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Современная ревматология

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Безопасность применениягенно-инженерных биологическихпрепаратов при ревматоидном артрите

https://doi.org/10.14412/1996-7012-2010-587

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Аннотация

Представлен обзор современных исследований, посвященных безопасности применения генно-инженерных биологических препаратов (ГИБП) у больных ревматоидным артритом. Указывается, что терапия ГИБП требует тщательного скрининга больных до
начала лечения для исключения инфекционных заболеваний (в том числе туберкулеза) или высокого риска развития инфекции (хронические язвы голени, сахарный диабет тяжелого течения, персистирующая легочная инфекция, наличие мочевого катетера), а
также онкологической патологии, тяжелых заболеваний внутренних органов. Следует учитывать также исходное состояние печени, кардиоваскулярный риск, наличие нейтропении в ответ на использование базисных противовоспалительных препаратов
(БПВП). Отмечено, что при правильном отборе больных и мониторинге возможных нежелательных явлений терапия ГИБП переносится не хуже, чем лечение БПВП.

Литература

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Для цитирования:


Чичасова Н.В., Насонов Е.Л., Чичасова Н.В., Насонов Е.Л. Безопасность применениягенно-инженерных биологическихпрепаратов при ревматоидном артрите. Современная ревматология. 2010;4(1):46-58. https://doi.org/10.14412/1996-7012-2010-587

For citation:


Chichasova N.V., Nasonov E.L., Chichasova N.V., Nasonov E.L. Safety of using genetic engineering biological agents in rheumatoid arthritis. Modern Rheumatology Journal. 2010;4(1):46-58. (In Russ.) https://doi.org/10.14412/1996-7012-2010-587

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)