Impact of age on the frequency and magnitude of the signs of metabolic syndrome in patients with gout

Abstract

Tsel' issledovaniya. Vyyavit' vozrastnye osobennosti metabolicheskogo sindroma (MS) u bol'nykh podagroy.
Material i metody. V issledovanie vklyucheny 202 muzhchiny, stradayushchikh podagroy (kriterii S.L. Wallace). Laboratornye issledovaniya provodili posle kupirovaniya pristupa artrita. U vsekh bol'nykh otsenivali antropometricheskie pokazateli, syvorotochnye urovni mochevoy kisloty, pokazateli lipidnogo obmena. MS diagnostirovali na osnovanii rabochikh kriteriev ekspertov Natsional'nogo instituta zdorov'ya SShA (ATR III). Insulinorezistentnost' (IR) otsenivali s pomoshch'yu indeksa NOMA (Homeostasis Model Assessment). Bol'nye byli raspredeleny na gruppy (<40 let, 40-49 let, 50-59let i ≥60 let).
Rezul'taty issledovaniya. MS diagnostirovan u 67,8% bol'nykh podagroy. Chastota vyyavleniya MS v gruppakh byla sopostavimoy (65% - u bol'nykh <40 let, 70% - u bol'nykh 40-49 let, 64% - u bol'nykh 50-59 let i 73% - u bol'nykh ≥60 let). Vyyavlena pryamaya korrelyatsiya vozrasta s SAD (R=0,24, p=0,0009), DAD (R=0,32, p<0,0001), syvorotochnym urovnem glyukozy (R=0,22, p=0,0083) i obratnaya korrelyatsiya vozrasta s massoy tela (R= -0,28, p=0,0007) i syvorotochnym urovnem triglitseridov (R= -0,20, p=0,0083).
Zaklyuchenie. Chastota vyyavleniya u bol'nykh podagroy MS i IR ne zavisit ot vozrasta. Polucheny dannye, svidetel'stvuyushchie o nalichii vozrastnykh osobennostey MS u bol'nykh podagroy: u molodykh bol'nykh nablyudaetsya bol'shaya vyrazhennost' ozhireniya i gipertriglitseridemii, u pozhilykh narastaet chastota arterial'noy gipertenzii i giperglikemii.