Персонифицированная медицина: предикторы эффективности терапии генно-инженерными биологическими препаратами при ревматоидном артрите

Одно из наиболее существенных достижений ревматологии последних десятилетий – внедрение в клиническую практику генно- инженерных биологических препаратов (ГИБП). В то же время стоимость такого лечения очень высока, поэтому большой интерес может представлять разработка методов прогнозирования результатов предполагаемой терапии. В ряде исследований изучаются факторы, определяющие ответ на ГИБП. Публикации, посвященные данной проблеме, очень неоднородны: используются данные, полученные в разных популяциях, а также различные методы исследований и критерии оценки эффективности терапии. В качестве потенциальных предикторов эффективности ГИБП рассматриваются особенности течения заболевания, конституциональные параметры пациента, генетические факторы, наличие коморбидной патологии или сопутствующая терапия. Не исключено, что оптимальный результат может быть получен на основании комплексной оценки этих факторов.

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