Роль нейтрофилов при васкулите, ассоциированном с антинейтрофильными цитоплазматическими антителами
https://doi.org/10.14412/1996-7012-2024-6-90-97
Аннотация
Ассоциированный с антинейтрофильными цитоплазматическими антителами васкулит (ААВ) является потенциально опасным аутоиммунным заболеванием и характеризуется некротизирующим воспалением мелких кровеносных сосудов. В патогенезе AAВ как врожденный, так и адаптивный иммунитет тесно связан с функцией нейтрофилов. Изучение патогенетических механизмов активации нейтрофилов при ААВ может послужить предпосылкой для разработки более точных и современных методов лабораторной диагностики, а также новых подходов к лечению, направленных на нейтрофилы. В обзоре представлен анализ исследований, в которых рассматриваются вопросы активации нейтрофилов при ААВ.
Ключевые слова
ассоциированный с антинейтрофильными цитоплазматическими антителами васкулит,
нейтрофилы,
НЕТоз,
нейтрофильные внеклеточные ловушки
При поддержке: Статья подготовлена в рамках фундаментальной научной темы № 122040400024-7.
Об авторах
Е. Н. Воркель
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
Россия
Евгения Николаевна Воркель
115522, Москва, Каширское шоссе, 34А
Т. М. Решетняк
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия
Россия
115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1
А. М. Лила
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия
Россия
115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1
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Рецензия
Для цитирования:
Воркель ЕН, Решетняк ТМ, Лила АМ. Роль нейтрофилов при васкулите, ассоциированном с антинейтрофильными цитоплазматическими антителами. Современная ревматология. 2024;18(6):90-97. https://doi.org/10.14412/1996-7012-2024-6-90-97
For citation:
Vorkel EN, Reshetnyak TM, Lila AM. The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2024;18(6):90-97. (In Russ.) https://doi.org/10.14412/1996-7012-2024-6-90-97
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