Rheumatoid arthritis mortality in different countries
https://doi.org/10.14412/1996-7012-2025-6-104-108
Abstract
Rheumatoid arthritis (RA) remains associated with a higher risk of mortality compared to the general population. The prognosis in RA is determined not so much by chronic arthritis as by comorbid diseases. The article presents data on the prevalence and structure of comorbid conditions, as well as the causes of death in patients with RA in different countries. Differences in comorbidity profiles and mortality among RA patients in European, Asian, and African countries are shown.
Supporting agencies: The investigation has not been sponsored
About the Authors
A. O. Plakhova
Tula State University, Medical Institute
Russian Federation
Russian Federation
Anzhela Oktaevna Plakhova
92, Lenina Avenue, Tula 300012
V. N. Sorotskaya
Tula State University, Medical Institute
Russian Federation
Russian Federation
92, Lenina Avenue, Tula 300012
D. Sh. Vaisman
Russian Research Institute of Health, Ministry of Health of Russia
Russian Federation
Russian Federation
11, Dobrolyubova Street, Moscow 127254
References
1. Smolen JS, Aletaha D, Bijsma JWJ, et al. For the T2T Expert Committee. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2010 Apr;69(4):631-7. doi: 10.1136/ard.2009.123919.
2. GBD 2021 Rheumatoid Arthritis Collaborators. Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023 Sep 25;5(10):e594-e610. doi: 10.1016/S2665-9913(23)00211-4.
3. Soriano ER, Mysler E, Rios C, et al. Rheumatoid arthritis in Latin America: pharmacotherapy and clinical challenges. Expert Opin Pharmacother. 2024 Oct;25(15):20232033. doi: 10.1080/14656566.2024.2412247.
4. Burgos Vargas R, Cardiel MH. Rheumatoid arthritis in Latin America. Important challenges to be solved. Clin Rheumatol. 2015 Mar; 34 Suppl 1(Suppl 1):S1-3. doi: 10.1007/s10067-015-3048-1.
5. Adelowo O, Mody GM, Tikly M, et al. Rheumatic diseases in Africa. Nat Rev Rheumatol. 2021 Jun;17(6):363-374. doi: 10.1038/s41584-021-00603-4.
6. Kolou M. Challenges of Rheumatoid Arthritis Management in Sub-Saharan Africa in the 21st Century. Open Journal of Rheumatology and Autoimmune Diseases. 2023;13: 17-40. doi: 10.4236/ojra.2023.131003.
7. Bagepally BS, Kumar SS, Sasidharan A, et al. Household catastrophic health expenditures for rheumatoid arthritis: a single centre study from South India. Sci Rep. 2023 Sep 16; 13(1):15385. doi: 10.1038/s41598-023-42623-y.
8. Gordeev AV, Galushko EA, Savushkina NM, et al. Assessing the multimorbid profile (CIRS) in rheumatoid arthritis. First results. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2019;13 (3):10-16. (In Russ.). doi: 10.14412/1996-7012-20193-10-16.
9. Nasonov EL, Gordeev AV, Galushko EA. Rheumatic diseases and multimorbidity. Terapevticheskii arkhiv. 2015;87(5):4-9. (In Russ.).
10. Widdifield J, Paterson JM, Huang A, Bernatsky S. Causes of Death in Rheumatoid Arthritis: How Do They Compare to the General Population? Arthritis Care Res (Hoboken). 2018 Dec;70(12):1748-1755. doi: 10.1002/acr.23548.
11. Houge IS, Hoff M, Thomas R, et al. Mortality is increased in patients with rheumatoid arthritis or diabetes compared to the general population – the Nord-Trшndelag Health Study. Sci Rep. 2020 Feb 27;10(1):3593. doi: 10.1038/s41598-020-60621-2.
12. Btyszczuk P, Szekanecz Z. Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis. RMD Open. 2020 Jan;6(1):e001032. doi: 10.1136/rmdopen2019-001032.
13. Rebrov AP. Heart damage in patients with rheumatoid arthritis. Yuzhno-Rossiiskii zhurnal terapevticheskoi praktiki. 2022;3(1):15-19. (In Russ.).
14. Plastiras SC, Moutsopoulos HM. Arrhythmias and Conduction Disturbances in Autoimmune Rheumatic Disorders. Arrhythm Electrophysiol Rev. 2021 Apr;10(1):17-25. doi: 10.15420/aer.2020.43.
15. Sordillo PP, Sordillo DC, Helson L. Review: The Prolonged QT Interval: Role of Pro-inflammatory Cytokines, Reactive Oxygen Species and the Ceramide and Sphingosine-1 Phosphate Pathways. In Vivo. 2015 Nov-Dec;29(6):619-36.
16. Ometto F, Fedeli U, Schievano E, et al. Cause-specific mortality in a large population-based cohort of patients with rheumatoid arthritis in Italy. Clin Exp Rheumatol. 2018 Jul-Aug;36(4):636-642.
17. Farhat H, Irfan H, Muthiah K, et al. Increased Risk of Cardiovascular Diseases in Rheumatoid Arthritis: A Systematic Review. Cureus. 2022 Dec 8;14(12):e32308. doi: 10.7759/cureus.32308.
18. Baviera M, Cioffi G, Colacioppo P, et al. Temporal trends from 2005 to 2018 in deaths and cardiovascular events in subjects with newly diagnosed rheumatoid arthritis. Intern Emerg Med. 2021 Sep;16(6):1467-1475. doi: 10.1007/s11739-020-02581-z.
19. Pina Vegas L, Drouin J, Dray-Spira R, Weill A. Prevalence, mortality, and treatment of patients with rheumatoid arthritis: A cohort study of the French National Health Data System, 2010-2019. Joint Bone Spine. 2023 Jan;90(1):105460. doi: 10.1016/j.jbspin.2022.105460.
20. Nakajima A, Inoue E, Tanaka E, et al. Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA. Scand J Rheumatol. 2010;39(5):360-7. doi: 10.3109/03009741003604542.
21. Lee EE, Shin A, Lee J, et al. All-cause and cause-specific mortality of patients with rheumatoid arthritis in Korea: A nation-wide population-based study. Joint Bone Spine. 2022 Jan;89(1):105269. doi: 10.1016/j.jbspin.2021.105269.
22. Lee YK, Ahn GY, Lee J, et al. Excess mortality persists in patients with rheumatoid arthritis. Int J Rheum Dis. 2021 Mar;24(3): 364-372. doi: 10.1111/1756-185X.14058.
23. Jin S, Li M, Fang Y, et al. Chinese Registry of rheumatoid arthritis (CREDIT): II. prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis. Arthritis Res Ther. 2017 Nov 15; 19(1):251. doi: 10.1186/s13075-017-1457-z.
24. Vikash L, Tikly M, Musenge E, Govind N. Comorbidities in Black South Africans with established rheumatoid arthritis. Int J Rheum Dis. 2022 Jun;25(6):699-704. doi: 10.1111/1756-185X.14328.
25. Black RJ, Lester S, Tieu J, et al. Mortality estimates and excess mortality in rheumatoid arthritis. Rheumatology (Oxford). 2023 Nov 2; 62(11):3576-3583. doi: 10.1093/rheumatology/kead106.
Review
For citations:
Plakhova AO, Sorotskaya VN, Vaisman DS. Rheumatoid arthritis mortality in different countries. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2025;19(6):104-108. (In Russ.) https://doi.org/10.14412/1996-7012-2025-6-104-108
Views:
368
JATS XML
Email this article 