On the prospects for the use of undenatured type II collagen in the treatment of osteoarthritis and other joint diseases
https://doi.org/10.14412/1996-7012-2022-4-111-116
Abstract
Standardized extracts of undenatured type II collagen (UC-II) are used as alternative approaches to the treatment of osteoarthritis (OA). The effect of UC-II extracts is associated with the modulation of the mechanisms of innate and acquired immunity, a decrease in the activity of proinflammatory cytokines and prostaglandins. Epitopes of native collagen in the structure of UC-II contribute to a decrease in the activity of autoimmune reactions that stimulate cartilage degradation. Interacting with discoidin receptors, UC-II accelerates the reconstruction of cartilage connective tissue and inhibits the pro-inflammatory effects of endogenous collagens. Experimental and clinical studies confirm the effectiveness of the use of standardized substances UC-II for acceleration of cartilage regeneration and reduce pain in OA and subclinical joint dysfunction.
Keywords
chondroitin sulfate,
glucosamine sulfate,
undenatured type II collagen,
osteoarthritis therapy,
hyperalgesia,
cytokines,
collagen structure
Supporting agencies: Publication of this article has been supported by Sotex PharmFirma
About the Authors
O. A. Gromova
Institute of Pharmacoinformatics of the Federal Research Center "Computer Science and Management", Russian Academy of Sciences
Russian Federation
Russian Federation
Olga Alekseevna Gromova
44, Vavilov street, building 2, Moscow 119333, Russia
I. Yu. Torshin
Institute of Pharmacoinformatics of the Federal Research Center "Computer Science and Management", Russian Academy of Sciences
Russian Federation
Russian Federation
44, Vavilov street, building 2, Moscow 119333, Russia
A. M. Lila
V.A. Nasonova Research Institute of Rheumatology;
Department of Rheumatology Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522, Russia
2/1, Barrikadnaya street, building 1, Moscow 125993, Russia
O. A. Shavlovskaya
International University of Restorative Medicine
Russian Federation
Russian Federation
8, Furmanny lane, building 2, Moscow 105062, Russia
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For citations:
Gromova OA, Torshin IY, Lila AM, Shavlovskaya OA. On the prospects for the use of undenatured type II collagen in the treatment of osteoarthritis and other joint diseases. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2022;16(4):111-116. (In Russ.) https://doi.org/10.14412/1996-7012-2022-4-111-116
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