Apoptosis as a factor for organizing autoimmune inflammation in rheumatoid arthritis
https://doi.org/10.14412/1996-7012-2019-3-95-101
Abstract
The paper summarizes the data available in the literature and those from the authors' studies on the molecular and cellular mechanisms of apoptosis and their state in rheumatoid arthritis (RA). Impaired apoptotic processes in RA are one of the causes of synovial cell hyperactivation that leads to the increased inflammatory process, synovial hyperplasia, and progression of the disease as a whole. The most important feature of a cellular continuum in the affected synovial fluid is the coexistence of just two mechanisms that control apoptosis: 1) a traditional activation mechanism leading to progressive joint inflammation and destruction and 2) an inhibitory mechanism implemented through the expression of proapoptotic molecules. The apoptotic factors are a useful tool for assessing the prognosis of RA and a promising target for pharmacotherapy.
Keywords
chronic rheumatic diseases,
mechanisms of apoptosis,
p53,
Bcl-2,
Mdm2,
PUMA,
caspases,
pharmacotherapy
About the Authors
A. I. Dubikov
Professor A.I. Dubikov Clinic of Rheumatology
Russian Federation
Russian Federation
Aleksandr Ivanovich Dubikov.
42B, Basargin St., Patroclus Bay, Vladivostok 690080.
S. G. Kalinichenko
Pacific State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
2, Ostryakov Prosp., Vladivostok 690002.
N. Yu. Matveeva
Pacific State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
2, Ostryakov Prosp., Vladivostok 690002.
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Review
For citations:
Dubikov AI, Kalinichenko SG, Matveeva NY. Apoptosis as a factor for organizing autoimmune inflammation in rheumatoid arthritis. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2019;13(3):95-101. (In Russ.) https://doi.org/10.14412/1996-7012-2019-3-95-101
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