Undifferentiated connective tissue dysplasia and knee osteoarthritis: clinical manifestations and the state of carbohydrate metabolism
https://doi.org/10.14412/1996-7012-2022-2-43-47
Abstract
Objective: to evaluate the impact of undifferentiated connective tissue dysplasia (CTD) on the clinical manifestations of primary osteoarthritis (OA) in postmenopausal women.
Patients and methods. The case-control study included 38 postmenopausal women with primary knee OA, radiological stage II. The main group included 19 patients who met the criteria for CTD, the control group included 19 patients without CTD.
Results and discussion. Patients in the control group had significantly higher values of body mass index, hip circumference and more pronounced clinical manifestations of menopausal syndrome. Patients in the control group had all clinical components and laboratory criteria of the metabolic syndrome, they also had greater limitations of joint function compared to patients of the main group. In patients with CTD pathogenetic mechanisms of development and progression of OA differ from the metabolic phenotype of OA.
Conclusion. The dysplastic phenotype of OA develops in the absence of metabolic syndrome and with less functional impairment than the metabolic phenotype. The metabolic phenotype of OA is associated with insulin resistance, more pronounced functional and psycho-emotional disturbances.
About the Authors
A. A. Popov
Ural State Medical University,
Russian Federation
Russian Federation
3, Repin street, Yekaterinburg 620028, Russia
N. V. Izmozherova
Ural State Medical University,
Russian Federation
Russian Federation
3, Repin street, Yekaterinburg 620028, Russia
N. A. Getmanova
Salekhard District Clinical Hospital
Russian Federation
Russian Federation
39, Mira street, Salekhard 629001, Russia
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Review
For citations:
Popov AA, Izmozherova NV, Getmanova NA. Undifferentiated connective tissue dysplasia and knee osteoarthritis: clinical manifestations and the state of carbohydrate metabolism. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2022;16(2):43-47. (In Russ.) https://doi.org/10.14412/1996-7012-2022-2-43-47
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