Secondary fibromyalgia in children with immune-inflammatory rheumatic diseases
https://doi.org/10.14412/1996-7012-2024-3-99-106
Abstract
Patients with immune-inflammatory rheumatic diseases (IIRDs) often present with non-inflammatory musculoskeletal pain associated with nociceptive dysfunction, central sensitization, and secondary fibromyalgia (FM). In recent years, an increasing number of publications have appeared dealing with FM in rheumatoid arthritis and systemic connective tissue diseases in adult patients, while this problem is little discussed in pediatric rheumatology, partly due to the differences between the existing diagnostic criteria in children and adults, which complicate the diagnosis of juvenile secondary FM. The consequence of this is often the unfounded prescription or switching of synthetic disease-modifying antirheumatic drugs (DMARDs) or biologic DMARDs in patients who do not require intensified antirheumatic therapy, but rather psychotherapy and psychopharmacotherapy, as well as the wider use of physical and rehabilitation medicine methods. In a brief narrative review, we tried to trace the investigation of FM in a rheumatological clinic, including children with IIRD, from a historical perspective, to summarize current literature data on this problem and to point out possible solutions.
Keywords
About the Authors
A. V. SantimovRussian Federation
Andrey Vyacheslavovich Santimov
194100; 2, Litovskaya Street; St. Petersburg
S. V. Grechanyi
Russian Federation
194100; 2, Litovskaya Street; St. Petersburg
G. A. Novik
Russian Federation
194100; 2, Litovskaya Street; St. Petersburg
References
1. Tran G, Gough A. Fibromyalgia remains the elephant in the clinic room. Rheumatology (Oxford). 2023 Oct 3;62(10):3223-3224. doi: 10.1093/rheumatology/kead136.
2. Gowers WR. A Lecture on Lumbago: Its Lessons and Analogues: Delivered at the National Hospital for the Paralysed and Epileptic. Br Med J. 1904 Jan 16;1(2246):117-21. doi: 10.1136/bmj.1.2246.117.
3. Caven WR. Backache and fibrositis; A medical point of view. Can Med Assoc J. 1947 Jul;57(1):37-43.
4. Travell J, Rinzler SH. The myofascial genesis of pain. Postgrad Med. 1952 May;11(5): 425-34. doi: 10.1080/00325481.1952.11694280.
5. Yunus M, Masi AT, Calabro JJ, et al. Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls. Semin Arthritis Rheum. 1981 Aug;11(1):151-71. doi: 10.1016/0049-0172(81)90096-2.
6. Yunus MB, Masi AT. Juvenile primary fibromyalgia syndrome. A clinical study of thirty-three patients and matched normal controls. Arthritis Rheum. 1985 Feb;28(2):138-45. doi: 10.1002/art.1780280205.
7. Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990 Feb;33(2):160-72. doi: 10.1002/art.1780330203.
8. Wolfe F, Clauw DJ, Fitzcharles MA, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken). 2010 May;62(5): 600-10. doi: 10.1002/acr.20140.
9. Harth M, Nielson WR. The fibromyalgia tender points: use them or lose them? A brief review of the controversy. J Rheumatol. 2007 May;34(5):914-22.
10. Ting TV, Barnett K, Lynch-Jordan A, et al. 2010 American College of Rheumatology Adult Fibromyalgia Criteria for Use in an Adolescent Female Population with Juvenile Fibromyalgia. J Pediatr. 2016 Feb;169: 181-7.e1. doi: 10.1016/j.jpeds.2015.10.011.
11. Wolfe F, Clauw DJ, Fitzcharles MA, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016 Dec;46(3):319-329. doi: 10.1016/j.semarthrit.2016.08.012.
12. Arnold LM, Bennett RM, Crofford LJ, et al. AAPT Diagnostic Criteria for Fibromyalgia. J Pain. 2019 Jun;20(6):611-628. doi: 10.1016/j.jpain.2018.10.008.
13. Wolfe F. Letter to the editor, "Fibromyalgia Criteria". J Pain. 2019 Jun;20(6):739-740. doi: 10.1016/j.jpain.2019.02.002.
14. Santimov AV, Chasnyk VG, Grechanyi SV. Psychometric assessment of chronic pain syndrome in juvenile idiopathic arthritis. Pediat. 2019;10(3):25-30. (In Russ.)
15. Santimov AV, Chasnyk VG, Grechanyi SV. The level of anxiety and depression in children and adolescents with chronic pain syndrome (on the example of juvenile idiopathic arthritis). Obozrenie psikhiatrii i meditsinskoi psikhologii imeni V.M. Bekhtereva. 2019;(4-2):78-86 (In Russ.)
16. Santimov AV, Chasnyk VG, Grechanyi SV. The family aspect of chronic pain syndrome in children and adolescents with juvenile idiopathic arthritis. Voprosy psikhicheskogo zdorov'ya detei i podrostkov. 2020;20(3):47-57. (In Russ.)
17. Santimov AV, Chasnyk VG, Grechanyi SV. Psychotherapeutic Approach to the Treatment of Chronic Pain Syndrome in Juvenile Idipathic Arthritis and Predictors of its Effectiveness. Psikhiatriya, psikhoterapiya i klinicheskaya psikhologiya. 2022;13(2):138-150. (In Russ.)
18. Zubareva ES, Generalova DD, Santimov AV, et al. Mental health disorders identification in pediatric patients with juvenile idiopathic arthritis with chronic pain syndrome. Pediatriya im. G.N. Speranskogo. 2023;102 (4):147-158 (In Russ.)
19. Karateev AE. Do not say or write: “pain syndrome”! You say “pain”! Nauchno-Prakticheskaya Revmatologia. 2023;61(6):667-671. (In Russ.)
20. Lisitsyna TA, Abramkin AA, Veltishchev DY, et al. Chronic pain and depression in patients with rheumatoid arthritis: Results of five-year follow-up. Terapevticheskii arkhiv. 2019;91(5): 8-18. (In Russ.)
21. Karateev AE, Nasonov EL. Chronic pain and central sensitization in immuno-inflammatory rheumatic diseases: Pathogenesis, clinical manifestations, the possibility of using targeted disease modifying antirheumatic drugs. Nauchno-Prakticheskaya Revmatologia. 2019; 57(2):197-209. (In Russ.)
22. Filatova ES, Lila AM. Contribution of neurogenic mechanisms to the pathogenesis of chronic joint pain. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2021; 15(2):43-49. (In Russ.). doi: 10.14412/1996-7012-2021-2-43-49
23. Olyunin YuA. Chronic musculoskeletal pain. Leading symptom or comorbid pathology? Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2022;16(3):96-102. (In Russ.]. doi: 10.14412/1996-7012-2022-3-96-102
24. Melikova NA, Filatova EG, Lila AM. Fibromyalgia in rheumatoid arthritis: features of pain syndrome, impact on disease activity and quality of life of patients. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2022;16(1):32-37. (In Russ.). doi: 10.14412/1996-7012-2022-1-32-37
25. Mülkoglu C, Ayhan FF. The impact of coexisting fibromyalgia syndrome on disease activity in patients with psoriatic arthritis and rheumatoid arthritis: A cross-sectional study. Mod Rheumatol. 2021 Jul;31(4):827-833. doi: 10.1080/14397595.2020.1823069.
26. Gist AC, Guymer EK, Eades LE, et al. Fibromyalgia remains a significant burden in rheumatoid arthritis patients in Australia. Int J Rheum Dis. 2018 Mar;21(3):639-646. doi: 10.1111/1756-185X.13055.
27. Joharatnam N, McWilliams DF, Wilson D, et al. A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis. Arthritis Res Ther. 2015 Jan 20;17(1):11. doi: 10.1186/s13075-015-0525-5.
28. Das D, Choy E. Non-inflammatory pain in inflammatory arthritis. Rheumatology (Oxford). 2023 Jul 5;62(7):2360-2365. doi: 10.1093/rheumatology/keac671.
29. Tesher MS, Graham TB, Ting T, et al. Juvenile Fibromyalgia in Patients With Juvenile Idiopathic Arthritis: Utility of the Pain and Symptom Assessment Tool. Arthritis Care Res (Hoboken). 2022 Dec;74(12):2085-2090. doi: 10.1002/acr.24739.
30. Santimov AV. Psychosomatic aspects of chronic pain syndrome in juvenile idiopathic arthritis. Autoref. diss. cand. med. sci. Saint-Petersburg; 2020
31. Kaleda MI, Arefieva AN, Nikishina IP. Musculoskeletal symptoms in juvenile onset systemic lupus erythematosus. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2023;17(4):90-96. (In Russ.). doi: 10.14412/1996-7012-2023-4-90-96
32. Torrente-Segarra V, Salman Monte TC, Rua-Figueroa I, et al. Juvenile- and adult-onset systemic lupus erythematosus: a comparative study in a large cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER). Clin Exp Rheumatol. 2017 Nov-Dec;35(6):1047-1055.
33. Wolfe F, Clauw DJ, Fitzcharles MA, et al. Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia. J Rheumatol. 2011 Jun;38(6):1113-22. doi: 10.3899/jrheum.100594.
34. Corbitt K, Carlucci PM, Cohen B, et al. Clinical and Serologic Phenotyping and Damage Indices in Patients With Systemic Lupus Erythematosus With and Without Fibromyalgia. ACR Open Rheumatol. 2024 Apr;6(4): 172-178. doi: 10.1002/acr2.11641. Epub 2024 Jan 9.
35. Elefante E, Tani C, Stagnaro C, et al. Articular involvement, steroid treatment and fibromyalgia are the main determinants of patient-physician discordance in systemic lupus erythematosus. Arthritis Res Ther. 2020 Oct 14; 22(1):241. doi: 10.1186/s13075-020-02334-5.
36. Donnelly C, Cunningham N, Jones JT, et al. Fatigue and depression predict reduced health-related quality of life in childhood-onset lupus. Lupus. 2018 Jan;27(1):124-133. doi: 10.1177/0961203317716317.
37. Jones JT, Cunningham N, Kashikar-Zuck S, Brunner HI. Pain, Fatigue, and Psychological Impact on Health-Related Quality of Life in Childhood-Onset Lupus. Arthritis Care Res (Hoboken). 2016 Jan;68(1):73-80. doi: 10.1002/acr.22650.
38. Dubost JJ, Couderc M, Pereira B, et al. Concomitant fibromyalgia in primary Sjögren's syndrome in the French ASSESS cohort: comparison of the ACR 1990 and ACR 2016 criteria, FiRST questionnaire and physician's opinion. Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):140-145. URL: https://pubmed.ncbi.nlm.nih.gov/34919043/.
39. Choi BY, Oh HJ, Lee YJ, Song YW. Prevalence and clinical impact of fibromyalgia in patients with primary Sjögren's syndrome. Clin Exp Rheumatol. 2016 Mar-Apr;34 (2 Suppl 96):S9-13.
40. Haliloglu S, Carlioglu A, Akdeniz D, et al. Fibromyalgia in patients with other rheumatic diseases: prevalence and relationship with disease activity. Rheumatol Int. 2014 Sep;34(9): 1275-80. doi: 10.1007/s00296-014-2972-8.
41. Ayar K, Metin Ökmen B, Altan L, et al. The Frequency of Fibromyalgia and its Relationship With Disease Activity in Female Patients With Behcet's Disease: A Cross Sectional Study. Arch Rheumatol. 2020 Jan 8;35(3): 401-408. doi: 10.46497/ArchRheumatol.2020.7729.
42. El-Rabbat MS, Mahmoud NK, Gheita TA. Clinical significance of fibromyalgia syndrome in different rheumatic diseases: Relation to disease activity and quality of life. Reumatol Clin (Engl Ed). 2018 Sep-Oct;14(5):285-9. doi: 10.1016/j.reuma.2017.02.008.
43. Perrot S, Peixoto M, Dieude P, et al. Patient phenotypes in fibromyalgia comorbid with systemic sclerosis or rheumatoid arthritis: influence of diagnostic and screening tests. Screening with the FiRST questionnaire, diagnosis with the ACR 1990 and revised ACR 2010 criteria. Clin Exp Rheumatol. 2017 May-Jun;35 Suppl 105(3):35-42.
44. Costa SP, Lage LV, da Mota LM, de Carvalho JF. Fibromyalgia in primary antiphospholipid (Hughes) syndrome. Lupus. 2011 Oct; 20(11):1182-6. doi: 10.1177/0961203311411962.
45. Thune P. The coexistence of amyopathic dermatomyositis and fibromyalgia. Acta Derm Venereol. 2000 Nov-Dec;80(6):453-4. URL: https://pubmed.ncbi.nlm.nih.gov/11243647/.
46. Sambataro G, Orlandi M, Fagone E, et al. Myositis-Specific and Myositis-Associated Antibodies in Fibromyalgia Patients: A Prospective Study. Biomedicines. 2023 Feb 22;11(3):658. doi: 10.3390/biomedicines11030658.
47. Alibaz-Oner F, Can M, lhan B, et al. Presence of fibromyalgia in patients with Takayasu's arteritis. Intern Med. 2013;52(24):2739-42. doi: 10.2169/internalmedicine.52.0848.
48. Hajj-Ali RA, Wilke WS, Calabrese LH, et al. Pilot study to assess the frequency of fibromyalgia, depression, and sleep disorders in patients with granulomatosis with polyangiitis (Wegener's). Arthritis Care Res (Hoboken). 2011 Jun;63(6):827-33. doi: 10.1002/acr.20442.
49. Van Eeden C, Mohazab N, Redmond D, et al. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia: PR3-versus MPO-ANCA-associated vasculitis, an exploratory cross-sectional study. Lancet Reg Health Am. 2023 Feb 27;20:100460. doi: 10.1016/j.lana.2023.100460.
50. Alayli G, Durmus D, Ozkaya O, et al. Frequency of juvenile fibromyalgia syndrome in children with familial Mediterranean fever: effects on depression and quality of life. Clin Exp Rheumatol. 2011 Nov-Dec;29(6 Suppl 69):S127-32.
51. Karakus N, Yigit S, Inanir A, et al. Association between sequence variations of the Mediterranean fever gene and fibromyalgia syndrome in a cohort of Turkish patients. Clin Chim Acta. 2012 Dec 24;414:36-40. doi: 10.1016/j.cca.2012.07.019.
52. Ovrom EA, Mostert KA, Khakhkhar S, et al. A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia. Biomedicines. 2023 Apr 7;11(4):1119. doi: 10.3390/biomedicines11041119.
53. Polli A, Hendrix J, Ickmans K, et al. Genetic and epigenetic regulation of Catechol-O-methyltransferase in relation to inflammation in chronic fatigue syndrome and Fibromyalgia. J Transl Med. 2022 Oct 25;20(1):487. doi: 10.1186/s12967-022-03662-7.
54. Santimov AV, Grechanyi SV, Novik GA. The twin method in the study of the influence of genetic and family factors on the comorbidity of chronic musculoskeletal pain, anxiety and depression in children and adolescents. Voprosy psikhicheskogo zdorov'ya detei i podrostkov. 2022;22(4):52-63. (In Russ.)
55. Santimov AV, Grechanyi SV, Novik GA. Mental disorders in children with rheumatic diseases. Nauchno-Prakticheskaya Revmatologia. 2024;62(1):109-117. (In Russ.)
Review
For citations:
Santimov AV, Grechanyi SV, Novik GA. Secondary fibromyalgia in children with immune-inflammatory rheumatic diseases. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2024;18(3):99-106. https://doi.org/10.14412/1996-7012-2024-3-99-106