Janus kinase inhibitors in the treatment of psoriatic arthritis
https://doi.org/10.14412/1996-7012-2022-1-7-13
Abstract
The article presents an analysis of literature data on the use of a new group of targeted synthetic disease-modifying antirheumatic drugs (DMARDs) Janus kinase (JAK) inhibitors – tofacitinib (TOFA) and upadacitinib (UPA) – in psoriatic arthritis (PsA). The results of randomized placebocontrolled clinical trials and long-term observational studies indicate the high efficacy and safety of using TOFA and UPA in the treatment of patients with PsA who are resistant to synthetic DMARDs and tumor necrosis factor-α inhibitors. The information obtained so far allows us to recommend JAK inhibitors as a new pathogenetic approach to the treatment of PsA.
Keywords
psoriatic arthritis,
Janus kinase inhibitors,
tofacitinib,
upadacitinib,
targeted synthetic basic anti-inflammatory drugs
Supporting agencies: The investigation has been conducted within scientific topic № АААА-А19-119021190147-6, 0514-2019-0009 «Pathogenetic features and personalized therapy of ankylosing spondylitis and psoriatic arthritis».
About the Authors
E. Yu. Loginova
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Elena Yurievna Loginova
34A, Kashirskoe shosse, Moscow 115522
T. V. Korotaeva
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe shosse, Moscow 115522
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For citations:
Loginova EY, Korotaeva TV. Janus kinase inhibitors in the treatment of psoriatic arthritis. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2022;16(1):7-13. https://doi.org/10.14412/1996-7012-2022-1-7-13
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