Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout
https://doi.org/10.14412/1996-7012-2021-6-124-129
Abstract
Fatty acids (FA) are present in all types of organisms and play an important role in energy metabolism. The length and number of double bonds in the FA of membrane phospholipids determine the viscosity, the activity of transport systems and enzymes, and also the susceptibility to lipid peroxidation. The review discusses the influence of free unsaturated FAs with short and long chains on various inflammatory mechanisms, including atherosclerosis. It has been shown that FAs can reduce endothelial activation and affect the metabolism of eicosanoids. A new model of fundamental factors determining the variability of the timing, degree and duration of acute inflammatory reactions in the deposition of urate crystals in tissues, in which FAs play an important role is considered, using gout as an example. In the future, the study of FAs will expand the understanding of the pathophysiology of chronic inflammation in various diseases, metabolic disorders and atherosclerosis and enable the development of new treatment strategies.
About the Authors
M. A. Gromova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Department of faculty therapy, Medical faculty,
1, Ostrovitianov street, Moscow 117997
V. V. Tsurko
Pirogov Russian National Research Medical University;
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Department of faculty therapy, Medical faculty, 1, Ostrovitianov street, Moscow 117997;
Department of General Medical Practice of the Institute of Postgraduate Education, 8, Trubetskaya street, building 2, Moscow 119991
O. A. Kislyak
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Department of faculty therapy, Medical faculty,
1, Ostrovitianov street, Moscow 117997
E. V. Kiseleva
N.N. Semenov Federal Research Center for chemical physics
Russian Federation
Russian Federation
Laboratory of Functional Polymer Systems and Composites,
4, Kosygina street, Moscow 119334
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Review
For citations:
Gromova MA, Tsurko VV, Kislyak OA, Kiseleva EV. Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2021;15(6):124-129. (In Russ.) https://doi.org/10.14412/1996-7012-2021-6-124-129
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