The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis
https://doi.org/10.14412/1996-7012-2014-4-76-85
Abstract
The tumor necrosis factor-α (TNF-α) golimumab (GLM), that is a fully human monoclonal anti-body, was registered in Russia in 2012 to treat rheumatic diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis, and psoriatic arthritis. Its distinguishing characteristics are a high affinity for TNF-α and easiness-to-use: the drug as a 0.5-ml solution is injected subcutaneously once monthly. The registration of the medication was followed by the implementation of a massive program of clinical trials. The randomized placebo-controlled GO-FORWARD, GO-BEFORE, and GO-AFTER studies have indicated that GLM is effective in patients with RA from different subgroups and has a favorable safety profile as compared to that of the entire class of biological agents. According to the data of these studies, GLM had a positive effect on the functional status and quality of life in patients with RA: there was a significantly greater decrease in HAQ scores in both the early and long open treatment phases (to 5 years) and in fatigability than in the control group (p=0.032), physical and mental health improvements, as shown by the SF-36 questionnaire, and a significant reduction in disability.
About the Author
Natalia Vladimirovna Chichasova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
2, B. Pirogovskaya St., Build. 4, Moscow Russia 105043
Russian Federation
2, B. Pirogovskaya St., Build. 4, Moscow Russia 105043
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For citations:
Chichasova NV. The tumor necrosis factor-α inhibitor golimumab in the treatment of rheumatoid arthritis. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2014;8(4):76-85. (In Russ.) https://doi.org/10.14412/1996-7012-2014-4-76-85
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