The risk of fractures and the need for anti-osteoporotic treatment in patients with systemic sclerosis
https://doi.org/10.14412/1996-7012-2021-1-32-37
Abstract
Objective: to estimate the high and very high Frax® 10-year probabilities of fractures in patients with systemic sclerosis (SSc) to assess the need for anti-osteoporotic treatment.
Patients and methods. The investigation enrolled 136 SSc patients (110 women and 26 men; mean age, 59.3±7.5 years). The patients underwent a questionnaire survey, by calculating the risk of major fractures with the FRAX® algorithm and dual-energy X-ray densitometry (DXA) of the lumbar spine and proximal femur.
Results and discussion. There was a very high risk of fractures in 41.2% of the examinees, a high risk in 10.3%, and a low risk in 48.5%. Osteoporosis (OP) in at least one area was detected in 41.2% of the patients. Among the persons with a low risk of fractures, OP was diagnosed in 18.2%, whereas 10.6% had a history of fractures. A total of 65.4% of SSc patients needed anti-osteoporotic treatment.
Conclusion. According to the comprehensive assessment, OP treatment and fracture prevention were indicated for 65.4% of SSc patients. The FRAX® algorithm is less informative in males who need therapy than in females.
About the Authors
A. О. Efremova
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Arina Olegovna Efremova
34A, Kashirskoe Shosse, Moscow 115522
N. V. Toroptsova
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
O. V. Dobrovolskaya
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
N. V. Demin
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
O. A. Nikitinskaya
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
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Review
For citations:
Efremova AО, Toroptsova NV, Dobrovolskaya OV, Demin NV, Nikitinskaya OA. The risk of fractures and the need for anti-osteoporotic treatment in patients with systemic sclerosis. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2021;15(1):32-37. (In Russ.) https://doi.org/10.14412/1996-7012-2021-1-32-37
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