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Вопросы иммуногенности биологических препаратов: теория и практика

https://doi.org/10.14412/1996-7012-2009-527

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Аннотация

Рассматривается чрезвычайно многогранная и важная для клинической практики проблема иммуногенности генно-инженерных биологических препаратов, ставших неотъемлемой частью терапии воспалительных ревматических заболеваний.

Об авторе

D E Karateyev



Литература

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Trends Biotechnol 2006;24(6):274-80.</p><p>Насонов Е.Л. Эффективность и безопасность ингибиторов фактора некроза опухоли-а при ревматоидном артрите. РМЖ. 2008;16(24):1602-9.</p><p>Dore R.K., Mathews S., Schechtman J. et al. The immunogenicity, safety, and efficacy of etanercept liquid administered once weekly in patients with rheumatoid arthritis. Clin Exp Rheumatol 2007;25:40-6.</p><p>Wolbink G.J., Vis M., Lems W. et al. Development of antiirfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis. Arthritis Rheum 2006;54(3):711-5.</p><p>Sidiropoulos P.I., Boumpas D.T. A significant number of patients receiving infliximab require dosing adjustments while some patients may indeed develop drug resistance. Ann Rheum Dis 2006;65:701-3.</p><p>Radstake T.R., Svenson M., Eijsbouts A.M. et al. Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis. Ann Rheum Dis 2008; Nov 19, doi:10.1136/ard.2008.092833.</p><p>Van der Bijl A.E., Breedveld F.C., Antoni C.E. et al. An open-label pilot study of the effectiveness of adalimumab in patients with rheumatoid arthritis and previous infliximab treatment: relationship to reasons for failure and anti-infliximab antibody status. Clin Rheumatol 2008;27(8):1021-8.</p><p>Van den Bemt B.J.F., Vos K., Den Broeder A. et al. A single course of rituximab does not abrogate anti-infliximab antibodies in patients with rheumatoid arthritis. Ann Rheum Dis 2008;67(Suppl. II):128.</p></div><br />


Для цитирования:


Karateyev D.E. Вопросы иммуногенности биологических препаратов: теория и практика. Современная ревматология. 2009;3(1):67-72. https://doi.org/10.14412/1996-7012-2009-527

For citation:


Karateyev D.E. The problems of THE immunogenicity of biologicals: theory and practice. Modern Rheumatology Journal. 2009;3(1):67-72. (In Russ.) https://doi.org/10.14412/1996-7012-2009-527

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)