Viral mixed infection complicated by acute hepatitis and allergic toxic dermatitis (clinical case)
https://doi.org/10.14412/1996-7012-2022-5-71-74
Abstract
Epstein-Barr virus (EBV) belongs to the family of herpesviruses (herpes type 4) and is one of the most common and highly contagious. During the pandemic of a new coronavirus disease, it was found that in patients previously infected with EBV, COVID-19 can cause its reactivation, which is often manifested by the clinic of acute hepatitis. The article presents a clinical case of the development of acute hepatitis in a patient with mixed infection with EBV and SARS-CoV-2 in combination with allergic toxic reaction while taking sulfasalazine prescribed for spondyloarthritis. A feature of this case was the development of severe hepatitis of mixed genesis with a favorable outcome. The importance of adherence to drug monitoring rules for newly prescribed drugs for COVID-19 was emphasized. In severe cases of the disease, the possibility of mixed infection should be taken into account.
About the Authors
E. S. Aronova
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Evgenia S. Aronova
34A, Kashirskoe Shosse, Moscow 115522
B. S. Belov
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
G. I. Gridneva
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
References
1. Nadeem A, Suresh K, Awais H, Waseem S. Epstein-Barr Virus Coinfection in COVID-19. J Investig Med High Impact Case Rep. Jan-Dec 2021;9:23247096211040626. doi: 10.1177/23247096211040626.
2. Brunet-Possenti F, Steff M, Marinho E, et al. Syndrome de Stevens-Johnson au cours d'une primo-infection par le virus d'Epstein-Barr. Ann Dermatol Venereol. 2013 Feb;140(2):112-5. doi: 10.1016/j.annder.2012.10.590. Epub 2012 Dec 10.
3. Federal'nye klinicheskie rekomendatsii po vedeniyu bol'nykh sindromom Stivensa– Dzhonsona / toksicheskim epidermal'nym nekrolizom [Federal clinical guidelines for the management of patients with Stevens—Johnson syndrome / toxic epidermal necrolysis]. Moscow: Rossiiskoe obshchestvo dermatovenerologov i kosmetologov; 2015.
4. Kartashova MG. Stephens-Johnson syndrome. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2012;(6):13-7. (In Russ.).
5. Frantz R, Huang S, Are A, Motaparthi K. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management. Medicina (Kaunas). 2021 Aug 28; 57(9):895. doi: 10.3390/medicina57090895.
6. Frey N, Bodmer M, Bircher A, et al. Stevens–Johnson syndrome and toxic epidermal necrolysis in association with commonly prescribed drugs in outpatient care other than anti-epileptic drugs and antibiotics: A population-based case-control study. Drug Saf. 2019 Jan;42(1):55-66. doi: 10.1007/s40264-018-0711-x.
7. Bulat V, Likic R, Pondeljak N, Azdajic MD. Pholcodine-induced Stevens–Johnson syndrome in a patient with COVID-19. Postgrad Med J. 2022 Jul;98(1161):499-500. doi: 10.1136/postgradmedj-2021-139892. Epub 2021 Apr 20.
8. Muhd Besari A, Lim JA, Vellaichamy PT, et al. Stevens–Johnson syndrome as a primary skin manifestation of COVID-19. Postgrad Med J. 2022 Mar;98(e2):e70. doi: 10.1136/postgradmedj-2021-140778.
9. Abdelgabar A, Elsayed M. Case of erythema multiforme/Stevens-Johnson syndrome: an unusual presentation of COVID-19. J R Coll Physicians Edinb. 2021 Jun;51(2):160-1. doi: 10.4997/JRCPE.2021.214.
10. Pagh P, Rossau AK. COVID-19 induced Stevens–Johnson syndrome. Ugeskr Laeger. 2022 Mar 7;184(10):V10210804.
11. Shahraki T, Hassanpour K, Arabi A, et al. Corona virus disease 2019-associated StevensJohnson syndrome: a case report. BMC Ophthalmol. 2021 Jul 12;21(1):274. doi: 10.1186/s12886-021-02033-y.
12. Manciuc C, Lacatusu GA, Vata A, et al. Concomitance or consequence? Stevens— Johnson syndrome in COVID-19: A case report. Exp Ther Med. 2022 Apr;23(4):257. doi: 10.3892/etm.2022.11182. Epub 2022 Feb 2.
13. Oakley AM, Krishnamurthy K. Stevens– Johnson Syndrome. https://www.ncbi.nlm.nih.gov/books/NBK459323
14. Bardenikova SI, Pen'tkovskaya OS, Isaeva EK. Stevens—Johnson syndrome is an immune catastrophe. Russkii meditsinskii zhurnal. Mat' i ditya. 2019;2(1):66–72. (In Russ.).
15. Mellinger JL, Rossaro L, Naugler WE, et al. Epstein-Barr virus (EBV) related acute liver failure: a case series from the US Acute Liver Failure Study Group. Dig Dis Sci. 2014 Jul; 59(7):1630-7. doi: 10.1007/s10620-014-3029-2. Epub 2014 Jan 25.
16. Phipps MM, Barraza LH, LaSota ED, et al. Acute liver injury in COVID-19: prevalence and association with clinical outcomes in a large US cohort. Hepatology. 2020 Sep;72(3):807-17. doi: 10.1002/hep.31404.
17. Kunoutsuor SK, Laukkanen JA.Hepatic manifestations and complications of COVID-19: a systematic review and meta-analysis. J Infect. 2020 Sep;81(3):e72-e74. doi: 10.1016/j.jinf.2020.06.043. Epub 2020 Jun 21.
18. Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020 May 26;323(20):2052-9. doi: 10.1001/jama.2020.6775.
19. Bongiovanni M, Zago T. Acute hepatitis caused by asymptomatic COVID-19 infection. J Infect. 2021 Jan;82(1):e25-e26. doi: 10.1016/j.jinf.2020.09.001. Epub 2020 Sep 3.
20. Anirvan P, Bharali P, Gogoi M, et al. Liver injury in COVID-19: The hepatic aspect of the respiratory syndrome – what we know so far. World J Hepatol. 2020 Dec 27;12(12): 1182-97. doi: 10.4254/wjh.v12.i12.1182.
21. Chen T, Song J, Liu H, et al. Positive Epstein–Barr virus detection in coronavirus disease 2019 (COVID-19) patients. Sci Rep. 2021 May 25;11(1):10902. doi: 10.1038/s41598-021-90351-y.
22. Nadeem A, Suresh K, Awais H, Waseem S. Epstein–Barr Virus Coinfection in COVID-19. J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211040626. doi: 10.1177/23247096211040626.
23. Paolucci S, Cassaniti I, Novazzi F, et al; San Matteo Pavia COVID-19 Task Force. EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count. Int J Infect Dis. 2021 Mar;104:315-9. doi: 10.1016/j.ijid.2020.12.051. Epub 2020 Dec 21.
Review
For citations:
Aronova ES, Belov BS, Gridneva GI. Viral mixed infection complicated by acute hepatitis and allergic toxic dermatitis (clinical case). Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2022;16(5):71-74. (In Russ.) https://doi.org/10.14412/1996-7012-2022-5-71-74
Views:
771
Email this article 