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Современная ревматология

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Перспективы применения ингибиторов фактора некроза опухоли α у больных COVID-19

https://doi.org/10.14412/1996-7012-2021-2-89-93

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Аннотация

Обзор посвящен проблеме поиска новых эффективных стратегий лечения коронавирусной болезни (COVID-19). Терапевтической мишенью может стать фактор некроза опухоли α (ФНОα). Приведены теоретические предпосылки успешного использования ингибиторов ФНОα (иФНОα) для лечения COVID-19, описан полученный за время эпидемии практический опыт применения препаратов этой группы, в том числе нашедший отражение в клинических исследованиях. В качестве возможных вариантов терапии рассматриваются два иФНОα – инфликсимаб и адалимумаб. Освещены вопросы безопасности иФНОα при лечении пациентов с иммуновоспалительными ревматическими заболеваниями и с COVID-19. Уделено внимание вакцинации против COVID-19, в частности имеющимся на данный момент в России вакцинам, находящимся на разных этапах клинических испытаний. Сделано заключение о необходимости проведения рандомизированных клинических исследований эффективности и безопасности применения иФНОα при новой коронавирусной инфекции, что позволит перейти от теоретических предпосылок к клинической практике.

Об авторах

Е. С. Аронова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

Евгения Сергеевна Аронова

115522, Москва, Каширское шоссе, 34А



Б. С. Белов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34А



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Для цитирования:


Аронова Е.С., Белов Б.С. Перспективы применения ингибиторов фактора некроза опухоли α у больных COVID-19. Современная ревматология. 2021;15(2):89-93. https://doi.org/10.14412/1996-7012-2021-2-89-93

For citation:


Aronova E.S., Belov B.S. The Prospects of tumor necrosis factor α inhibitors use in patients with COVID-19. Modern Rheumatology Journal. 2021;15(2):89-93. (In Russ.) https://doi.org/10.14412/1996-7012-2021-2-89-93

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)