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Современная ревматология

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Применение нимесулида в ревматологии

https://doi.org/10.14412/1996-7012-2008-492

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Аннотация

Представлены данные об основных механизмах действия нимесулида - нестероидного противовоспалительного препарата, обладающего противовоспалительной, анальгетической и антипиретической активностью при широком спектре болезненных состояний. Показана скорость наступления эффекта после приема различных форм нимесулида при подагрическом артрите, а также рассмотрены аспекты его безопасности и переносимости при ревматических заболеваниях.

Литература

1. <div><p>The paper gives data on the basic mechanisms of action of nimesulide, a nonsteroidal anti-inflammatory drug that has anti-inflammatory, analgesic, and antipyretic activities in a broad spectrum of morbid states. It shows the rate of effect occurrence after administration of different nimesulide formulations in gouty arthritis and considers the aspects of its safety and tolerability in rheumatic diseases.</p><p>Ward A., Brogden R.N. Nimesulide. A preliminary review of its pharmacological properties and therapeutic efficacy in inflammation and pain states. Drugs 1988; 36 (6): 732-53.</p><p>Dreiser R.L. Nimesulidi in the treatment of osteoarthritis of the hip: a dose-finding study. Helsinn, Internal Report, 1991.</p><p>Bourgeois P.I., Dreiser R.L., Lequesne M.G. et al. Multi-centre double-blind study to define the most favourable dose of Nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis. Eur J Rheum Inflam 1994; 14: 39-50. 4.</p><p>Herrera J.A., Gonzalez M. Comparative evaluation of the effectiveness and tolerability of nimesulide versus rofecoxib taken once a day in the treatment of patients with knee osteoarthritis. Am J Ther 2003 Nov-Dec; 10(6): 468-72.</p><p>Famaey J.P., Vanderkerckhove K., Geczy J. et al. A large, open-label trial of nimesulide in patients with osteoarticular conditions treated in a general practice setting. Curr Ther Res 1998; 59: 467-82.</p><p>Omolulu B., Alonge T.O., Ogunlade S.O. et al. Double blind clinical trial comparing the safety and efficacy of nimesulide (100 mg) and diclofenac in osteoarthrosis of the hip and knee joints. West Afr J Med 2005 Apr-Jun; 24(2): 128-33.</p><p>Bianchi M., Broggini M., Balzarini P. et al. Effects of nimesulide on pain and synovial fluid concentrations of substance P, inter-leukin-6 and interleukin-8 in patients with knee osteoarthritis: comparison with celecox-ib. Int J Clin Pract 2007 Aug; 61(8): 1270-7.</p><p>Sarzi-Puttini P., Santadrea S., Boccassini L. et al. The role of NSAID in psoriatic arthritis: evidence from a controlled study with nimesulide. Clin Exp Rheumatol 2001; 19 (1 suppl. 22): 17-20.</p><p>Балабанова Р.М. Эффективность и переносимость нимесила - растворимой формы нимесулида - при ревматоидном артрите (предварительные результаты). Науч-практич ревматол 2002; 1: 60-1.</p><p>Кудаева Ф.М., Елисеев М.С., Барскова В.Г. и др. Сравнение скорости наступления анальгетического и противовоспалительного эффектов различных форм нимесулида и диклофенака натрия при подагрическом артрите. Тер арх 2007; 5: 35-4.</p><p>Bree F., Nguyen P., Urien S. et al. Nimesulid binding to components within blood. Drugs 1993; 46(1): 83-90.</p><p>Bernareggi A. Clinical pharmacokinetics of nimesulide. Clin Pharm 1998; 35(4): 247-74.</p><p>Bunczak-Reeh M.A., Hargreaves K.M. Effect of inflammation on the delivery of drugs to dental pulp. J Endodontics 1998; 24: 822-4.</p><p>Pulkkinen M.O. Nimesulide in dysmen- orrhoea. Drugs 1993; 46(1): 129-33.</p><p>Warner T.D., Guiliano F., Vojnovic I. et al. Nonsteroid drug selectivities for cyclooxygenase-1 rather than cyclooxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 1999; 96: 7563-8.</p><p>Barnett J., Chow J., Ives D. et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1994; 1209: 130-9.</p><p>Famaey J-P. In vitro and in vivo pharmacological evidence of selective cyclo-oxygenase-2 inhibition by nimesulide: an overview. Inflamm Res 1997; 46: 437-46.</p><p>Tavares I.A., Bishai P.M., Bennet A. Activity of nimesulide on constitutive and inducible cyclo-oxygenases. Arzneim- Forsch/Drug Res 1995; 45: 1093-6.</p><p>Shah A.A., Murray F.E., Fitzgerald D.J. The in vivo assessment of nimesulide cyclooxygenase-2 selectivity. Rheumatology 1999; 38(1): 19-23.</p><p>Cryer B., Feldman M. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med 1998; 104: 413-21.</p><p>Marbet G.A., Yasikoff Strub M.L., Macciocchi A. et al. The effect of nimesulide versus placebo on hemostasis in healthy volunteers. Eur J Clin Pharmacol 1998; 54: 383-7.</p><p>Di Battista J.A., Fahmi H., He Y. et al. Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts. Clin Exp Rheumatol 2001; 19 (1 suppl. 22): 3-5.</p><p>Ferreira S.H. The role of interleukins and nitric oxide in the mediation of inflammatory pain and its control by peripheral analgesics. Drugs 1993; 46(1): 1-9.</p><p>Pelletier J.P., Mineau F., Fernandes J.C. et al. Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts. Clin Exp Rheumatol 1997; 15: 393-8.</p><p>Ottonello L., Dapino P., Pastorino G. et al. Inhibition of the neutrophil oxidative response induced by the oral administration of nimesulide in normal volunteers. J Clin Lab Immunol 1992; 37: 91-6.</p><p>Capecchi P.L., Ceccatelli L., Beermann U. et al. Inhibition of neutrophil function in vitro by nimesulide. Preliminary evidence of an adenosine-mediated mechanism. Arzneim-Forsch/Drug Res 1993; 43: 992-6.</p><p>Barracchini A., Franceschini N., Amicosante G. et al. Can non-steroidal anti-inflammatory drugs act as metalloproteinase modulators? An in vitro study of inhibition of collagenase activity. J Pharm Pharmacol 1998; 50: 1417-23.</p><p>Hentrotin Y.E., Labasse A.H., Simonis P.E. et al. Effects of nimesulide and sodium diclofenac on interleukin-6, interleukin-8, proteoglycans and prostaglandin E2 production by human articular chondrocytes in vitro. Clin Exp Rheumatol 1999; 17: 151-60.</p><p>Sharma S., Rastogi S., Gupta V. et al. Comparative efficacy and safety of nimesulide versus piroxicam in octeoarthritis with special reference to chondroprotection. Am J Therap 1999; 6: 191-7.</p><p>Huskisson E.C., Macciocchi A., Rahlfs V.W. et al. Nimesulide versus diclifenac in the treatment of osteoarthritis of the hip or knee: an active controlled equivalence study. Curr Ther Res 1999; 60: 253-65.</p><p>Brune K., Craf P. Non-steroidal anti-inflammatory drugs: influence of extra-cellular pH on biodistribution and pharmacological effects. Biochem pharmacol 1978; 27: 525-30.</p><p>Rainfsord K.D., Schweitzer A., Brune K. Autoradiographic and biochemical observations on the distribution of non-steroidal anti-inflammatory drugs. Arch Int pharmacodyn Therap 1991; 250: 180-94.</p><p>Bjarnason I., Thjodleifsson B. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs: the effect of nimesulide compared with naproxen on the human gastrointestinal tract. Rheumatology 1999; 38 (suppl. 1): 24-32.</p><p>Helin-Salmivaara A., Virtanen A., Veslainen R. et al. NSAID use and the risk of hospitalization for first myocardial infarction in the general population: a national case-control study from Finland. Eur Heart 2006; 27: 1657-63.</p><p>Барскова В.Г., Насонова ВА., Цапина Т.Н. и др. Эффективность и безопасность применения нимесила при подагрическом артрите. Клин мед 2004; 82 (12): 49-54.</p><p>Каратеев А.Е. Нестероидные противовоспалительные препараты в современной клинической практике: «за» больше, чем «против». Современная ревматология 2008; 1: 70-8.</p><p>Каратеев А.Е., Насонова В.А. НПВП-ассоциированная гепатопатия: проблема нимесулида. Науч-практич ревматол 2004; 1: 34-7.</p><p>Boelsterli U. Nimesulide and hepatic adverse affects: roles of reactive metabolites and host factors. Int J Clin Pract 2002; suppl. 128: 30-6.</p><p>Traversa G., Bianchi C., Da Cas R. et al. Cohort study of hepatotoxity associated with nimesulide and other non-steroidal anti- inflammatory drugs. BMJ 2003; 327: 18-22.</p><p>European Medicines Evaluation Agency, Committee for Proprietary Medicinal Products. Nimesulide containing medicinal products. CPMP/1724/04. &lt;http://www.emea.eu.int&gt;</p><p>Rainsford K.D. Relationship of nimesulide safety to its pharmacokinetics: assessment of adverse reactions. Rheumatology 1999; 38(1): 4-10.</p><p>Bennett A. The importance of COX-2 inhibition for aspirin-induced asthma. Thorax 2000; 2: 54-6.</p></div><br />


Для цитирования:


Il'ina A.E., Барскова В.Г., Кудаева Ф.М., Ilyina A.E., Барскова В.Г., Kudayeva F.M. Применение нимесулида в ревматологии. Современная ревматология. 2008;2(3):63-66. https://doi.org/10.14412/1996-7012-2008-492

For citation:


Il'ina A.E., Barskova V.G., Kudaeva F.M., Ilyina A.E., Barskova V.G., Kudayeva F.M. Use of nimesulide in rheumatology. Modern Rheumatology Journal. 2008;2(3):63-66. (In Russ.) https://doi.org/10.14412/1996-7012-2008-492

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)