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Современная ревматология

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Прогрессирование аксиального спондилоартрита

https://doi.org/10.14412/1996-7012-2021-3-7-14

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Аннотация

Разнообразие поражения костной ткани при аксиальном спондилоартрите вызывает большой интерес. На фоне конкурирующих между собой воспаления и механических воздействий на конкретном участке кости одновременно может происходить как прирост ткани, так и ее потеря. Причем, если потерю костной массы позвонков, пожалуй, легко объяснить хроническим системным воспалением, то ее новообразование, наблюдаемое при аксиальном спондилоартрите, остается загадкой. Неясно, является ли оно следствием усиления процессов восстановления после повреждения, адаптации к измененной механической нагрузке, реакции на активацию участвующих в воспалении клеток или продуцируемых ими цитокинов либо изменения в сигнальных путях Wnt (как пример), а также действуют ли эти факторы по отдельности или совокупно?

Об авторах

Ш. Ф. Эрдес
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

Шандор Федорович Эрдес

Россия, 115522, Москва, Каширское шоссе, 34А



Т. В. Коротаева
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

Россия, 115522, Москва, Каширское шоссе, 34А



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Эрдес Ш.Ф., Коротаева Т.В. Прогрессирование аксиального спондилоартрита. Современная ревматология. 2021;15(3):7-14. https://doi.org/10.14412/1996-7012-2021-3-7-14

For citation:


Erdes S.F., Korotaeva T.V. Progression of axial spondyloarthritis. Modern Rheumatology Journal. 2021;15(3):7-14. https://doi.org/10.14412/1996-7012-2021-3-7-14

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)