Ингибитор фактора некроза опухоли α голимумаб в лечении ревматоидного артрита
https://doi.org/10.14412/1996-7012-2014-4-76-85
Аннотация
Для лечения ревматических заболеваний – ревматоидного артрита (РА), анкилозирующего спондилита, псориатического артрита – в 2012 г. в России зарегистрирован ингибитор фактора некроза опухоли (ФНО)α голимумаб (ГЛМ), который представляет собой полностью человеческое моноклональное антитело. Его отличительными чертами являются высокая аффинность к ФНО α, а также удобство применения: препарат вводится 1 раз в месяц подкожно в виде раствора, объемом 0,5 мл. Регистрации препарата предшествовало проведение массивной программы клинических исследований. Рандомизированные плацебоконтролируемые исследования GO-FORWARD, GO-BEFORE, GO-AFTER показали, что ГЛМ эффективен у пациентов с РА из различных подгрупп и обладает благоприятным профилем безопасности, соответствующим таковому всего класса генно-инженерных биологических препаратов. По данным этих исследований, ГЛМ оказывал позитивное влияние на функцию и качество жизни больных РА: отмечено достоверно большее снижение индекса HAQ как в ранние сроки лечения, так и на протяжении длительной открытой фазы (до 5 лет), достоверно большее уменьшение утомляемости, достоверно большее, чем в контрольной группе (р=0,032), улучшение физического и ментального состояния по опроснику SF-36, достоверное уменьшение времени нетрудоспособности.
Об авторе
Наталия Владимировна Чичасова
ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России
Россия
105043, Россия, Москва, ул. Б. Пироговская, д. 2, стр. 4
Россия
105043, Россия, Москва, ул. Б. Пироговская, д. 2, стр. 4
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Рецензия
Для цитирования:
Чичасова НВ. Ингибитор фактора некроза опухоли α голимумаб в лечении ревматоидного артрита. Современная ревматология. 2014;8(4):76-85. https://doi.org/10.14412/1996-7012-2014-4-76-85
For citation:
Chichasova NV. The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2014;8(4):76-85. (In Russ.) https://doi.org/10.14412/1996-7012-2014-4-76-85
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