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Современная ревматология

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ТАРГЕТНАЯ ТЕРАПИЯ И ИНФЕКЦИИ ПРИ РЕВМАТИЧЕСКИХ ЗАБОЛЕВАНИЯХ

https://doi.org/10.14412/1996-7012-2016-4-4-15

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Аннотация

В последние десятилетия в ревматологии отмечается явный прогресс, связанный с внедрением в практику генно-инженерных биологических препаратов (ГИБП) и таргетных синтетических противовоспалительных препаратов. В то же время применение этих препаратов ассоциируется с нарастающим риском развития инфекций разнообразной природы и локализации, включая оппортунистические (инвазивные микозы, пневмоцистная пневмония и др.), а также повышенный риск реактивации латентной инфекции, в первую очередь туберкулеза (ТБ). Помимо этого регистрируются случаи тяжелых инфекций (пневмония, сепсис, бактериальный артрит, поражение кожи и мягких тканей и др.), в том числе с летальным исходом. В статье проанализированы данные литературы (преимущественно за последние 5 лет), касающиеся частоты и локализации инфекций у больных ревматологического профиля при лечении ГИБП. Охарактеризована значимость различных инфекций (ТБ, пневмонии, хронические вирусные гепатиты, герпес-вирусные инфекции и др.) в тактике курации указанных больных. Подчеркнута необходимость более широкого применения иммунизации различными вакцинами (в первую очередь против гриппа и пневмококковой инфекции) пациентов с аутоиммунными воспалительными ревматическими заболеваниями.

Об авторах

Б. С. Белов
Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия
Контакты: Борис Сергеевич Белов; ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», 115522, Москва, Каширское шоссе, 34A


М. С. Наумцева
Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия


Г. М. Тарасова
Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия


Д. В. Буханова
Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия


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Для цитирования:


Белов Б.С., Наумцева М.С., Тарасова Г.М., Буханова Д.В. ТАРГЕТНАЯ ТЕРАПИЯ И ИНФЕКЦИИ ПРИ РЕВМАТИЧЕСКИХ ЗАБОЛЕВАНИЯХ. Современная ревматология. 2016;10(4):4-15. https://doi.org/10.14412/1996-7012-2016-4-4-15

For citation:


Belov B.S., Naumtseva M.S., Tarasova G.M., Bukhanova D.V. TARGETED THERAPY AND INFECTIONS IN RHEUMATIC DISEASES. Modern Rheumatology Journal. 2016;10(4):4-15. (In Russ.) https://doi.org/10.14412/1996-7012-2016-4-4-15

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)