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Современная ревматология

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ЭЙКОЗАНОИДЫ И ВОСПАЛЕНИЕ

https://doi.org/10.14412/1996-7012-2016-4-73-86

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Аннотация

Воспаление является важнейшим элементом патогенеза основных заболеваний человека. Это определяет принципиальное значение противовоспалительной терапии в современной концепции целенаправленного патогенетического лечения. Рациональный выбор противовоспалительных средств и разработка новых, перспективных препаратов немыслимы без четких знаний особенностей развития воспалительной реакции. Ключевую роль в процессе воспаления играют метаболиты полиненасыщенных жирных кислот – эйкозаноиды. Эти субстанции оказывают разнообразные и часто антагонистические биологические эффекты, что определяется их химической природой и особенностями рецепторов, с которыми они взаимодействуют. Одни из них (простагландины, лейкотриены, эоксины и гепоксилины) являются мощными медиаторами воспаления и боли, другие (липоксины, производные эпоксиэйкозатриеновой кислоты, резолвины, протектины, марезин и эндоканнабиноиды) оказывают противовоспалительное и цитопротективное действие, способствуя разрешению воспалительной реакции. В настоящем обзоре рассмотрены основные классы эйкозаноидов, их метаболизм, эффекты и клиническое значение, а также возможности фармакологического вмешательства в их синтез или взаимодействие с рецепторами. 

Об авторах

А. Е. Каратеев
Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия
Контакты: Андрей Евгеньевич Каратеев; ФБГНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», 115522, Москва, Каширское шоссе, 34А


Т. Л. Алейникова
Первый Московский государственный медицинский университет им. И.М. Сеченова
Россия


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Для цитирования:


Каратеев А.Е., Алейникова Т.Л. ЭЙКОЗАНОИДЫ И ВОСПАЛЕНИЕ. Современная ревматология. 2016;10(4):73-86. https://doi.org/10.14412/1996-7012-2016-4-73-86

For citation:


Karateev A.E., Aleinikova T.L. EICOSANOIDS AND INFLAMMATION. Modern Rheumatology Journal. 2016;10(4):73-86. (In Russ.) https://doi.org/10.14412/1996-7012-2016-4-73-86

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)