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Глюкокортикоидиндуцированный остеопороз: патогенез, профилактика, лечение

https://doi.org/10.14412/1996-7012-2008-455

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Аннотация

Глюкокортикоидиндуцированный остеопороз (ГИО) - одно из наиболее тяжелых осложнений длительной (более 3 мес) системной терапии глюкокортикоидами (СГК). Он развивается у больных любого возраста и пола и является наиболее частой системной формой вторичного остеопороза (ОП). Быстрая потеря костной массы происходит уже в первые месяцы лечения СГК. Переломы от минимальной травмы возникают при более высоких показателях минеральной плотности кости, чем у больных первичным ОП. Даже использование малых доз СГК приводит к повышению риска переломов, с увеличением суточной дозы риск переломов возрастает. У пациентов, применяющих высокие дозы ингаляционных ГК (ИГК), увеличение риска ОП и переломов в большей степени обусловлено тяжестью респираторного заболевания, чем терапией ИГК. Представлены современные принципы профилактики и лечения ГИО.

Литература

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Для цитирования:


Баранова И.А., Баранова И.А. Глюкокортикоидиндуцированный остеопороз: патогенез, профилактика, лечение. Современная ревматология. 2008;2(1):31-39. https://doi.org/10.14412/1996-7012-2008-455

For citation:


Baranova I.A., Baranova I.A. Glucocorticosteroid-induced osteoporosis: pathogenesis, prevention, treatment. Modern Rheumatology Journal. 2008;2(1):31-39. (In Russ.) https://doi.org/10.14412/1996-7012-2008-455

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)