Local and generalized bone loss in rheumatoid arthritis
https://doi.org/10.14412/1996-7012-2021-5-103-107
Abstract
The article presents a review of cross-sectional studies and long-term prospective observations dedicated to changes in bone mineral density (BMD) in patients with rheumatoid arthritis (RA) and factors influencing it. The relationship between local bone loss (erosion count) and generalized BMD loss was noted. It is indicated that existing RA treatment strategies are aimed at suppressing inflammation rather than preventing bone resorption. There is evidence that anti-inflammatory therapy using glucocorticoids, methotrexate, and biologic DMARDs in combination with antiresorptive drugs (bisphosphonates and denosumab) helps prevent BMD loss and the progression of erosions. It is emphasized that osteoporosis in RA, which belongs to the immune-mediated secondary osteopathies, is one of the most frequent and serious complications of RA, which determine the unfavorable course and prognosis of the underlying disease.
Keywords
rheumatoid arthritis,
bone mineral density,
resorption,
X-ray densitometry,
osteoporosis,
bone erosion,
dynamics of bone loss
Supporting agencies: The investigation has been conducted within scientific topic №AAAA-A19-119021190148-3, 0514-2019-0005 «Comorbid infections in rheumatic diseases and safety issues of antirheumatic therapy».
About the Authors
P. S. Kovalenko
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Polina Sergeevna Kovalenko
34A, Kashirskoe Shosse, Moscow 115522
N. I. Kolganova
RUDN University
Russian Federation
Russian Federation
6, Miklukho-Maklaya Street, Moscow 117198
I. S. Dydykina
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
P. O. Kozhevnikova
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
M. Yu. Blank
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
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For citations:
Kovalenko PS, Kolganova NI, Dydykina IS, Kozhevnikova PO, Blank MY. Local and generalized bone loss in rheumatoid arthritis. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2021;15(5):103-107. (In Russ.) https://doi.org/10.14412/1996-7012-2021-5-103-107
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