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Эффективность внутрисуставной терапии препаратами гиалуроновой кислоты у больных остеоартритом

https://doi.org/10.14412/1996-7012-2019-2-96-104

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Аннотация

Остеоартрит (ОА) – самое распространенное заболевание опорно-двигательного аппарата, характеризующееся постоянной болью, нарушением функции сустава и ранней потерей трудоспособности. В настоящее время встречаемость ОА выросла и, по данным НИИР им. В.А. Насоновой, составляет около 13%, что в 5 раз превышает показатели официальной статистики. Основные цели лечения ОА – уменьшение боли, улучшение функционального состояния сустава, предотвращение развития деформации сустава, улучшение качества жизни пациентов, а также минимизация побочных эффектов фармакотерапии. Препараты гиалуроновой кислоты (ГНК), предназначенные для внутрисуставного введения, долгое время используются как «протез» синовиальной жидкости, однако в недавно опубликованных работах представлены новые данные о механизмах их действия и роли в лечении больных ОА. В многочисленных метаанализах показано, что терапия ГНК по переносимости существенно не отличается от плацебо, обеспечивая при этом значимое уменьшение боли и улучшение функции сустава.

Обзор посвящен некоторым вопросам применения препаратов ГНК для внутрисуставного введения у пациентов с ОА, механизмам действия ГНК, проблемам выбора препарата в зависимости от источника получения, молекулярной массы, методики введения и эффективности терапии по сравнению с другими препаратами. 

Об авторах

Е. А. Стребкова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А


Л. И. Алексеева
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А


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Для цитирования:


Стребкова Е.А., Алексеева Л.И. Эффективность внутрисуставной терапии препаратами гиалуроновой кислоты у больных остеоартритом. Современная ревматология. 2019;13(2):96-104. https://doi.org/10.14412/1996-7012-2019-2-96-104

For citation:


Strebkova E.A., Alekseeva L.I. Efficiency of intra-articular hyaluronic acid therapy in patients with osteoarthritis. Modern Rheumatology Journal. 2019;13(2):96-104. (In Russ.) https://doi.org/10.14412/1996-7012-2019-2-96-104

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)