Трансплантация аутологичных гемопоэтических стволовых клеток в лечении системной склеродермии. Часть 2. Безопасность и осложнения

В настоящее время аутотрансплантация гемопоэтических стволовых клеток (аутоТГСК) – единственная болезнь-модифицирующая стратегия лечения системной склеродермии (ССД), имеющая уровень доказательности А, эффективность которой была доказана в трех контролируемых клинических исследованиях – ASSIST, ASTIS, SCOT. Несмотря на позитивные результаты, полученные при использовании данного метода лечения, нерешенными остаются вопросы, связанные с его переносимостью и безопасностью. Осложнения, вызванные выраженной иммуносупрессией и увеличением частоты инфекций, являются главными причинами смерти после аутоТГСК при аутоиммунных заболеваниях и встречаются в основном в первый месяц после лечения. В целом проведенные исследования подтверждают общую оценку аутоТГСК как эффективного и относительно безопасного метода терапии тяжелой формы ССД.

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