Выбор терапевтической тактики при неэффективности первого ингибитора фактора некроза опухоли α
https://doi.org/10.14412/1996-7012-2017-3-106-111
Аннотация
В статье обсуждается возможность достижения эффекта различных генно-инженерных биологических препаратов (ГИБП) у пациентов с активным ревматоидным артритом (РА) при неадекватном ответе на терапию ингибиторами фактора некроза опухоли α (иФНОα). Представлены данные об эффективности у данной группы больных ГИБП с другим механизмом действия (абатацепт, тоцилизумаб, ритуксимаб) и сопоставимой с ними эффективности голимумаба (ГЛМ). Показано, что эффект терапии ГЛМ не зависит от причин отмены предшествующего иФНОα (неэффективность, нежелательные явления и др.). Сделан вывод об эффективности ГЛМ при предшествующем неудачном лечении одним или двумя иФНОα.
Об авторе
Н. В. Чичасова
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»
Россия
Россия
Кафедра ревматологии ИПО
119991, Москва, ул. Трубецкая, 8, стр.2
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Рецензия
Для цитирования:
Чичасова НВ. Выбор терапевтической тактики при неэффективности первого ингибитора фактора некроза опухоли α. Современная ревматология. 2017;11(3):106-111. https://doi.org/10.14412/1996-7012-2017-3-106-111
For citation:
Chichasova NV. Choice of therapeutic tactics after failure of the first tumor necrosis factor-α inhibitor. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2017;11(3):106-111. (In Russ.) https://doi.org/10.14412/1996-7012-2017-3-106-111
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