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Современная ревматология

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Рациональная антимикробная терапияА-стрептококкового тонзиллита -основа первичной профилактикиревматической лихорадки

https://doi.org/10.14412/1996-7012-2011-646

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Аннотация

Проблема острого тонзиллита, вызванного β-гемолитическим стрептококком группы А (БГСА), остается актуальной. Представлены данные, свидетельствующие о возрождении высоковирулентной БГСА-инфекции и нарастании частоты ее осложнений
(острая ревматическая лихорадка, синдром токсического шока), обоснована необходимость рациональной антибактериальной
терапии данной патологии. Препаратами выбора для лечения острых форм БГСА-тонзиллита являются пенициллины (амоксициллин, бензатин-пенициллин, феноксиметилпенициллин) и цефалоспорины I поколения (цефадроксил), а при непереносимости β-лактамных антибиотиков - макролиды (спирамицин, азитромицин, рокситромицин, кларитромицин, джозамицин, мидекамицин).
При наличии хронического рецидивирующего БГСА-тонзиллита, когда вероятность колонизации очага инфекции микроорганизмами, продуцирующими β-лактамазы, достаточно высока, применяют ингибитор-защищенные пенициллины (амоксициллин-клавуланат) или цефалоспорины II поколения (цефуроксим-аксетил). Антибиотики - линкозамины (линкомицин, клиндамицин) используют в терапии острого и хронического БГСА-тонзиллита как препараты резерва.

Литература

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Для цитирования:


Белов Б.С., Белов Б.С. Рациональная антимикробная терапияА-стрептококкового тонзиллита -основа первичной профилактикиревматической лихорадки. Современная ревматология. 2011;5(1):13-22. https://doi.org/10.14412/1996-7012-2011-646

For citation:


Belov B.S., Belov B.S. RATIONAL ANTIMICROBIAL THERAPY FOR GROUP A STREPTOCOCCAL TONSILLITIS IS THE BASIS FOR THE PRIMARYPREVENTION OF RHEUMATIC FEVER. Modern Rheumatology Journal. 2011;5(1):13-22. (In Russ.) https://doi.org/10.14412/1996-7012-2011-646

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)