M, et al. Relationship Between Disease Characteristics and Oral Radiologic Findings in Systemic Sclerosis: Results From a Canadian Oral Health Study. Arthritis Care Res (Hoboken). 2016 May;68(5):673-80. doi: 10.1002/acr.22739.
9. Poole JL, Brewer C, Rossie K, et al. Factors related to oral hygiene in persons with scleroderma. Int J Dent Hyg. 2005 Feb; 3(1):13-7. doi: 10.1111/j.1601-5037.2004.00108.x.
10. Thombs BD, Hudson M, Bassel M, et al. Sociodemographic, disease, and symptom correlates of fatigue in systemic sclerosis: evidence from a sample of 659 Canadian Scleroderma Research Group Registry patients. Arthritis Rheum. 2009 Jul 15;61(7):966-73. doi: 10.1002/art.24614.
11. Vincent C, Agard C, Barbarot S, et al. Orofacial manifestations of systemic sclerosis: a study of 30 consecutive patients. Rev Med Interne. 2009 Jan;30(1):5-11. doi: 10.1016/j.revmed.2008.06.012. Epub 2008 Aug 30.
12. Peterson J, Garges S, Giovanni M, et al. The NIH Human Microbiome Project. Genome Res. 2009 Dec;19(12):2317-23. doi: 10.1101/gr.096651.109. Epub 2009 Oct 9.
13. Lamont RDzh, Lantts MS, Berne RA, Leblank DDzh, editors. Mikrobiologiya i immunologiya dlya stomatologov [Microbiology and immunology for dentists]. Moscow: Prakticheskaya meditsina; 2010. 504 p.
14. Selifanova EI, Simonova MV. Odontogenic infection and dysbiosis of the oral cavity in Sjogren's syndrome and disease. Dental Forum Rossiya. 2009;(2):61-5. (In Russ.).
15. Chapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000. 2007;43:160-232. doi: 10.1111/j.1600-0757.2006.00178.x.
16. Mineoka T, Awano S, Rikimaru T, et al. Site-specific development of periodontal disease is associated with increased levels of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia in subgingival plaque. J Periodontol. 2008 Apr;79(4):670-6. doi: 10.1902/jop.2008.070398.
17. Vincent C, Agard C, Barbarot S, et al. Orofacial manifestations of systemic sclerosis: a study of 30 consecutive patients. Rev Stomatol Chir Maxillofac. 2010 Jun;111(3):128-34. doi: 10.1016/j.stomax.2010.04.001. Epub 2010 May 31.
18. Komarovskaya TP. Specific characteristics of the normal intestinal microflora of humans and some types of laboratory animals and pathological foci in purulent-inflammatory diseases of humans. Autoref. diss. cand. med. sci. Moscow; 1984. 30 p.
19. Orehova LJu, Zhavoronkova MD, Suborova TN. Modern technologies of bacteriological research of periodontal spaces. Parodontologiya. 2013;(18): 9-13 (In Russ.).
20. Ushakov RV, Tsarev VN. Antimikrobnaya terapiya v stomatologii. Printsipy i algoritmy [Antimicrobial therapy in dentistry. Principles and algorithms]. Moscow: Prakticheskaya meditsina; 2019. 25 p.
21. Popa ER, Stegeman CA, Abdulahad WH, et al. Staphylococcal toxic-shock-syndrometoxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. Rheumatology (Oxford). 2007 Jun;46(6):1029-33. doi: 10.1093/rheumatology/kem022. Epub 2007 Apr 4.
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For citations:
Yesayan MS, Selifanova EI, Margaryan EG, Beketova TV. The state of the oral microflora in patients with systemic sclerosis. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2021;15(5):39-43. (In Russ.) https://doi.org/10.14412/1996-7012-2021-5-39-43
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