Эпидемиология и генетика васкулитов крупных сосудов. Сообщение 1. Эпидемиологические и молекулярно-генетические аспекты артериита Такаясу

Артериит Такаясу (АТ) – редкое системное заболевание, характеризующееся гранулематозным воспалением, которое поражает крупные артерии, преимущественно аорту и ее ветви. Впервые АТ был описан в Японии, где наблюдается его высокая распространенность, позднее немногочисленные случаи АТ были выявлены и в других этнических группах. Редкие случаи семейной агрегации заболевания позволили предположить вовлечение генетических факторов в патогенез АТ. Почти за 45-летнюю историю изучения генетики АТ не только установлена выраженная взаимосвязь заболевания с антигеном HLA-B5(52)/аллелем HLA-B*5201, но и определены другие HLA и не-HLA молекулярно-генетические маркеры.

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