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Современная ревматология

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Применение базисных противовоспалительных препаратов в терапии остеоартрита

https://doi.org/10.14412/1996-7012-2019-2-90-95

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Аннотация

Остеоартрит (ОА) является гетерогенным заболеванием с различной степенью выраженности воспалительных реакций, структурных изменений, функциональной недостаточности и прогрессирования в целом. Некоторые фенотипы ОА характеризуются высокой локальной воспалительной реакцией, постоянной болью, упорным синовитом и значительным ограничением функциональной активности. Как правило, применение у таких пациентов традиционной терапии нестероидными противовоспалительными препаратами и введение глюкокортикоидов в сустав не оказывают существенного эффекта. Учитывая важную роль воспаления и вовлечение иммунных реакций в патогенез ОА, существование его эрозивных форм, применение некоторых базисных противовоспалительных препаратов могло бы быть рациональным решением проблемы терапии этого заболевания.

Представлен обзор данных, касающихся эффективности и безопасности использования метотрексата и гидроксихлорохина при ОА. 

Об авторах

С. Г. Аникин
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А


Л. И. Алексеева
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А


А. М. Лила
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А


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Для цитирования:


Аникин С.Г., Алексеева Л.И., Лила А.М. Применение базисных противовоспалительных препаратов в терапии остеоартрита. Современная ревматология. 2019;13(2):90-95. https://doi.org/10.14412/1996-7012-2019-2-90-95

For citation:


Anikin S.G., Alekseeva L.I., Lila A.M. Use of disease-modifying anti-rheumatic drugs in the therapy of osteoarthritis. Modern Rheumatology Journal. 2019;13(2):90-95. (In Russ.) https://doi.org/10.14412/1996-7012-2019-2-90-95

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)